Clinical trials: Cholesterol; Metabolic Disorder
Cardiovascular Disease
"Hjerteloeftet" ("HeartLift"). Interaction For Preventing Cardiovascular Disease
Early interventions to promote physical activity, dietary lifestyle changes and optimal medication for cardiovascular risk factor reduction - 3 years follow-up. A randomized Clinical Trial.
- Trial name
- HeartLift (NCT01741428)
- Testing
- Intervention (INT1)
- Where
- Norway
- Volunteers
- 701 people
- Sponsor
- LHL Helse
Cholesterol, Elevated, Clinical Decision Support
Statin Reminders for Improving Prescribing in Primary Care
Statins reduce cardiovascular events and mortality, but only 30% of eligible primary care patients nationally are on statins. Clinical decision support (CDS) interventions in the electronic health record (EHR) can deliver…
- Conditions
- Cholesterol, Elevated, Clinical Decision Support, Education
- Trial name
- NCT06456658
- Testing
- Interruptive Reminder, Non-interruptive Reminder, No Reminder
- Where
- United States
- Volunteers
- 3,332 people
- Sponsor
- Vanderbilt University Medical Center
Non-alcoholic Fatty Liver Disease, Cholesterol Ester Storage Disease
Novel Association of Cholesterol Ester Storage Disease Due to Lysosomal Acid Lipase Deficiency and Non-Alcoholic Fatty Liver Disease: A Prospective Clinical Study
Non-alcoholic fatty liver disease (NAFLD) is a world-wide problem with a global prevalence estimated at 1.5 billion people. It is characterised by significant diversity and phenotypic heterogeneity.
- Trial name
- NCT01791452
- Where
- Israel
- Sponsor
- Assy Nimer
Hypertension, Diabetes
Creating Healthier Communities Through Meaningful Partnerships: A Model From the National African American Male Wellness Initiative - OSU Partnership
Primary Objective: Test feasibility and acceptability of a 24-week community-based lifestyle intervention to improve cardiovascular health among African American males.
- Conditions
- Hypertension, Diabetes, Sedentary Behavior, High Cholesterol
- Trial name
- NCT04787978
- Testing
- Physical Activity and Education Intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Ohio State University
Coronary Heart Disease, Cardiovascular Disease
Physiological Study of Human Cholesterol Metabolism and Excretion
The underlying hypothesis is that whole body cholesterol - including cholesterol present in tissues that cannot be measured by standard blood tests - is related to heart disease risk.
- Conditions
- Coronary Heart Disease, Cardiovascular Disease, Dyslipidemia, Disorder of Cholesterol Metabolism
- Trial name
- NCT01603758
- Testing
- Ezetimibe
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Richard E. Ostlund Jr., MD
Cardiovascular Disease
Cholesterol Metabolism in Heterozygous Phytosterolemia
The purpose of the study is to examine the effect of plant sterols on cholesterol absorption and synthesis in people with heterozygous phytosterolemia.
- Trial name
- NCT01102647
- Testing
- phytosterol ester
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type 2 Diabetes
Effects of Cranberry Extractive on the Lipid Profiles in Subjects With Type 2 Diabetes
Cranberry, containing flavonoids, is effective on improvement of lipid profiles in non-diabetic subjects. The Hypothesis of is to assess the effect of cranberry on lipid profiles in type 2 diabetic patients using oral…
- Trial name
- NCT00695526
- Testing
- cranberry
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Stress, Blood Sugar; High
Daily Blood Glucose Trends in Patients at Risk for Diabetes
The goal of this study is to learn about the relationship between blood sugar, diet, stress, and metabolic parameters including waist circumference, body mass index (BMI), cholesterol levels and blood pressure in patients at risk…
- Conditions
- Stress, Blood Sugar; High, Cholesterol, Elevated, Diet Habit
- Trial name
- NCT06000735
- Testing
- 7-Day Continuous Glucose Monitoring with Abbott Freestyle Libre 2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karol E. Watson, MD
Dyslipidemias
The Effect Of Low-Fat And Low-Cholesterol Dietary Intervention On LDL Sub-Groups In Turkısh Dyslipidemic Patients
The aim of this study is to compare LDL sub-group concentration before and after a diet with low-fat and low-cholesterol prescribed to dyslipidemic patients for 12 weeks.
- Trial name
- NCT04894318
- Testing
- Low-fat and low-cholesterol diet
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- TC Erciyes University
Cardiovascular Disease, Diabetes
Cholesterol, Hypertension and Glucose Education Study
The goal of this study is to improve cardiovascular disease (CVD) and cholesterol in African Americans adults with diabetes by addressing the modifiable risk factors of systolic blood pressure (SBP), glycosylated hemoglobin (Hb…
- Trial name
- CHANGE (NCT00815789)
- Testing
- Tailored cardiovascular risk management (Nurse-administered )
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- Duke University
Lateral Epicondylitis
Metabolic and Inflammatory Indices in Lateral Epicondylitis
This study aims to investigate whether metabolic and inflammatory indices differ between patients with chronic lateral epicondylitis (tennis elbow) and individuals without the condition.
- Trial name
- NCT07876778
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
HIV, Dyslipidemia
HIV Reverse Cholesterol Transport Study
Primary Objective: To examine changes in expression of genes [particularly ABCA1 and SREBP2] involved in reverse cholesterol transport (RCT) in monocytes from HIV-infected subjects starting antiretroviral therapy and the…
- Trial name
- HIV RCTS (NCT01670968)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College Dublin
Dyslipidemia, Obesity, Abdominal
Effects of Almond Intake on Atherogenic Lipoprotein Particles
Increased abdominal adiposity is a key feature of metabolic syndrome, which describes a cluster of cardiovascular disease (CVD) risk factors that also includes insulin resistance, high blood pressure and an atherogenic…
- Trial name
- NCT01792648
- Testing
- Standard reference diet, Almond supplemented diet, Low carbohydrate reference diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Hypercholesterolemia
A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.
This study is a phase IV, open-label, randomized study designed to evaluate the efficacy of Inclisiran vs. bempedoic acid (BPA) in 400 adult subjects (≥ 18 years) at very high and high risk for cardiovascular events as defined by…
- Trial name
- NCT06431763
- Testing
- Inclisiran sodium, BPA
- Where
- 55 sites in Germany
- Volunteers
- 402 people
- Sponsor
- Novartis Pharmaceuticals
Hypercholesterolemia
Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol
Primary Objective: To assess the effects of subcutaneous (SC) doses of alirocumab on the elimination (measured by Fractional Clearance Rate (FCR)) of apolipoprotein B (apoB) in low density lipoprotein (LDL) in adults with mildly…
- Trial name
- NCT01959971
- Testing
- alirocumab
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sanofi
Atherosclerotic Cardiovascular Disease
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).
- Trial name
- VICTORION-2P (NCT05030428)
- Testing
- Inclisiran sodium 300 mg
- Where
- 983 sites in United States, Argentina and 48 more
- Volunteers
- 17,004 people
- Sponsor
- Novartis Pharmaceuticals
Obesity, Hypercholesterolemia
Lentils as a Functional Food to Improve Glucose and Decrease Cardiovascular Risk
Compared to control foods, consumption of 3 cups of cooked lentils given weekly for 12 weeks will significantly improve glucose tolerance and lower LDL-cholesterol in individuals with high cholesterol and obesity.
- Trial name
- LEN-0-2012 (NCT01562171)
- Testing
- Cooked Lentils, Potato-Based Foods
- Where
- 2 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University of Manitoba
Metabolic Syndrome X
Flaxseed Intervention on Metabolic Syndrome
The purpose of this study is to determine whether daily supplement of 30 grams flaxseed is effective in the treatment of metabolic syndrome (MetS).
- Trial name
- FIMS (NCT00733772)
- Testing
- flaxseed, Health lifestyle counseling
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Chinese Academy of Sciences
Dyslipidemias
Study to Evaluate the Safety of the Fixed-dose Combination Rosuvastatin/Ezetimibe for Patients With Dyslipidaemia
Retrospective, analytical, longitudinal, multicenter study to evaluate the safety of the fixed-dose combination of rosuvastatin / ezetimibe as treatment for patients with dyslipidemia in routine medical practice.
- Trial name
- TREZETE (NCT04862962)
- Testing
- Rosuvastatin 10 or 20mg /Ezetimibe 10 mg Fixed Dose
- Where
- Mexico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
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