Clinical trials: Chronic Arthritis
Arthritis, Arthralgia
Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab
The purpose of this study is to evaluate tolerability and effectiveness of conventional treatment for mild to moderate arthritic or arthralgic symptoms while subjects are being treated with efalizumab for psoriasis.
- Trial name
- NCT00510536
- Testing
- Acetaminophen, NSAID
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Probity Medical Research
Arthritis, Arthritis, Reactive
The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis
This study will evaluate patients with inflammatory forms of arthritis within the first year of onset. The study will attempt to clarify factors that may predict disease course such as evolution into rheumatoid arthritis (RA) or…
- Conditions
- Arthritis, Arthritis, Reactive, Arthritis, Rheumatoid, Reiter's Disease
- Trial name
- NCT00001375
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Gonarthrosis, Meniscus; Degeneration
Comparison of Ultrasound-Guided Perimeniscal Steroid and 5% Dextrose Injections in Knee Osteoarthritis
Introduction: The primary goal of treating knee osteoarthritis is to reduce pain and improve the patient's quality of life. Medial meniscal extrusion is a condition that is linked to pain and disability in knee osteoarthritis and…
- Conditions
- Gonarthrosis, Meniscus; Degeneration, Pain, Chronic
- Trial name
- NCT06308887
- Testing
- Triamcinolone Acetonide, Dextrose 5% in water
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kastamonu University
Knee Osteoarthritis, Chronic Knee Pain
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably.
- Trial name
- STAR-GNB (NCT07712419)
- Testing
- Ultrasound-Guided Genicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Hip Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Hip osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Hip Osteoarthritis
- Trial name
- NCT07347041
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA).
- Trial name
- NCT00348010
- Testing
- Tramadol HCl ER
- Volunteers
- 245 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Pain, Osteoarthritis, Hip
Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term joint safety and efficacy (pain relief) of the investigational study drug, tanezumab compared to non-steroidal anti inflammatory drugs (NSAIDs) in subjects with osteoarthritis…
- Conditions
- Chronic Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT02528188
- Testing
- NSAID, Tanezumab 2.5 mg, Tanezumab 5 mg
- Where
- 507 sites in United States, Australia and 16 more
- Volunteers
- 3,021 people
- Sponsor
- Pfizer
Non-radiographic Axial Spondyloarthritis
Efficacy and Safety Study of Secukinumab in Chinese Participants With Non-radiographic Axial Spondyloarthritis
The purpose of this study was to evaluate the efficacy, safety, and tolerability of secukinumab in Chinese patients with active non-radiographic axial spondyloarthritis (nr-axSpA).
- Trial name
- NCT04732117
- Testing
- Secukinumab
- Where
- 29 sites in China
- Volunteers
- 137 people
- Sponsor
- Novartis Pharmaceuticals
Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD)
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation…
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- DIETA-MICIREUM (NCT06862843)
- Testing
- Collecting questionnaires and biological samples
- Where
- 4 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Spinal Cord Injuries, Spina Bifida
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT05784285
- Testing
- Engagement in a 8-week community-based activity program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Knee Osteoarthritis, Knee Pain Chronic
Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty
This is a prospective, randomized, single-blinded, multi-center trial comparing Kinematic Alignment vs Mechanical Alignment in TKA patients using patient reported outcomes, clinical and functional performance tests and…
- Trial name
- KA vs MA (NCT05461638)
- Testing
- Mechanical Alignment and Unrestricted Kinematic Alignment using Medacta GMK Sphere with MyKnee Custom guides, Mechanical Alignment and Restricted Kinematic Alignment using Medacta GMK Sphere with custom cutting guides
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis
Effect of Genicular Nerve Block on Proprioception in Knee Osteoarthritis
The study was conducted to investigate the effect of genicular nerve block on pain, quality of life, and proprioception, which are already diminished due to the impact of osteoarthritis in individuals with knee osteoarthritis.
- Trial name
- NCT06744842
- Testing
- genicular nerve block, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Chronic Pain Management
The Beat Pain Better Trial
The Beat Pain Better study examines strategies to increase the reach of evidence-based interventions for persons with osteoarthritis (OA) in communities that experience disparities.
- Trial name
- NCT06932887
- Testing
- Text Messaging, Motivational Messaging, Physical Activity Counseling and Self-Directed Walk with Ease
- Where
- 3 sites in United States
- Volunteers
- 346 people
- Sponsor
- University of Utah
Knee Osteoarthritis
Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
This research is being done to evaluate whether combining medications that are FDA approved, but have not yet been approved for combination treatment, can be effective in reducing pain.
- Trial name
- NCT03098563
- Testing
- Blinded study medication
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Knee Osteoarthritis
Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis
This study is intended to prove the efficacy and safety of ultrasound-guided pulsed radiofrequency therapy on adductor canal nerves by patients with Knee osteoarthritis.
- Trial name
- NCT05962463
- Testing
- Canal adductor blockade, Canal adductor pulsed radio-frequency therapy
- Where
- Slovenia
- Volunteers
- 128 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Low Back Pain, Axial Spondyloarthritis
The IMPACT of a Referral Model for Axial Spondyloarthritis in Young Patients With Chronic Low Back Pain
Rationale: Axial spondyloarthritis (axSpA) is an inflammatory back pain disorder affecting up to 24% of young chronic low back pain (CLBP) patients.
- Trial name
- IMPACT (NCT01944163)
- Testing
- Applying a referral model
- Where
- Netherlands
- Volunteers
- 850 people
- Sponsor
- Maasstad Hospital
Hip Osteoarthritis, Chronic Pain
Ultrasound-Guided Hip Joint Cooled Radiofrequency Denervation
Hip osteoarthritis (HOA) is a common cause of pain and disability in aging population. Conservative treatment is based on lifestyle modifications, physical therapy, analgesic and anti-inflammatory medications and intra articular…
- Trial name
- NCT02546336
- Testing
- Ultrasound-Guided Cooled Radiofrequency Hip Denervation
- Where
- Canada
- Sponsor
- Women's College Hospital
Ulcer
Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450216
- Testing
- Ibuprofen/famotidine, Ibuprofen
- Volunteers
- 906 people
- Sponsor
- Amgen
Post Herpetic Neuralgia, Pain
A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.
This study is a 3-part, Double-blind, Randomized, Placebo-controlled, Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamic properties of iN1011-N17 after Oral Administration in Healthy…
- Conditions
- Post Herpetic Neuralgia, Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT06218784
- Testing
- iN1011-N17 HCl Suspension (Part 1), iN1011-N17 HCl Capsule (Part 1), iN1011-N17 HCl Capsule (Part 2)
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.