Clinical trials: Chronic Aphasia
Aphasia, Cerebrovascular Stroke
Transcranial Magnetic Stimulation to Improve Speech in Aphasia
The purpose of this study is to examine whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with aphasia. Aphasia patients can have problems with speech production.
- Trial name
- NCT00608582
- Testing
- Transcranial Magnetic Stimulation, Repetitive
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Boston University
Aphasia, Acquired, Chronic Stroke
VR and Script Training of PWA
The goal of this intervention study is to investigate the effects of immersive virtual reality in rehabilitation of language and communication of individuals with post-stroke aphasia. The main research questions are: 1.
- Trial name
- NCT05667480
- Testing
- VR-based script training, Conventional script training
- Where
- Hong Kong
- Volunteers
- 26 people
- Sponsor
- The Hong Kong Polytechnic University
Aphasia
Effects of Transcranial Direct Current Stimulation in Post-stroke Aphasia
This study aims to determine whether transcranial direct current stimulation (tDCS) paired with speech-language therapy is more beneficial than speech-language therapy alone in acute and chronic post-stroke aphasia.
- Trial name
- NCT02622945
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Sponsor
- Johns Hopkins University
Aphasia
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia
Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group.
- Trial name
- NCT03651700
- Testing
- Active TMS, CILT
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- H. Branch Coslett
Aphasia, Stroke
Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia
Post-stroke aphasia (PSA), the partial or total loss of the ability to produce and/or understand language associated with stroke, is a highly prevalent and disabling disorder that negatively impacts the personal, social and…
- Trial name
- NCT04134416
- Testing
- Donepezil, Intensive-Language Action Therapy, Transcranial direct current stimulation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Malaga
Stroke, Aphasia
Donepezil in Chronic Poststroke Aphasia: a Randomized Controlled Trial
Aphasia (impairment of language function due to brain damage)may be treated with speech-language therapy and drugs. Several drugs have been studied but with limited success.
- Trial name
- NCT00196690
- Testing
- Donepezil
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Gabinete Berthier y Martínez
Stroke, Aphasia Following Cerebral Infarction
Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors
The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke.
- Conditions
- Stroke, Aphasia Following Cerebral Infarction, Hemiparesis After Stroke
- Trial name
- CARAT (NCT07000019)
- Testing
- CARAT: combined aphasia and robot-assisted arm therapy, Robot-assisted arm therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York Medical College
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Aphasia
TMS in Aphasia Recovery
Stroke often causes substantial problems in speaking or understanding speech. Treatments for these problems are currently very limited.
- Trial name
- NCT04777214
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Stroke-induced Aphasia
Overcoming Learned Non-Use in Chronic Aphasia
In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech.
- Trial name
- NCT02012374
- Testing
- Intensive Language Action Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Brain Injury, Vascular, Aphasia
Treatment of Grammatical Time Marking in Post-Stroke Aphasia
The study aims to assess an individual or self-administered computer therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs…
- Conditions
- Brain Injury, Vascular, Aphasia, Stroke
- Trial name
- NCT05656638
- Testing
- Speech and language therapy
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Neuchatel
Aphasia, Stroke
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity…
- Trial name
- METALEX (NCT06930131)
- Testing
- Semantic rehabilitation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Aphasia, Acquired
Effects of rTMS on Brain Activation in Aphasia
This study will investigate the use of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation method, to improve word-finding abilities in Veterans and non-Veterans with chronic language problems…
- Trial name
- NCT03292471
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Aphasia
Combining Language Therapy With rTMS in Aphasia
With the present RCT, the investigators aimed at finding an optimal protocol for the neurorehabilitation of chronic post-stroke aphasia by combining two promising methods, ILAT (Intensive language action therapy) and 1-Hz rTMS to…
- Trial name
- ILAT+rTMS (NCT03629665)
- Testing
- Intensive Language-Action Therapy (ILAT), Repetitive navigated Transcranial Magnetic Stimulation during naming training
- Volunteers
- 17 people
- Sponsor
- Paula Heikkinen
Aphasia, Acquired, Chronic Stroke
VR and Scrip Training of PWA, Randomized Controlled Trial
The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes.
- Trial name
- VRSTPWA (NCT06722092)
- Testing
- VR-based script training, Conventional script training
- Volunteers
- 105 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Aphasia
Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.
62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions.
- Trial name
- AphasiatDCS (NCT04432883)
- Testing
- Active Comparator: Experimental: Active cathodal tDCS + language training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of New Mexico
Aphasia, Apraxia of Speech
Changes in Neuroplasticity Following Intensive Rehabilitation of Aphasia and/or Apraxia of Speech
The present study aims to investigate the short- and long-term effects of two weeks of intensive speech-language pathology intervention with additional physiotherapy, on aphasia and apraxia of speech (AOS) and their neural…
- Conditions
- Aphasia, Apraxia of Speech, Dysarthria
- Trial name
- NCT04604444
- Testing
- Multimodal Intensive Rehabilitation of Aphasia and Apraxia of Speech
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Post Stroke Aphasia
Effect of High Frequency Transcranial Magnetic Stimulation on Recovery of Chronic Post-Stroke Aphasia
high frequency excitatory rTMS applied over the dominant hemisphere in chronic post stroke aphasic patients to help the restoration of function by the left hemisphere
- Trial name
- NCT04708197
- Testing
- rTMS (repetitive transcranial magnetic stimulation )
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Aphasia, Language
Phonological Treatment Paired With Intensive Speech Therapy Promotes Reading Recovery in Chronic Aphasia
Participants will receive either intensive phonology or semantic feature analysis treatment for 16 weeks to improve naming, reading, and writing in individuals with chronic post-stroke aphasia.
- Trial name
- NCT02799017
- Testing
- Intensive Phonology Treatment, Intensive SFA Treatment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Austin Speech Labs
Post-Stroke Chronic Aphasia, Anomia (Word-retrieval Impairment)
Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation
The purpose of this study is to determine if non-invasive electrical brain stimulation can enhance the out of intensive language therapy in chronic aphasia
- Trial name
- CATS (NCT01221779)
- Testing
- Intensive language therapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany