Clinical trials: Chronic Apical Periodontitis
Chronic Apical Periodontitis
A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates
This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.
- Trial name
- NCT04389346
- Testing
- Periapical surgery using autologous platelet aggregate, Periapical surgery without autologous platelet aggregate
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Root Canal Treatment, Intracanal Medicament
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments
Previously untreated, asymptomatic, single-rooted maxillary anterior teeth with periapical lesions <5 mm, no fractures, resorption, calcification, or recent antibiotic use will performed two-visit root canal treatment.
- Conditions
- Root Canal Treatment, Intracanal Medicament, Post Operative Pain, Apical Periodontitis
- Trial name
- NCT07210177
- Testing
- Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Periapical Periodontitis, Root Canal Infection
Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using different methods of irrigation activation.
- Trial name
- NCT03990584
- Testing
- three irrigation activation methods, conventional needle irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Apical Periodontitis
Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide
The goal of this clinical trial is to evaluate the effect of different intracanal medicaments-conventional calcium hydroxide (CH) and nano-sized calcium hydroxide (NCH)-on the intensity of postoperative pain following root canal…
- Trial name
- NCT07057336
- Testing
- Conventional Calcium Hydroxide (CH), Nanocalcium Hydroxide (NCH)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cukurova University
Periapical Periodontitis
Adrenomedullin Upregulation in Apical Periodontitis
The aim of the present study was to investigate the relationship between Apical periodontitis (AP) severity and inflammatory markers (IL-12, TNF-alpha), and Mid-Regional Pro Adrenomedullin (MR-proADM) in patients with AP.
- Trial name
- NCT05297747
- Testing
- Apical periodontitis, Chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Apical Periodontitis
Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection.
- Trial name
- NCT07892690
- Testing
- Cyperus articulatus
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Post Operative Pain
Postoperative Pain After Using Different Single-File Glide Path Systems
This study aimed to evaluate postoperative pain intensity after glide-path preparation with the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.Maxillary and…
- Trial name
- NCT05955742
- Testing
- Control, ProGlider, WaveOne Gold Glider
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Chronic Apical Periodontitis, Dental Implantation
Topical Melatonin for Immediate Implants in Chronically Infected Extraction Sockets
The purpose of this study is to evaluate the effect of topical 2% melatonin gel on implant stability and osseointegration of immediate implants placed in chronically infected extraction sockets.
- Conditions
- Chronic Apical Periodontitis, Dental Implantation, Infected Extraction Socket
- Trial name
- NCT07829393
- Testing
- Topical Melatonin, Control
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Implant Failure Nos, Periapical Granuloma
Periapical Lesions and Immediate Implants
The aim of this case-control study is to evaluate the success and survival rates of dental implants immediately placed into extraction sites in the presence of periapical pathology.
- Conditions
- Dental Implant Failure Nos, Periapical Granuloma, Osseointegration Failure of Dental Implant
- Trial name
- NCT06521203
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Chronic Apical Periodontitis of Pulpal Origin
Longitudinal Endodontic Study of Apical Preparation Size
This protocol is for a clinical trial evaluating the clinical success of root canal therapy performed on teeth with chronic apical periodontitis of pulpal origin with either large or small apical root canal preparation techniques.
- Trial name
- NCT00223379
- Testing
- Endodontic procedure with varied apical preparation size
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periapical Periodontitis, Chronic Periapical Periodontitis
Evaluation of Bone Healing After Obturation With Dia-Root Bio Sealer (Calcium Silicate-based Sealer CSBS) Using Three Obturation Techniques
The study aims to evaluate the efficiency of using a Calcium silicate-based sealer (CSBS) with different obturation techniques in treating root canals with apical periodontitis in single visit. Evaluating: 1.
- Conditions
- Periapical Periodontitis, Chronic Periapical Periodontitis, Periapical Abscess, Pulp Necrosis, Apical Periodontitis
- Trial name
- CSBS (NCT07684014)
- Testing
- Dia-Root Bio Sealer, Single cone (SC) Obturation technique, Warm Vertical compaction (WVC) technique
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Ain Shams University
Chronic Apical Periodontitis
Effects of Irrigation Activation Methods on Periapical Healing in Chronic Apical Periodontitis
This study aims to evaluate the effects of different irrigation activation methods on periapical healing in teeth with chronic apical periodontitis.
- Trial name
- NCT07850895
- Testing
- Sonic Irrigation Activation, Passive Ultrasonic Irrigation, Laser-Activated Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Recep Tayyip Erdogan University
Chronic Apical Periodontitis, Periapical Healing
MMP-2/3 and Periapical Healing Outcomes
This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical…
- Trial name
- NCT07529964
- Testing
- Nonsurgical Root Canal Treatment
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
Apical Periodontitis, Healhty
Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis
Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier…
- Trial name
- NCT07292363
- Testing
- Apical lesions cure
- Where
- 2 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Apical Periodontitis
Effect of Different Sealers and Activation Methods on Pain
In this study, the effects of different irrigation agitation methods and different root canal filling sealers on postoperative pain after root canal treatment will be evaluated.
- Trial name
- NCT06860191
- Testing
- Root Canal Sealants
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Periodontitis
Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
The purpose of the study is to investigate the effect of injectable platelet rich fibrin augmented with Vitamin C (ascorbic acid) in healing of chronic peri-apical lesion, by assessing it radiographically 2dimensionally and 3…
- Trial name
- NCT05585359
- Testing
- injectable platelet rich fibrin augmented with Vitamin C
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periapical Periodontitis, Alveolar Ridge Preservation
Rotary Versus Manual Degranulation in Alveolar Ridge Preservation
After a tooth is taken out, the empty socket needs to heal. Sometimes unhealthy soft tissue (called granulation tissue) is left behind and can slow down healing. This study compares two ways to clean the socket: 1.
- Trial name
- NCT07607314
- Testing
- Rotary Degranulation, Manual Curettage
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Chronic Apical Periodontitis
The Effect of Different Sodium Hypochlorite Concentrations and Activation Techniques on Postoperative Pain
The goal of this clinical trial was to evaluate the effect of different sodium hypochlorite (NaOCl) concentrations and irrigation activation techniques on the intensity of postoperative pain following single-visit root canal…
- Trial name
- NCT07033247
- Testing
- EDDY Sonic Activation System, Passive Ultrasonic Irrigation (PUI)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Cukurova University
Periapical Periodontitis
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
A total of 185 subjects were divided into three categories: AP group (n=85), CP group (n=50) and healthy control group (n=50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI) based on the…
- Trial name
- NCT06023901
- Testing
- Apical periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital