Clinical trials: Choline Nutrition
Genomic and Metabolomic Variations, Preterm Birth
Effects of Genomic and Metabolomic Variations of Choline on Risk of Preterm Birth and Clinical Outcomes in Preterms
The incidence of preterm birth increases annually. Premature delivery has become the leading cause of neonatal illness and death.
- Conditions
- Genomic and Metabolomic Variations, Preterm Birth, Total Parenteral Nutrition
- Trial name
- NCT02841813
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Prader-Willi Syndrome
Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome
This is a single-center, open-label, single-arm study with a double-blind, placebo-controlled, randomized withdrawal extension. Patients are initiated on a DCCR dose of about 1.5 mg/kg (maximum starting dose of 145 mg) and are…
- Trial name
- NCT02034071
- Testing
- DCCR
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Essentialis, Inc.
Prader-Willi Syndrome
A 5 Treatment Period Pharmacokinetic Study Evaluating Dose Proportionality and Food Effects of Diazoxide Choline Controlled-Release Tablet (DCCR)
Open label, parallel-group, single site, 5 treatment-period study with 4 dose levels of DCCR, 1 of which is administered both with and without food.
- Trial name
- NCT02893618
- Testing
- Diazoxide choline controlled-release tablet
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Essentialis, Inc.
Severe Acute Malnutrition in Childhood
Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza
This is a randomized clinical trial to learn whether ready-to-use therapeutic foods enriched with choline and docosahexaenoic acid (DHA) together with psychosocial stimulating activities work well to improve child development in…
- Trial name
- BRIGHTSAM (NCT06781918)
- Testing
- Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- National Institute for Medical Research, Tanzania
Liver Diseases
Total Parenteral Nutrition-Associated Liver Disease
This is a study to determine whether choline, when added to total parenteral nutrition (TPN), can help prevent the development of hepatic steatosis, a liver disease, in patients on TPN.
- Trial name
- NCT00031135
- Testing
- Choline Chloride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Northwestern University
Hyperhomocysteinemia
The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers
A methyl-group acceptor such as guanidinoacetic acid (GAA) could induce hyperhomocysteinemia with the effects of GAA expected to be dose-dependent.
- Trial name
- NCT01371357
- Testing
- TEST 1, TEST 2, TEST 3
- Where
- Serbia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Nutrition
Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease
The purpose of this study is to see if intestinal bacteria plays a role in choline metabolism (a form of choline monitored in this study is called phosphatidylcholine, also known as lecithin).
- Trial name
- Glory (NCT01519310)
- Testing
- Antibiotic (metronidazole and ciprofloxacin)/probiotic
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Brain Development, Choline Nutrition
Pilot Study of Prenatal Choline Supplementation
A double-blind, randomized, placebo-controlled trial (RCT; NCT04395196) of prenatal choline supplementation is ongoing (1) to assess the effectiveness of maternal choline supplementation during pregnancy to mitigate effects of…
- Trial name
- NCT07699393
- Testing
- Choline bitartrate
- Where
- South Africa
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Nutrition During Pregnancy
PREnatal Choline and Infant Outcomes Study
Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development.
- Trial name
- PRECIOUS (NCT07525193)
- Testing
- Choline nutrition education (CNE)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Off-spring Cancer Risk
Parental One-carbon Folate and Choline Nutrition Modulates Risk of Off-spring Cancer Development: Human Cohort Study
Parental one-carbon nutrient intake (folic acid and choline) and the genetic polymorphisms of one-carbon metabolic enzyme were interact with regulating embryonic one-carbon metabolic environment, affect fetal DNA and RNA…
- Trial name
- NCT02266641
- Testing
- nutrition counseling, multivitamin supplement
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obesity and Obesity-related Medical Conditions
Effect of Betaine and Choline on Metabolic Health
The purpose of this research is to determine whether extra betaine and choline influence metabolic health in adults with overweight and obesity.
- Trial name
- NCT06758856
- Testing
- Trimethylglycine, Eggs, Cellulose
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Prader-Willi Syndrome
Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome
The purpose of this is study is to evaluate the long-term safety of DCCR (diazoxide choline) extended-release tablets) in patients with Prader-Willi syndrome.
- Trial name
- NCT05701774
- Testing
- DCCR
- Where
- 22 sites in United States, United Kingdom
- Volunteers
- 77 people
- Sponsor
- Soleno Therapeutics, Inc.