Clinical trials: Chronic Arthritis
Osteoarthritis, Knee, Chronic Pain
Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients
Intra-articular injection of corticosteroid and hyaluronic acid is a common treatment for osteoarthritis of the knee. As a treatment drug for patients with depression, duloxetine has been shown in many studies to effectively…
- Trial name
- NCT04117893
- Testing
- Duloxetine, intra-articular injection of corticosteroid and hyaluronic acid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- PRO-RIC (NCT04528355)
- Testing
- data collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Paul Szabolcs
Chronic Conditions, Arthritis
I Am Able: Population Based Rehabilitation in a Family Health Team
People who have long-term conditions such as heart disease, diabetes, arthritis etc. face challenges in staying active and able to participate in activities that are important to them.
- Conditions
- Chronic Conditions, Arthritis, Diabetes, Hypertension
- Trial name
- NCT00859638
- Testing
- Physiotherapy, Occupational Therapy, Capacity Building
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Hamilton Health Sciences Corporation
Spondyloarthritis
The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis
This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a multicentric, non randomized prospective study aiming to better understand the mechanisms of the response…
- Trial name
- SpA23 (NCT05290363)
- Testing
- Blood sampling, synovial aspiration
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- Institut Pasteur
Osteoarthritis, Knee, Osteoarthritis, Hip
Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use"
To determine whether "continuous use" of celecoxib over a 6-month period is more efficacious than "usual or intermittent use" in preventing spontaneous osteoarthritis flares of the knee and hip.
- Trial name
- NCT00139776
- Testing
- Celecoxib
- Where
- 124 sites in United States, Belgium and 6 more
- Volunteers
- 875 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Osteo Arthritis Knee
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis
The purpose of this study is to test safety and efficacy of study drug LY3526318 in for the treatment of knee pain due to with osteoarthritis (OA).
- Trial name
- NCT05080660
- Testing
- LY3526318
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 160 people
- Sponsor
- Eli Lilly and Company
Diabetic Foot, Chronic Osteomyelitis
Predictive Value of Nu.Q™ Biomarkers to Help Guiding the Management of Osteoarticular Infections
Diabetic foot ulcers are frequent with average lifetime risk of 15%, and can lead to bone and joint infections. Current protocols for their management include evaluation of ischemia, assessment of underlying bone infection, sharp…
- Conditions
- Diabetic Foot, Chronic Osteomyelitis, Septic Arthritis
- Trial name
- NCT05593874
- Testing
- Histones H3.1 blood levels
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Neurodegenerative Diseases, Osteoarthritis
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions
To evaluate for any adverse effects that may be related to the administration and reception of autologous adipose derived stromal vascular fraction (SVF).
- Conditions
- Neurodegenerative Diseases, Osteoarthritis, Erectile Dysfunction, Autoimmune Diseases
- Trial name
- NCT01953523
- Testing
- Administration of autologous adipose derived SVF
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Elliot Lander
Gout, Chronic Kidney Diseases
Anakinra vs. Steroids for the Treatment of Gout Attacks in Patients With Renal Disease (ASGARD): A Feasibility Study
The aim of this study is to determine the feasibility of running a phase III double-blind, double-dummy randomised controlled trial comparing Depo-Medrone 120mg intramuscular injection vs.
- Trial name
- ASGARD (NCT02578394)
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mid and South Essex NHS Foundation Trust
Chronic Pain
Treatment of Chronic Pain From Osteoarthritis
Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in…
- Trial name
- NCT02032927
- Testing
- Codeine/paracetamol, Oxycodone/naloxone
- Where
- 14 sites in Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Osteoarthritis of the Knee, Chronic Lower Back Pain
A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of the study is to evaluate the analgesic efficacy of ASP7962 relative to placebo. This study will also evaluate the efficacy of ASP7962 relative to placebo on pain on walking, function and stiffness; the time course…
- Trial name
- OAK (NCT02611466)
- Testing
- ASP7962, Naproxen
- Where
- 34 sites in Belgium, Czechia and 4 more
- Volunteers
- 215 people
- Sponsor
- Astellas Pharma Europe B.V.
Hip Arthropathy, Hip Osteoarthritis
NLR and PLR Levels Following PENG Block in Hip Arthroplasty
Effect of PENG block on NLR and PLR following hip arthroplasty
- Conditions
- Hip Arthropathy, Hip Osteoarthritis, Hip Pain Chronic
- Trial name
- NCT07023107
- Testing
- 0.9% Sodium Chloride Injection, Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Reactive Arthritis
New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis
1. to investigate, whether one of the two alternative therapy strategies (antibiotic plus immunostimulation versus antibiotic plus immunosuppression) in chronic reactive arthritis is therapeutical superior to conventionel…
- Trial name
- NCT00244179
- Testing
- interferon-gamma, infliximab, dmard
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Knee Osteoarthritis, Arthropathy of Knee Joint
Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia
Previous retrospective database studies suggest that total knee arthroplasty (TKA) surgery under spinal anesthesia has less complications than when performed under general anesthesia.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid Arthritis
- Trial name
- NCT03364088
- Testing
- Spinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet
- Where
- Finland
- Volunteers
- 402 people
- Sponsor
- Riku Antero Palanne
Osteoarthritis
Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis
This study is being done to test the safety and efficacy of LY3016859 for the treatment of osteoarthritis pain. This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to accelerate…
- Trial name
- NCT04456686
- Testing
- LY3016859
- Where
- 33 sites in United States, Puerto Rico
- Volunteers
- 117 people
- Sponsor
- Eli Lilly and Company
Gout, Renal Insufficiency, Chronic
Genetic of Chronic Kidney Disease and Gout in New Caledonia
The goal of this research is to study the associations of genetic variants of gout and kidney failure, which are very common in the Melanesian population in New Caledonia
- Trial name
- CALEDGOUTCKD (NCT05607797)
- Testing
- Epidemiological study
- Where
- New Caledonia
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoporosis, Chronic Respiratory Disease
Collaborative Care With Smart Health Management Program for Patients With Chronic Illness
This study verifies efficacy of collaborative care with Smart Health Management Program developed for patients with chronic illness.
- Conditions
- Osteoporosis, Chronic Respiratory Disease, Arthritis, Osteopenia
- Trial name
- NCT03294057
- Testing
- Tele-coaching programs, ICT programs, A book about chronic disease
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis of the Knee, Degenerative Osteoarthritis
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the…
- Conditions
- Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
- Trial name
- PRPNSAIDsKOA (NCT05742763)
- Testing
- Ibuprofen and PRP, Acetaminophen and PRP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QC Kinetix LLC
Osteoarthritis
Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) (5, 10 and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00313846
- Testing
- Buprenorphine transdermal patch
- Where
- 44 sites in United States
- Volunteers
- 529 people
- Sponsor
- Purdue Pharma LP