Clinical trials: Chromosomal Aneuploidies
Aneuploidy, Down Syndrome
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women?
Informed decision-making regarding aneuploidy screening has been reported to be low. Poor knowledge and the lack of deliberation have been cited as reasons for uninformed choices, highlighting the need for adequate pre-test…
- Conditions
- Aneuploidy, Down Syndrome, Pregnancy Early
- Trial name
- EVA (NCT05492981)
- Testing
- Enhanced (intervention) education
- Where
- Singapore
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Aneuploidy
A Pilot Study for Implementation of First Trimester Screening of Aneuploidies in Campania Region
The study aims to compare two different protocols for first trimester screening of aneuploidies, one based on nuchal translucency and NIPT and another one based on the integration between combined test and NIPT, in order to…
- Trial name
- PISTA (NCT05798858)
- Testing
- NIPT
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Federico II University
Chromosomal Aneuploidies, Single Gene Desease
Genomic DNA in Human Blastocoele Fluid
The objective will focus on the characterization of DNA fragments present in Blastocoele fluid, and the evaluation of these fragments as potential target for Preimplantation Genetic Diagnosis.
- Trial name
- NCT01780415
- Testing
- blastocoele aspiration
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cervesi Hospital, Cattolica, Italy
Infertility
Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization
Preimplantation embryo aneuploidy is a major source of adverse outcomes in human reproduction since it leads to implantation failure, early pregnancy loss or severe chromosomal diseases.
- Trial name
- Devit (NCT04758819)
- Testing
- Comprehensive chromosomal Testing of Trophectoderm biopsies of Blastocysts (CTTEB)
- Where
- 10 sites in France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aneuploidy, Genetic Disease
Effect of Video Education on Patients' Knowledge and Attitudes of Privacy in Prenatal Genetics
The investigators propose a randomized controlled trial to assess baseline maternal knowledge of and attitudes toward commercial prenatal genetic testing laboratories' genetic privacy practices, and to determine whether a brief…
- Conditions
- Aneuploidy, Genetic Disease, Pregnancy Related
- Trial name
- NCT04420858
- Testing
- Enhanced (experimental) education, Standard (control) education.
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Any Single Gene Disorder (Cystic Fibrosis, Tay-Sachs)
Concurrent Single Gene and 24 Chromosome Aneuploidy Preimplantation Genetic Diagnosis (PGD)
Gene Security Network has developed a novel technology called Parental SupportTM (PS) which is used for Preimplantation Genetic Screening/Diagnosis (PGS/D) during in vitro fertilization (IVF).
- Trial name
- IVF008 (NCT01023048)
- Testing
- preimplantation diagnosis
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Male Infertility
Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile Men
In men presenting sperm alterations, the selection of genetically undamaged spermatozoa need to be improved in order to increase the success of assisted reproduction treatments.
- Trial name
- VATES (NCT02006446)
- Testing
- Sperm Samples
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen