Clinical trials: Chronic Airway Disease
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts
This is an investigator-initiated, prospective, single-centre, randomised, phase II, open-label study, testing the superiority of ticagrelor, as compared to clopidogrel, in modulating on-P2Y12 treatment platelet reactivity…
- Trial name
- NATHAN-NEVER (NCT02519608)
- Testing
- Aspirin 100 mg, Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University Hospital of Ferrara
Pulmonary Disease, Chronic Obstructive
A Phase 1 (Ph1), Single Dose (SD), GSK961081 Absorption, Distribution, Metabolism, and Excretion (ADME) Study in Healthy Subjects
Batefenterol (GSK961081) is a bifunctional bronchodilator that is being developed for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02663089
- Testing
- [14C]-GSK961081 solution for IV infusion, [14C]-GSK961081 oral solution, GSK961081 dry powder for inhalation
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Chronic Obstructive Pulmonary Disease
Dietary Intervention Increasing Omega-3 Intake
This Dietary Intervention is being done to evaluate the feasibility of a food voucher program and dietary counseling to increase consumption of healthy fatty acids (omega-3) in individuals with Chronic Obstructive Pulmonary…
- Trial name
- NCT03806868
- Testing
- voucher for ordering foods (ONLY omega-3 rich foods), voucher for ordering foods in general (any type of foods)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
COPD
Physiotherapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is projected to be the fifth leading burden of disease worldwide by the year 2020. An acute exacerbation of COPD (AECOPD) is defined as an acute event characterized by a worsening of…
- Trial name
- NCT02515318
- Testing
- Physiotherapy program, Medical standard treatment
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Pulmonary Rehabilitation
Effect of Combined IMT and CPAP in Pulmonary Rehabilitation for COPD
Inspiratory muscle training(IMT) was one of the widely used pulmonary rehabilitation method in COPD patients.However, when the respiratory muscles are fatigue without sufficient rest, IMT may increase muscle fatigue and aggravate…
- Trial name
- NCT03919513
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Respiratory Diseases
Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.
- Trial name
- CHRONOBIO (NCT06366113)
- Testing
- Pulmonary rehabilitation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Michaël RACODON
Pulmonary Disease, Chronic Obstructive (COPD)
E-nose Utility in the Diagnosis of Bacterial Infection in COPD
Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection
- Trial name
- NCT01976117
- Testing
- enose
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Obstructive Pulmonary Disease
Safety of Ramelteon in Subjects With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine if ramelteon has respiratory depressant effects in subjects with moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT00316992
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- Takeda
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COPD
Placebo Controlled Evaluation of Sedation and Physiological Response to Intranasal Dexmedetomidine in Severe COPD
A variety of medications have been used to treat the anxiety, discomfort, and fear associated with continuous and sudden episodic breathlessness in patients with advanced respiratory disease.
- Trial name
- NCT02773797
- Testing
- IN-DEX 1.0 mcg/kg, intranasal saline, IN-DEX 1.5 mcg/kg, intranasal saline
- Where
- United States
- Sponsor
- Dayton VA Medical Center
Chronic Obstructive Pulmonary Disease
Community-based Management of Chronic Obstructive Pulmonary Disease in Nepal
Chronic Obstructive Pulmonary Disease (COPD) is the fourth most important cause of death worldwide and is one of the commonest non-communicable diseases (NCDs) in Nepal.
- Trial name
- COBIN-P (NCT03797768)
- Testing
- Behavioural-FCHV Visit
- Where
- Denmark
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease
Health Literacy in People With Chronic Obstructive Pulmonary Disease
Health literacy refers to personal and relational factors affecting a person's ability to acquire, understand and use information about health and health services.
- Trial name
- NCT03216603
- Testing
- Health literacy intervention group
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Lovisenberg Diakonale Hospital
COPD
Dyspnea Threshold During 6 Minutes Walk Test
In view of the multiple limitations and restrictions relative to CPET (technical, time, physical…), determination of individualized training threshold from this evaluation is today not possible for a lot of patients.
- Trial name
- SD6 (NCT02082925)
- Testing
- Patient has to get up his hand when he defined his dyspnea threshold during 6MWT
- Where
- France
- Volunteers
- 82 people
- Sponsor
- 5 Santé
Heart Failure, Pulmonary Disease, Chronic Obstructive
Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
The aim of the present study is: 1. To investigate pulmonary function abnormalities (restriction, obstruction, diffusion impairment, mixed pulmonary defects) in patients with chronic heart failure (CHF) and to determine which of…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Inflammation
- Trial name
- NCT01429376
- Testing
- Pulmonary function tests, Blood tests, Questionnaires
- Where
- 2 sites in Netherlands
- Volunteers
- 234 people
- Sponsor
- Rijnstate Hospital
Chronic Obstructive Pulmonary Disease
Effect of Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Tiotropium: The HELIOS Study (BY217/M2-128)
The aim of the study is to compare the efficacy of roflumilast to placebo on pulmonary function and symptomatic parameters in patients with chronic obstructive pulmonary disease (COPD) during concomitant administration of…
- Trial name
- HELIOS (NCT00424268)
- Testing
- Roflumilast
- Where
- 103 sites in Austria, France and 5 more
- Volunteers
- 743 people
- Sponsor
- AstraZeneca
COPD, Kinesiophobia Due to Dyspnea
Clinical Variables and Dyspnea and Fear of Movement in Chronic Obstructive Pulmonary Patients
Patients diagnosed with COPD who applied to the Pulmonary Diseases Department of Kırıkkale Yüksek İhtisas Hospital will be included in the study.
- Trial name
- NCT06442059
- Testing
- Kinesiophobia Level Due to Dyspnea
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Kırıkkale University
Pulmonary Disease, Chronic Obstructive
Morphine for Treatment of Dyspnea in Patients With COPD
Dyspnea is the most reported symptom of patients with advanced Chronic Obstructive Pulmonary Disease (COPD) and is undertreated.
- Trial name
- MORDYC (NCT02429050)
- Testing
- sustained release morphine
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Empyhsema, Pulmonary Disease, Chronic Obstructive
The Spiration Valve System for the Treatment of Severe Emphysema
This is a multicenter, prospective, randomized, controlled study being conducted in China to evaluate improvement of lung function after treatment with the Spiration Valve System as compared to medical management in the control…
- Trial name
- REACH (NCT01989182)
- Testing
- Spiration Valve System, Medical Management
- Where
- 12 sites in China
- Volunteers
- 107 people
- Sponsor
- Olympus Corporation of the Americas
ASTHMA
AVAD: Asthma With Small Airways Dysfunction
The aim of the study is to describe asthma phenotype with small airways dysfunction, in a multiparametric manner, with clinical, biological, morphological and genetic elements compared with asthma with proximal airways…
- Trial name
- AVAD (NCT02593279)
- Testing
- asthma with proximal airways obstruction phenotype profile description with clinical, biological, morphologic and genetic elements., asthma with small airways dysfunction phenotype profile description with clinical, biological, morphologic and genetic elements.
- Where
- 4 sites in France
- Volunteers
- 11 people
- Sponsor
- Hospices Civils de Lyon
Chronic Obstructive Pulmonary Disease (COPD), Nasal High Flow Oxygen Therapy
Efficacy of HFNC Combined With Sequential NIV in Patients With COPD Complicated With Type II Respiratory Failure
The goal of this clinical trial is to investigate the efficacy of high-flow nasal cannula oxygen therapy (HFNC) combined with sequential non-invasive ventilation (NIV) in patients with chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Nasal High Flow Oxygen Therapy, Noninvasive Ventilation, Respiratory Failure
- Trial name
- NCT06992479
- Testing
- high-flow nasal cannula oxygen therapy (HFNC) combined with sequential non-invasive ventilation (NIV), NIV routine treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing YouAn Hospital
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