Clinical trials: Cholesterol; Metabolic Disorder
Body Weight Changes, Physical Activity
Empowering Immigrant Women for Active and Healthy Lifestyle
The study will include overweight and obese otherwise healthy women, recruited from two main borough in Oslo with the highest population of Somali origin.
- Conditions
- Body Weight Changes, Physical Activity, Blood Glucose, Cholesterol, Elevated
- Trial name
- NCT04578067
- Testing
- Lifestyle intervention
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Hypercholesterolemia, Atherosclerosis
Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)
The purpose of this study is to obtain data of the coadministration of ezetimibe and rosuvastatin to support the concomitant use of these two drugs in patients requiring additional cholesterol-lowering management.
- Trial name
- NCT00651144
- Testing
- Ezetimibe + Rosuvastatin, Rosuvastatin, Ezetimibe
- Volunteers
- 40 people
- Sponsor
- Organon and Co
Type 2 Diabetes, Inflammation
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease.
- Conditions
- Type 2 Diabetes, Inflammation, Insulin Sensitivity/Resistance, Fatty Acids, Omega-3
- Trial name
- NCT04485871
- Testing
- Omega-3 fatty acids
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Cliniques de Montreal
Dyslipidemia
ABT-335 (Choline Fenofibrate) Reverse Cholesterol Transport (RCT) Study
The objectives of the study are: 1. To evaluate the effect of ABT-335 (choline fenofibrate) on several parameters of RCT (reverse cholesterol transport) in men and post-menopausal women diagnosed with dyslipidemia (i.e., low…
- Trial name
- NCT00673881
- Testing
- choline fenofibrate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radiant Research
Hypercholesterolemia
Coadministration of Ezetimibe and Atorvastatin in Patients With Primary Hypercholesterolemia (P05456)
Evaluate the safety of the long-term (1 year) coadministration of ezetimibe and atorvastatin in participants with hypercholesterolemia who have not reached low density lipoprotein (LDL)-cholesterol target with…
- Trial name
- NCT00654095
- Testing
- Ezetimibe, atorvastatin
- Volunteers
- 146 people
- Sponsor
- Organon and Co
Lipid Metabolism Disorders
Cholesterol Effects of Kori-tofu Proteins
The study is a randomized, cross-over, double-blind, controlled trial in which participants with mildly elevated levels of cholesterol will receive two 4-week interventions (e.g.
- Trial name
- CHOKO (NCT04896619)
- Testing
- Kori tofu bread, Whey protein bread
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Wageningen University and Research
Hypercholesterolemia, Overweight and Obesity
Metabolic Effect of an Innovative Chitosan Formulation
Chitosan is a natural polysaccharide of β-1,4-linked glucosamine residues deriving from chitin, a dietary fiber primarily obtained from fungal cell walls and the exoskeletons of various crustaceans (e.g.
- Trial name
- CHITOCHOL (NCT05188430)
- Testing
- Medical Device (Kaptufat®)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Atherosclerosis, Cardiovascular Diseases
Cholesterol Reduction in Seniors Program (CRISP)
To conduct a pilot study to determine whether lowering elevated serum cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors reduced mortality due to the sequelae of atherosclerotic…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00000477
- Testing
- lovastatin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lipoprotein Disorder
A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events
The main purpose of this study is to evaluate the efficacy and safety of LY3473329 in adult participants with elevated Lp(a) at high risk for cardiovascular events.
- Trial name
- KRAKEN (NCT05563246)
- Testing
- LY3473329
- Where
- 42 sites in United States, Australia and 6 more
- Volunteers
- 233 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Diseases, Hyperlipidemias
Supplementation of Oil Palm Phenolics to Healthy Participants
Our previous study has found that oil palm phenolics (OPP) supplementation at 9 grams per day is safe for consumption. An interesting observation was reported where the consumption of OPP showed significantly lower total and LDL…
- Conditions
- Cardiovascular Diseases, Hyperlipidemias, Hypercholesterolemia
- Trial name
- SPIRAL (NCT04164446)
- Testing
- Oil Palm Phenolics
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Cardiovascular Diseases
Effect of Apple and Apple Pomace on Inflammation and Cholesterol Metabolism in Healthy Overweight
The investigators will assess the protective and antiinflammatory effects of processed fruit and fruit fibre in overweight subjects with signs of metabolic syndrome.
- Trial name
- NCT01141803
- Testing
- Apples, Apple pomace
- Where
- Denmark
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypercholesterolemia
Effects of Black Tea Intake on Serum Lipids
A diet-controlled clinical trial which attempts to provide estimates of the effect of black tea consumption on serum lipids under tightly controlled conditions, including a controlled diet.
- Trial name
- NCT01882283
- Testing
- Tea Treatment Group
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mucopolysaccharidosis I, Mucopolysaccharidosis VI
Human Placental-Derived Stem Cell Transplantation
The purpose of this clinical trial is to investigate the safety of human placental-derived stem cells (HPDSC) given in conjunction with umbilical cord blood (UCB) stem cells in patients with various malignant or nonmalignant…
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis VI, Adrenoleukodystrophy, Niemann-Pick Disease
- Trial name
- HPDSC (NCT01586455)
- Testing
- Human Placental Derived Stem Cell
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- New York Medical College
Cholesterol Ester Storage Disease(CESD), Lysosomal Acid Lipase Deficiency
Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency
This was the first clinical study of SBC-102 (sebelipase alfa) for the treatment of Lysosomal Acid Lipase (LAL) Deficiency. It was an open-label dose escalation study in adult participants with liver dysfunction due to LAL…
- Conditions
- Cholesterol Ester Storage Disease(CESD), Lysosomal Acid Lipase Deficiency, LAL-Deficiency
- Trial name
- NCT01307098
- Testing
- Sebelipase alfa 0.35 mg/kg, Sebelipase alfa 1 mg/kg, Sebelipase alfa 3 mg/kg
- Where
- 7 sites in United States, Czechia and 2 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Type 2 Diabetes
A Phase 2b Study of DIO-902 or DIO-902 Placebo in Addition to Metformin and Atorvastatin or Atorvastatin Placebo for Type 2 Diabetes
DiObex Inc. is developing an experimental drug (DIO-902) that is made up of part of the ketoconazole molecule for the treatment of elevated blood glucose associated with type 2 diabetes mellitus.
- Trial name
- NCT00494663
- Testing
- DIO-902
- Where
- 24 sites in United States, Australia and 1 more
- Volunteers
- 200 people
- Sponsor
- DiObex
Hypercholesterolemia, Familial
Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy
The aim of this study is to assess the safety and efficacy of varying doses of ISIS 301012 as add-on therapy in subjects with Homozygous Familial Hypercholesterolemia
- Trial name
- NCT00280995
- Testing
- ISIS 301012
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 12 people
- Sponsor
- Kastle Therapeutics, LLC
Sitosterolemia
The Effect of Dietary Sitosterol on Blood Sugar and Cholesterol
This study will determine if dietary supplements of sitosterol (a plant cholesterol commonly found in vegetables) can modify blood sugar and cholesterol levels and reduce the stiffness of the blood vessels in people with an…
- Trial name
- NCT00531128
- Testing
- High/Low Sitosterol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight; Hyperlipidemia
Efficacy and Safety of Fermented Barley on Decrement of Body Fat in Obese Subjects
Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied.
- Trial name
- NCT01402128
- Testing
- Barley beta-glucan(3.0g)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Hyperlipidemias
Effects of Moderate Intensity Intermittent and Moderate Intensity Continuous Training on Hyperlipdemia
This project will be a Randomized control trial conducted to check the effects of moderate intensity intermittent training versus moderate intensity continuous training on indices of cardio-metabolic health in women with…
- Trial name
- NCT05078736
- Testing
- Moderate intensity intermittent training, Moderate intensity continuous training
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Cardiovascular Risk Factor, Cholesterol; Lipidosis
Meta-analysis of the Portfolio Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Portfolio diet, a dietary pattern that includes nuts, viscous fibre, plant protein, and plant sterols.
- Trial name
- NCT03534414
- Testing
- Portfolio Dietary Pattern, NCEP Based Diet
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
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