Clinical trials: Cholesterol; Metabolic Disorder
Cardiovascular Disease, Hyperlipidemia
The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors.
- Trial name
- NCT01235832
- Testing
- Avocado Diet, Lower-Fat Diet, Moderate Fat Diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Penn State University
Dyslipidemia
An Observational Study Investigating the Change in Blood Cholesterol With Mevalotin® Tablet Administration in Korean Menopausal Women Aged 50 Years or More Who Require Treatment of Dyslipidemia
This study will investigate the efficacy and safety based on the observation of the blood cholesterol change with Mevalotin® Tablet administration in Korean menopausal women aged 50 years or more who require treatment of…
- Trial name
- NCT05120895
- Testing
- Mevalotin
- Where
- 58 sites in South Korea
- Volunteers
- 3,060 people
- Sponsor
- Daiichi Sankyo
Psoriasis, Metabolic Syndrome
Effect of Vitamin D Supplementation on Metabolic Parameters of Patients With Psoriasis
The purpose of this study is to determine whether supplementation with oral vitamin D (cholecalciferol) improves metabolic parameters in patients with moderate to severe psoriasis.
- Conditions
- Psoriasis, Metabolic Syndrome, Vitamin D Deficiency
- Trial name
- NCT02271971
- Testing
- Vitamin D3
- Where
- Chile
- Volunteers
- 39 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiovascular Diseases, Heart Diseases
HDL-C in Cardiac Syndrome X
High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver[10].
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Ischaemia, Unstable Angina
- Trial name
- HIRICS-X (NCT02095964)
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Hypercholesterolemia, Hypertension
Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol
Cells in the lining of blood vessels produce various substances that cause the vessels to dilate (relax) and constrict (tighten), thereby regulating blood flow.
- Trial name
- NCT00006071
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome X, Prediabetic State
Education, Counseling, and Drug Therapy to Reduce Symptoms of Metabolic Syndrome
This study will determine the effects of a supplement in reducing symptoms of metabolic syndrome, a collection of symptoms that increase the risk for developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Prediabetic State, Insulin Resistance, Obesity
- Trial name
- NCT00129792
- Testing
- Dietary supplement for weight loss, Education and counseling for weight loss
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Oregon Health and Science University
Hypercholesterolemia
Effect of Combination Therapy With Two Drugs (Colesevelam and Ezetimibe) in Patients With High Cholesterol
Assess the efficacy of WelChol® plus Zetia® in treating patients with high cholesterol
- Trial name
- NCT00185107
- Testing
- Colesevelam Hydrochloride, Ezetimibe, Simvastatin
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Daiichi Sankyo
Atherosclerosis, LDL-hypercholesterolemia
Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis
Elevated LDL-cholesterol is a major risk factor for heart disease. In patients with heart disease LDL-cholesterol should be lowered to levels below 70 mg/dl to prevent progression of disease.
- Trial name
- MICA (NCT01598948)
- Testing
- mipomersen
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Hypercholesterolemia, Breast Cancer
Plant Sterol INtervention for Cancer Prevention (PINC)
Several types of human cells convert cholesterol into other molecules, including oxysterols. Oxysterols can promote breast cancer growth and help tumours to spread.
- Conditions
- Hypercholesterolemia, Breast Cancer, Obesity
- Trial name
- PINC (NCT04147767)
- Testing
- Cholesterol Reducing Strawberry Yogurt Drink (Tesco Ltd), Low Fat Strawberry Yogurt Drinks (Morrisons Ltd)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Dyslipidemias
Effect of Niacin on Transport of HDL and Relationship to Atherogenic Lipoproteins and Lipolysis
This study looks at whether niacin improves reverse cholesterol transport (RCT) in healthy volunteers. 3H-Cholesterol will be used to measure RCT by analyzing changes in the tracer activity in total plasma, lipoproteins, red…
- Trial name
- ENTHRALL (NCT01250990)
- Testing
- Niacin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mixed Hyperlipoproteinemia
Efficacy Study of Daily Pro-Omega LDL for Low-Density Lipoprotein Cholesterol and Triglyceride Reduction
Pro-Omega LDL reduces low-density lipoprotein cholesterol and triglycerides in subjects with mixed hyperlipoproteinemia.
- Trial name
- PrOteCT (NCT02069106)
- Testing
- Pro-Omega LDL
- Sponsor
- Nordic Pharma, USA
Cholesterol; Metabolic Disorder, Lipoproteinemia
Kinetic Study of Lp(a) and PCSK9 in Humans
The aim is to study the relationship between lipoprotein(a) [Lp(a)] and PCSK9 (Proprotein Convertase Subtilisin/Kexin type 9) in humans with a kinetic study of lipoproteins in patients with dramatic increase of Lp(a) and controls.
- Trial name
- HuLaUP (NCT04247048)
- Testing
- infusion of tracer [5,5,5-2H3] -L-leucine
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Nantes University Hospital
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and Triglycerides
The primary purpose of this study is to test the effect and safety of three different doses of ABT-143 compared to simvastatin in subjects with elevated levels of low density lipoprotein cholesterol ("bad cholesterol") and…
- Trial name
- NCT00812955
- Testing
- ABT-143, simvastatin
- Where
- 129 sites in United States
- Volunteers
- 474 people
- Sponsor
- AstraZeneca
Dyslipidemia, Menopause
Dose-response Study of Carduus Marianus in Centesimal Scale for Dyslipidemia in Climacteric Overweighed or Obese Women.
Metabolic disorders including hypercholesterolemia and hypertriglyceridemia are present in climacteric women. Carduus marianus is a homeopathic medicine that traditionally has been used for hepatic diseases.
- Conditions
- Dyslipidemia, Menopause, Obesity
- Trial name
- NCT02775448
- Testing
- Carduus marianus 6cH, Carduus marianus 12cH, Carduus marianus 30cH
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Hospital Nacional Homeopático, Mexico
Type 2 Diabetes Mellitus, Cardiovascular Disease
Effects of Achieving Very Low LDL-Cholesterol After Treatment With Statins on Steroidogenesis and Cognition
We aimed to compare the effect of achieving an LDL-cholesterol <70 vs an LDL-cholesterol <100 mg/dL with simvastatin or atorvastatin on adrenal and testicular steroidogenesis, and cognition in diabetic patients.
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, LDL Cholesterol, Cognition
- Trial name
- NCT00522158
- Testing
- simvastatin, atorvastatin
- Sponsor
- Baskent University
Hyperlipidemia, Hypercholesterolemia
Cholesterol and Pharmacogenetic Study
The overall objective of the CAP study was to determine genetic influences on efficacy of simvastatin treatment with regard to LDL cholesterol reduction and changes in other markers of cardiovascular disease risk.
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Coronary Heart Disease, Cardiovascular Disease
- Trial name
- CAP (NCT00451828)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Hypercholesterolemia, Medication Adherence
Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults
The purpose of this study is to pilot test a behavioral medication adherence (MA) intervention compared to control condition in older adults with low adherence to medication for hypercholesterolemia.
- Trial name
- NCT01227330
- Testing
- Medication adherence intervention, Attention-control
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Missouri-Columbia
Hurler's Syndrome, Maroteaux-Lamy Syndrome
Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism
The primary objective of this clinical trial is to evaluate the ability to achieve and sustain donor engraftment in patients with lysosomal and peroxisomal inborn errors of metabolism undergoing hematopoietic stem cell…
- Conditions
- Hurler's Syndrome, Maroteaux-Lamy Syndrome, Sly Syndrome, Alpha Mannosidosis
- Trial name
- NCT00668564
- Testing
- Stem Cell Transplantation, Cyclophosphamide, Campath-1H
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Familial Hypercholesterolemia
Impact of LDL-cholesterol Lowering on Platelet Activation
The primary goal is to assess the impact of Evolocumab therapy on platelet function of familial hypercholesterolemia (FH) patients in a randomized, double blind study.
- Trial name
- NCT03331666
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Columbia University
Obesity, Hypertension
The Effects of Metformin on Blood Vessel Structure and Function
The purpose of this study is to evaluate whether the drug Metformin has beneficial effects on the blood vessels of individuals with the Metabolic Syndrome (MeS).
- Conditions
- Obesity, Hypertension, Hypercholesterolemia, Hyperglycemia
- Trial name
- NCT00105066
- Testing
- Metformin
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Institute on Aging (NIA)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.