Clinical trials: Chromosomal Aneuploidies, open to volunteers
Infertility (IVF Patients)
Pilot Study of Discarded Blastocysts
The goal of this observational study is to determine multiomics patterns related to global embryo quality to help overcome the limitations of conventional embryo quality assessment.
- Trial name
- DECODE (NCT07429097)
- Testing
- Multiomics analysis
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Igenomix
Down Syndrome, Fetal Aneuploidy
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
- Trial name
- NCT01429389
- Where
- 14 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Sequenom, Inc.
Pregnant Individuals, Aneuploidy
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment
The goal of the ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) study is to compare the concordance of results of a novel non-invasive circulating fetal cell (CFC) assay to the results of…
- Conditions
- Pregnant Individuals, Aneuploidy, Down Syndrome (Trisomy 21), 22q11.2 Deletion Syndrome
- Trial name
- ADVANCE (NCT07643896)
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- BillionToOne Inc.
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
Klinefelter Syndrome, Trisomy X
The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
This study is designed to research the natural history of neurodevelopment, health and early hormonal function in infants with XXY/Klinefelter syndrome, XYY, XXX and other sex chromosome variations in an effort to identify early…
- Conditions
- Klinefelter Syndrome, Trisomy X, XYY Syndrome, XXXY and XXXXY Syndrome
- Trial name
- NCT03396562
- Testing
- Assessments of Development and Growth
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Aneuploidy, Mosaicism
Pregnancy and Developmental Outcomes After Transfer of Reportedly Aneuploid or Mosaic Embryos
To determine how often embryos reported to be abnormal by preimplantation genetic testing result in liveborn infants. To evaluate whether the pregnancies that result from these embryos are higher risk for complications and…
- Conditions
- Aneuploidy, Mosaicism, Pregnancy Outcome
- Trial name
- TAME (NCT04109846)
- Testing
- Non-euploid embryo transfer, Euploid Transfer
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stanford University
Aneuploidy
Danish Prognostic Research on Embryonic Diagnostics Involving Chromosomal Testing.
The study aim is to evaluate whether testing embryos for chromosomal abnormalities (known as aneuploidy) can aid in embryo selection.
- Trial name
- DanPREDICT (NCT06915311)
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Christian Liebst Frisk Toft
Sex Chromosome Disorders
A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies
We will examine is Social Management Training, a 10-session group-based psychosocial intervention will improve the primary outcome mental health, and secondary outcomes executive functions and autism symptoms, in a multiple…
- Trial name
- TRICXY-SMT (NCT07718997)
- Testing
- Social Management Training
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Sex Chromosome Aneuploidy
Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY)
GALAXY is a registry research study that plans to learn more about individuals with X\&Y variations (also called sex chromosome aneuploidies) through collecting information from medical records.This includes genetic tests…
- Trial name
- GALAXY (NCT06373861)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Genetic Counseling
Prenatal Genetics Chatbot Trial: Prenatal GENEie
During pregnancy, all pregnant people are offered tests to look for genetic conditions in the baby. However, there isn't a standard way of giving this information to patients.
- Trial name
- NCT07077707
- Testing
- Prenatal GENEie Chatbot, In-person genetic counseling
- Where
- United States
- Volunteers
- 1,470 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Infertility, Mosaicism
Non-Euploid Embryo Transfer (NEET) Registry
The NEET Registry is a registry to track and study the outcomes of non-euploid embryo transfers (NEET) in The Prelude Network
- Conditions
- Infertility, Mosaicism, Aneuploidy
- Trial name
- NCT07036536
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Genetic Disease
Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing
Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF.
- Conditions
- Infertility, Genetic Disease, Chromosomal Rearrangement, Aneuploidy
- Trial name
- NCT06023472
- Testing
- microfluidic chip, density gradient centrifugation
- Where
- China
- Volunteers
- 318 people
- Sponsor
- Professor Ernest Hung-Yu Ng
Complex Aneuploidy, Chaotic Aneuploidy
Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos
This study aims to evaluate the reproductive potential of embryos classified as "complex aneuploid" (involving three or more abnormal chromosomes) or "chaotic" (six or more abnormal chromosomes) through preimplantation genetic…
- Trial name
- ESCALATE (NCT07227116)
- Where
- 12 sites in United States, Chile
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility
PICSI Impact on Euploidy in Assisted Reproduction
Hyaluronic acid (HA) is a major component of the cumulus complex surrounding oocytes. Intracytoplasmic sperm injection (ICSI) involves injection of a selected sperm into the oocyte.
- Trial name
- NCT06602687
- Testing
- PICSI
- Where
- Ireland
- Volunteers
- 142 people
- Sponsor
- Merrion Fertility Clinic