Clinical trials: Chronic Arthritis
Knee Osteoarthritis, Knee Arthritis
Pain Management After Adductor Canal Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the iPACK block with Adductor Canal Block on postoperative pain, functional recovery and NLR and PLR levels.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy, Knee Pain Chronic
- Trial name
- NCT06086483
- Testing
- Ropivacaine 0.2% Injectable Solution, 0.9%sodium chloride
- Where
- Poland
- Volunteers
- 361 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Knee
A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function
The purpose of this telemedicine 24-person open-label study is to evaluate the safety and usability of a proprietary wearable microcurrent electroceutical (a device that delivers micro-ampere electronic pulses) made by Healables…
- Trial name
- HEAL01WMCOA1 (NCT04938271)
- Testing
- HEAL-122 microcurrent electroceutical with e-textile sports knee sleeve
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Healables Ltd.
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Chronic Pain, Central Sensitisation
Brain MRI for Knee OA
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years.
- Conditions
- Chronic Pain, Central Sensitisation, Knee Osteoarthritis
- Trial name
- NCT05986513
- Testing
- Cold Pressor Gel Test
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Toronto Rehabilitation Institute
Osteoarthritis, Knee
Retrospective Study of the Results of Cooled Radiofrequency for Genicular Nerves Neurotomy in 40 Consecutive Patients With Osteoarthritis of the Knee and Painful Knee Arthroplasty
Analyze the results of cooled radiofrequency in patients with chronic knee pain after one year of follow- up.
- Trial name
- NCT03343808
- Testing
- cooled radiofrequency ablation of genicular nerves
- Volunteers
- 40 people
- Sponsor
- Hospital Son Espases
Rheumatoid Arthritis, Diabetic Neuropathy
Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training
CT-100 is a platform that provides interactive, software based therapeutic components that may be used as part of a multimodal treatment in supplementary or standalone prescription or nonprescription software-based digital…
- Conditions
- Rheumatoid Arthritis, Diabetic Neuropathy, Fibromyalgia, Irritable Bowel Syndrome
- Trial name
- NCT05573685
- Testing
- DiNaMo Study App
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Click Therapeutics, Inc.
Myocardial Infarction, Diet
Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort
Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures…
- Conditions
- Myocardial Infarction, Diet, Osteoarthritis
- Trial name
- NCT03350568
- Testing
- Total dietary NEAC assessed at baseline
- Where
- Sweden
- Volunteers
- 43,880 people
- Sponsor
- Karolinska Institutet
Rheumatoid Arthritis, Spondyloarthritis
Information and Acceptability of Biosimilars
Patients with rheumatoid arthritis or spondyloarthritis, currently treated or about to be started with anti-TNF original drug adalimumab or etanercept will be included and randomized to either " information leaflet only " or "…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- BIOSIMINFO (NCT04321291)
- Testing
- Generic information leaflet, Individual information by nurse on biosimilars
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Lumbar Osteoarthritis
Primary Osteoarthritis Lumbar Spine: Establishing Its Cause, Pathogenesis and Treatment.
The study was about a root cause of Primary Osteoarthritis Lumbar Spine producing disabilities in sitting, climbing and walking etc. In advance stage the person is bereft of his/her personal physical activities.
- Trial name
- NCT05693415
- Where
- 6 sites in India
- Volunteers
- 154 people
- Sponsor
- Knee Pain Clinic
Osteo Arthritis Knee, Knee Arthritis
Robotic-assisted Total Knee Arthroplasty vs. Conventional One
This study compares and evaluates differences in movement analysis, patient-reported outcome and radiological assesment between patients undergoing robotic-assisted total knee arthroplasty and conventional one.
- Conditions
- Osteo Arthritis Knee, Knee Arthritis, Knee Pain Chronic
- Trial name
- RATKA (NCT04611815)
- Testing
- Total knee arthroplasty, Computer tomography scan, biomechanical assesment
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Rheumatoid Arthritis, Renal Dysfunction
Subclinical Renal Dysfunction in Rheumatoid Arthritis
This comparative cross-sectional study aims to determine the prevalence of subclinical renal dysfunction in patients with rheumatoid arthritis and to evaluate its association with disease activity and inflammatory markers…
- Conditions
- Rheumatoid Arthritis, Renal Dysfunction, Chronic Kidney Diseases
- Trial name
- NCT07805109
- Volunteers
- 120 people
- Sponsor
- Assiut University
Ischemic Preconditioning
Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Knee Osteoarthritis
Introduction: Musculoskeletal disorders have affected approximately 1.3 billion people worldwide. Evidence shows that chronic diseases and musculoskeletal conditions often occur together, and among them it is estimated that more…
- Trial name
- NCT05059652
- Testing
- Ischemic Preconditioning
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Paulista University
Chronic Obstructive Pulmonary Disease (COPD), Smoking
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Idiopathic Pulmonary Fibrosis (IPF)
- Trial name
- NCT01776398
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Osteoarthritis Knee Pain
Revised Targets for Knee Radiofrequency Ablation
This research team is doing a study to learn more about a new way to treat long-term knee pain caused by joint damage. They are using a treatment called radiofrequency ablation (RFA).
- Trial name
- ReTaKRA (NCT06934421)
- Testing
- Ultrasound-Guided Genicular Nerve Radiofrequency Ablation
- Where
- 2 sites in Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
Spondylitis, Ankylosing
Extension in AS: Sustainability of Benefits, Safety and Tolerability
This 3-year extension study aims at making available the treatment with secukinumab in prefilled syringes (PFS) to patients with ankylosing spondylitis who took part in phase III study CAIN457F2305, defined as "core study", as…
- Trial name
- MEASURE 1 ext (NCT01863732)
- Testing
- Secukinumab
- Where
- 56 sites in United States, Belgium and 12 more
- Volunteers
- 274 people
- Sponsor
- Novartis Pharmaceuticals
Alcohol Abuse, Drug Abuse
Reducing Problematic Substance Use in Youth With Chronic Medical Conditions
The investigators goal is to pilot a substance use-related brief intervention (BI) for youth with chronic medical conditions, obtaining preliminary evidence of feasibility, acceptability and impacts of the approach for reducing…
- Trial name
- NCT01709201
- Testing
- Brief Intervention
- Where
- United States
- Sponsor
- Boston Children's Hospital
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee.
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain Chronic, Knee Osteoarthritis
- Trial name
- VV-KNEE (NCT07163312)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Knee Osteoarthritis (Knee OA), Chronic Pain
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
- Trial name
- PACE-UP (NCT07759336)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Benedict Alter
Diabetes Mellitus, Congestive Heart Failure
Homing in on Health: Study of a Home Delivered Chronic Disease Self Management Program
The purpose of the study is to determine the effectiveness of a home-delivered variant of the chronic disease self management program in improving health outcomes in patients with chronic conditions.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Arthritis, COPD
- Trial name
- NCT00263939
- Testing
- Homing in on Health
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Dry Eye Syndromes
Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms
- Trial name
- EXOIUMS (NCT06543667)
- Testing
- Limbal Stem Cell Derived Exosomes Eye Drop
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Iran University of Medical Sciences