Clinical trials: Chronic Arthritis
Spondylitis, Ankylosing
Extension in AS: Sustainability of Benefits, Safety and Tolerability
This 3-year extension study aims at making available the treatment with secukinumab in prefilled syringes (PFS) to patients with ankylosing spondylitis who took part in phase III study CAIN457F2305, defined as "core study", as…
- Trial name
- MEASURE 1 ext (NCT01863732)
- Testing
- Secukinumab
- Where
- 56 sites in United States, Belgium and 12 more
- Volunteers
- 274 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Acupuncture as an Adjunctive Therapy to the Pharmacological Treatment in Patients With Chronic Pain in Osteoarthritis of the Knee: a Three Armed Randomized Placebo Controlled Trial
The objective of this study is to assess the efficacy of acupuncture as an adjunctive therapy to pharmacological treatment of chronic pain due to knee osteoarthritis, as well as for, the improvement of physical functioning…
- Trial name
- NCT01398930
- Testing
- acupuncture
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- National and Kapodistrian University of Athens
Chronic Uncontrolled Gout, Gout
Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate
The purpose of this study is to assess the safety, tolerability and efficiency of pegloticase administered with a shorter infusion duration in participants with uncontrolled gout receiving methotrexate.
- Conditions
- Chronic Uncontrolled Gout, Gout, Uncontrolled Gout
- Trial name
- NCT04511702
- Testing
- Pegloticase with MTX
- Where
- 39 sites in United States
- Volunteers
- 191 people
- Sponsor
- Amgen
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
This study will explore the diverse health beliefs and behaviors among minority patients with rheumatic diseases. These diseases may cause joint pain, stiffness or swelling. Some can involve bones, muscles, tendons or ligaments.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Arthritis
- Trial name
- NCT00069342
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Knee Osteoarthritis, Knee Pain Chronic
Two-level ESPB in Total Knee Arthroplasty
Effect of two-level ESPB in Total Knee Arthroplasty
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT06470542
- Testing
- 2 x 20 ml of Ropivacaine 0.2% Injectable Solution, 2 x 20ml of Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis (OA), Chronic Pain
Individual Differences in Gait and Osteoarthritis Pain
The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance.
- Conditions
- Knee Osteoarthritis (OA), Chronic Pain, Chronic Knee Pain
- Trial name
- INDIGO (NCT07308873)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Knee Osteoarthritis, Knee Pain Chronic
The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the most common degenerative joint disease with pathological structural and functional disorders all over the world. 27 million patients diagnosed with osteoarthritis in the USA alone.(1-2)
- Trial name
- NCT05211544
- Testing
- physical therapy modalities and exercise, kinesio taping and exercise, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Arthritis, Asthma
Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems
Behavioral problems are part of many of the chronic diseases that cause the majority of illness, disability and death. Tobacco, diet, physical inactivity, alcohol, drug abuse, failure to take treatment, sleep problems, anxiety…
- Conditions
- Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes
- Trial name
- IBHPC (NCT02868983)
- Testing
- Integration
- Where
- United States
- Volunteers
- 4,025 people
- Sponsor
- University of Vermont
Chronic Heart Disorder, Lung Disorder
Wheeled Mobility in Everyday Life
The project will examine how mobility performance in real life tasks and environments is impacted by the use of specific types of wheeled mobility devices (wheeled walker, manual wheelchair, power wheelchair/scooter).
- Conditions
- Chronic Heart Disorder, Lung Disorder, Arthritis
- Trial name
- RERC-4a (NCT00981344)
- Testing
- Wheeled Mobility in Everyday Life:Effects of Wheelchair Type on Mobility Performance of Elders in Public Environments
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Ankylosing Spondylitis, Low Back Pain
The Effect of Acupuncture in Treating Chronic Low-back Pain
The purpose of this study is to evaluate the efficiency of acupuncture in treating chronic low-back pain
- Trial name
- NCT02260284
- Testing
- Yaotong points acupuncture, the usual care, standardized acupuncture
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chengdu PLA General Hospital
Osteoarthritis
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
This study will examine the effectiveness of injected hylan (Synvisc) for treating pain associated with osteoarthritis of the temporomandibular joint (jaw joint) and improving function of the joint.
- Trial name
- NCT00078351
- Testing
- High molecular weight hylan (Synvisc) injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.
- Conditions
- Pulmonary Fibrosis, Progressive Pulmonary Fibrosis, Pulmonary Fibrosis Secondary to Systemic Sclerosis, Pulmonary Fibrosis, Interstitial Lung Disease
- Trial name
- NCT06329401
- Testing
- AP01
- Where
- 154 sites in United States, Argentina and 12 more
- Volunteers
- 398 people
- Sponsor
- Avalyn Pharma Inc.
Osteoarthritis
An Efficacy, Safety and Effects on Quality of Life of Tramadol/Paracetamol as Add-on Therapy in Chronic Osteoarthritis
The purpose of this study is to evaluate the efficacy, safety and effects on Quality of Life (QOL) of tramadol/paracetamol (APAP) as an add-on therapy (medication taken in addition to another medication) in Filipino participants…
- Trial name
- NCT01728246
- Testing
- Tramadol/Paracetamol (APAP), Non-Tramadol/APAP
- Where
- Philippines
- Volunteers
- 473 people
- Sponsor
- Janssen Pharmaceutica
Chronic Wrist Pain, Chronic Elbow Pain
Effect of Celliant Materials on Pain and Blood Oxygenation in Subjects With Chronic Elbow and Wrist Pain
The purpose of this research is to determine whether a new type of fabric, Celliant, can reduce elbow and wrist pain associated with chronic medical conditions such as carpel tunnel syndrome, arthritis or tennis elbow and whether…
- Trial name
- NCT00688220
- Where
- United States
- Sponsor
- Southern California Institute for Research and Education
Arthritis of the Knee
Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis
This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid…
- Trial name
- NCT02437461
- Testing
- Triamcinolone hexacetonide
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Uppsala University
Arthritis, Pain
Intra-articularInjection of Botulinum Toxin Type
The purpose of this study is to determine whether intra-articular injection of botulinum toxin is effective in the treatment of chronic knee paindue to arthritis.
- Trial name
- NCT00211679
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Chronic Pain, PERIPHERAL NEUROPATHY
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
- Conditions
- Chronic Pain, PERIPHERAL NEUROPATHY, Occipital Neuralgia, Chronic Hip Pain
- Trial name
- NCT07639060
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Rheumatoid Arthritis, Chronic Hepatitis B
Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background
The purpose of this study is to investigate whether the combination of abatacept along with entecavir (the study drugs) is safe and effective in treating symptoms related to rheumatoid arthritis (RA).
- Trial name
- RA (NCT02053727)
- Testing
- Abatacept
- Where
- United States
- Sponsor
- University of California, Los Angeles
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Juvenile Idiopathic Arthritis, Diabetes
Health and Exercise Response in Children With Chronic and Auto-immune Pathologies
The aim of the present project is to assess the effects of the chronic diseases and their associated treatments chronic paediatric diseases (CPD), to further understand their impact on physical fitness for public health…
- Conditions
- Juvenile Idiopathic Arthritis, Diabetes, Inflammatory Bowel Disease, Cancer Survivor
- Trial name
- HERCCULE (NCT03913962)
- Testing
- indirect calorimetry
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand