Clinical trials: Chronic Arthritis
Arthritis of the Knee
Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis
This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid…
- Trial name
- NCT02437461
- Testing
- Triamcinolone hexacetonide
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Uppsala University
Chronic Knee Pain, Chronic Pain
Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain
This clinical investigation will be carried out as a randomized controlled trial conducted at the Northern Regional Hospital, Hjørring.
- Conditions
- Chronic Knee Pain, Chronic Pain, Osteoarthritis
- Trial name
- RELEARN (NCT05335486)
- Testing
- RELEARN Neurofeedback, Standard care control
- Where
- Denmark
- Sponsor
- Redo-Neurosystems
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis, Ankylosing Spondylitis
Safety and Efficacy of Capsule FMT in Treatment-naïve Patients With Newly Diagnosed Chronic Inflammatory Diseases
PURPOSE: The main purpose is to explore clinical efficacy and safety associated with capsule FMT (cFMT) performed in newly diagnosed, untreated patients with rheumatic and gastrointestinal chronic inflammatory diseases (CIDs).
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Crohn Disease
- Trial name
- FRONT (NCT04924270)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Knee Pain Chronic
Quantum Molecular Resonance (QMR) Rehabiltative Treatment of Knee Osteoarthritis
Gonarthrosis (osteoarthritis of the knee (OA) is a chronic-degenerative disease, characterized by progressive joint damage up to disability that affects about 40% of people over 65 years of age.
- Trial name
- QMR (NCT06239805)
- Testing
- QMR
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- G. d'Annunzio University
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Gout
A Study of the Efficacy of Canakinumab in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy (Core Study) and a Long-term Study of the Efficacy and Safety of Canakinumab in Patients With Gout (Extension Study)
The 24-week, dose-ranging, multi-center, double-blind, double-dummy, active-controlled core study investigated the prophylactic effect of canakinumab on the signs and symptoms of acute flares in chronic gout patients initiating…
- Trial name
- NCT00819585
- Testing
- Canakinumab, Colchicine, Allopurinol
- Where
- 89 sites in United States, Argentina and 16 more
- Volunteers
- 432 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis
A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis
This study is comparing 200 milligrams (mg) of filgotinib a day with a placebo to see if filgotinib helps to treat Axial Spondyloarthritis (axSpA) and is safe to use.
- Trial name
- OLINGUITO (NCT05785611)
- Testing
- Filgotinib
- Where
- 123 sites in Belgium, Bulgaria and 16 more
- Volunteers
- 495 people
- Sponsor
- Alfasigma S.p.A.
Spondylarthropathies
Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis
The purpose of this study is to determine the mechanism of action on target tissue level of anti Interleukine-17 (anti-IL-17) an therapy in peripheral spondyloarthritis.
- Trial name
- MoA aIL-17 (NCT03358134)
- Testing
- Secukinumab
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Musculoskeletal Pain, Chronic Pain
The PROACTIVE Study for Black Elders
Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities.
- Conditions
- Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic
- Trial name
- PROACTIVE (NCT06512727)
- Testing
- PROACTIVE Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Depression, Anxiety
Web-based CBT for Symptoms of Mild-to-Moderate Anxiety and Depression in Youth With Chronic Illness
Symptoms of anxiety and depression are common in adolescents and young adults with chronic illnesses and are associated with decreased adherence to medical regimens.
- Conditions
- Depression, Anxiety, Inflammatory Bowel Disease, Systemic Lupus Erythematosus
- Trial name
- NCT02453880
- Testing
- Web-based Cognitive Behavioral Therapy
- Volunteers
- 14 people
- Sponsor
- Stanford University
Gout, Acute Gout Flare
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ABP-745 Administration in Healthy Volunteers
A randomized, double-blind, placebo-controlled, dose-escalation study will be conducted in healthy volunteers. This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ABP-745 following single (Part 1) and…
- Conditions
- Gout, Acute Gout Flare, Gout Flares
- Trial name
- ABP-745 (NCT06258213)
- Testing
- ABP-745
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Atom Therapeutics Co., Ltd
Chronic Pain, Osteoarthritis
Acupuncture Approaches for Chronic Pain
Chronic pain is a major public health problem that places many burdens on individuals, including impairment of physical and psychological functioning, lost productivity, and side effects of medications used to treat pain.
- Conditions
- Chronic Pain, Osteoarthritis, Neck Pain, Back Pain
- Trial name
- AADDOPT-2 (NCT02456727)
- Testing
- Group/Community Acupuncture, Individual Acupuncture
- Where
- United States
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Rheumatoid Arthritis, Chronic Periodontitis
Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical Parameters Among Patients Having Mild Rheumatoid Arthritis With Periodontitis
Purpose: To evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to non-surgical periodontal therapy on the clinical periodontal and biochemical parameters among patients with rheumatoid arthritis (RA) having…
- Trial name
- NCT05122117
- Testing
- Methylene blue mediated Photodynamic therapy, Non-surgical periodontal therapy
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Zohaib Akram
Knee Pain Chronic
Efficacy of Genicular Nerve Alcohol Neurolysis in Knee Osteoarthritis Pain
This study aimed to evaluate the efficacy of genicular nerve alcohol neurolysis in the treatment of pain caused by chronic knee osteoarthritis.
- Trial name
- NCT06060678
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Diskapi Teaching and Research Hospital
Knee Osteoarthritis
Influence of Noxious Electrical Stimulation on Chronic Pain From Knee Osteoarthritis
Knee osteoarthritis (OA) is the most common lower extremity joint pain condition, and it is estimated that 15 million people in the US are living with symptomatic knee OA and that more than half (8 million) are under 65 years of…
- Trial name
- NCT04628013
- Testing
- Noxious Electrical Stimulation (NxES)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of New England
Acute Gouty Arthritis
Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease
The purpose of this study is to confirm the efficacy and safety results obtained in a chronic kidney disease (CKD) subgroup of patients participating in Phase III studies in a larger, independent patient population with difficult…
- Trial name
- NCT01593527
- Testing
- ACZ885, Triamcinelone acetonide
- Sponsor
- Novartis Pharmaceuticals