Clinical trials: Chorioretinopathy
Central Serous Chorioretinopathy
Navigated Microsecond Laser for Chronic Central Serous Chorioretinopathy: MICROPULSE
MICROPULSE study aims to evaluate the efficacy of navigated microsecond laser (nMSL) for chronic central serous chorioretinopathy (CSCR).
- Trial name
- MICROPULSE (NCT05679180)
- Testing
- micropulse laser
- Sponsor
- University Hospital, Bordeaux
Choroidal Neovascularization, Mineralocorticoid Excess
Biomarkers and Choroidal Neovascularization
The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
- Trial name
- BioNéoRet (NCT04439708)
- Testing
- Blood and aqueous humor biomarker of treatment response
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Birdshot Chorioretinopathy, Cystoid Macular Edema
Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a
Birdshot Retine choroidopathy (BRC) is a sight threatening posterior uveitis. The long term visual outcome has recently be studied showing a legal blindness to 14% at 5 years.
- Conditions
- Birdshot Chorioretinopathy, Cystoid Macular Edema, Transient Partial Visual Loss
- Trial name
- BIRDFERON (NCT00508040)
- Testing
- interferon alpha 2a, prednisone
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Central Serous Chorioretinopathy
Short-Term Oral Mifepristone for Central Serous Chorioretinopathy
The goal of the study is to assess the efficacy and safety of mifepristone 300 or 900-mg once-daily dosing by mouth for 4 weeks in patients with central serous chorioretinopathy.
- Trial name
- STOMP-CSC (NCT02354170)
- Testing
- Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Roger Goldberg, M.D., MBA
Central Serous Chorioretinopathy
The Changes of Retinal Capillaries After Half-dose PDT Measured by OCTA in Eyes With CSC
To determine changes in retinal and choroidal capillaries with optical coherence tomographic angiography (OCTA) after half-dose photodynamic therapy (hd-PDT) in eyes with central serous chorioretinopathy (CSC).
- Trial name
- NCT03692169
- Testing
- Half-dose photodynamic therapy
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Jin Chen-jin
Central Serous Chorioretinopathy
Methotrexate for Central Serous Chorioretinopathy Treatment Trial
Central serous chorioretinopathy (CSC) is a disease of unknown origin however multiple reports have indicated correlation of appearance of CSC with exposure to exogenous or elevated levels of endogenous corticosteroid.
- Trial name
- MTX4CSC (NCT01633983)
- Testing
- Methotrexate, Delayed treatment
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Edward Averbukh
Central Serous Chorioretinopathy
Study of Photodynamic Therapy (PDT) in Patients With Central Serous Chorioretinopathy (CSC)
The purpose of this study is to determine the safety and efficacy of PDT at 30% verteporfin dose in the treatment of CSC.
- Trial name
- NCT01574430
- Testing
- PDT
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Peking University People's Hospital
Central Serous Chorioretinopathy
Brinzolamide for the Treatment of Chronic Central Serous Chorioretinopathy
Examine the efficacy of brinzolamide for the treatment of central serous chorioretinopathy
- Trial name
- NCT03542006
- Testing
- Brinzolamide Ophthalmic
- Where
- 2 sites in Argentina, Israel
- Volunteers
- 35 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Retinal Disease
Evaluation and Treatment of Patients With Retinal Disease
This study offers evaluation and treatment for patients with certain diseases of the retina (the layer of light-sensitive tissue that lines the inside of the eyeball).
- Trial name
- NCT00005784
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Eye Institute (NEI)
Central Serous Chorioretinopathy
The Safety & Efficacy of Intravitreal Aflibercept Injection in Patients With Persistent Central Serous Chorioretinopathy
A preliminary study to determine the safety and efficacy of intravitreal aflibercept injection in patients with persistent central serous chorioretinopathy.
- Trial name
- CONTAIN (NCT01710332)
- Testing
- Intravitreal Aflibercept Injection
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Wills Eye
Chronic Central Serous Chorioretinopathy
Pseudo-PDT in Central Serous Chorioretinopathy
Acute central serous chorioretinopathy (CSC) is a common disorder in middle-aged patients, characterized by serous retinal detachment in the macular region.
- Trial name
- NCT02799992
- Testing
- 689 nm Laser Treatment of the Macula, Half Dose Photodynamic Therapy
- Volunteers
- 22 people
- Sponsor
- Università degli Studi di Brescia
Central Serous Chorioretinopathy
Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy
Patients with central serous chorioretinopathy (CSC) will be monitored with laser speckle flow graphy (LSFG), swept source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA).
- Trial name
- NCT05589974
- Testing
- Verteporfin
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Chronic Central Serous Chorioretinopathy
Treatment of Chronic Central Serous Chorioretinopathy With Open-Label Anecortave Acetate
Investigation to evaluate Anecortave Acetate in the treatment of chronic central serous chorioretinopathy
- Trial name
- CSC-AA (NCT00489840)
- Testing
- Anecortave Acetate Sterile suspension 15 mg, Anecortave Acetate
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Chronic Central Serous Chorioretinopathy
Microperimetric Evaluation After Half-dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
A half-dose photodynamic therapy, a relative new treatment, has been widely performed to treat central serous chorioretinopathy.
- Trial name
- NCT01434095
- Testing
- half-dose photodynamic therapy
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Surugadai Nihon University Hospital
Retinal Disease
Pilot Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is a retinal disorder characterized by an accumulation of serous fluid under the retina. Although acute CSC tends to spontaneously resolve on its own with minimal sequelae, chronic CSC tends…
- Trial name
- NCT00837252
- Testing
- Finasteride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Central Serous Chorioretinopathy
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) has been known since it was first described by Von Graefe and termed "idiopathic detachment of the macula" in 1866, is a well-characterized disorder leading to serous neurosensory elevation…
- Trial name
- NCT00418431
- Testing
- Intravitreal injection of Bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Age- Related Macular Degeneration, Diabetic Retinopathy
A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics Analysis
This project systematically investigates the role of the intraocular microbiome in various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and cataracts.
- Conditions
- Age- Related Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT07897513
- Testing
- Not applicable- observational study
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Central Serous Chorioretinopathy
Efficacy and Safety of Intravitreal Aflibercept Injection for Subacute Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is a self-limiting disease that usually associated with good visual prognosis. In some cases, however, CSC may persist and result in permanent retinal or retinal pigment epithelium (RPE)…
- Trial name
- NCT01971190
- Testing
- Intravitreal Aflibercept injection, Half-fluence photodynamic therapy
- Where
- 6 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Asan Medical Center
Central Serous Chorioretinopathy
Eplerenone For the Treatment of Chronic Central Serous Chorioretinopathy
The aim of the study is to determine the efficacy and safety in treating patients with chronic central serous chorioretinopathy with the drug eplerenone.
- Trial name
- NCT02153125
- Testing
- Eplerenone
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chorioretinopathy, Obstructive Sleep Apnea
Association Between CRSA and OSA
This goal of this study is to know the association between the central serous chorioretinopathy and the obstructive sleep apnea.
- Trial name
- CRSA (NCT04634786)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Poitiers University Hospital