Clinical trials: Chronic Back Pain
Neuropathic Pain
Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain
Based on laboratory studies, donepezil will improve pain relief more than placebo in patients with chronic neuropathic pain who are currently taking gabapentin or pregabalin.
- Trial name
- NCT01743976
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University
Chronic Low Back Pain, Chronic Neck Pain
Effect of Combined Morphine and Duloxetine on Chronic Pain
A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use.
- Trial name
- Duloxetine (NCT03249558)
- Testing
- Morphine, Duloxetine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Low Back Pain
Selecting Effective Combinations of Treatment for Low Back Pain
Back pain is the #1 contributor to disability in the United States (US), and second only to hearing problems as a reason for new Veteran disability compensation.
- Trial name
- SELECT LBP (NCT03520387)
- Testing
- Lumbar medial branch nerve radiofrequency ablation (LRFA), Simulated LRFA with targeted steroid injections, AcTIVE-CBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Chronic Low-back Pain
VANISH for Chronic Low Back Pain
The program, called TMC-CP01, will use a combination of virtual reality, biofeedback, and psychological exercises to manage pain associated with Chronic Low Back Pain.
- Trial name
- VANISH (NCT04236804)
- Testing
- Flowly (TMC-CP01)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ajay Wasan, MD, Msc
Low Back Pain
Education/Exercise and Chiropractic for Chronic Back Pain
As a needed first step prior to a planned full-scale RCT, in order to assess the feasibility of the RCT and refine its design and protocols, we will perform a pilot study with the following objectives:1.To assess whether enough…
- Trial name
- NCT00561652
- Testing
- Education & Exercise, Chiropractic treatment (plus Education & Exercise)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- US Department of Veterans Affairs
Low Back Pain, Opiate Addiction
Study of Opioid Use After Lumbar and Cervical Spine Surgery
The purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery.
- Conditions
- Low Back Pain, Opiate Addiction, Neck Pain
- Trial name
- SOULCS (NCT02674711)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Chronic Low Back Pain With a Neuropathic Component
Efficacy and Safety Study of Celecoxib and Pregabalin Compared With Celecoxib Monotherapy, in Patients With Chronic Low Back Pain Having a Neuropathic Component
The purpose of this study is to determine if treatment with celecoxib and pregabalin together would prove to be more effective in relief of pain than treatment with celecoxib alone in people who have chronic low back pain with a…
- Trial name
- NCT01838044
- Testing
- pregabalin and celecoxib
- Where
- 29 sites in Brazil, Chile and 5 more
- Volunteers
- 180 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Depressive Disorder, Back Pain
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults
The following primary hypotheses will be tested: 1. During Step 1: Major Depressive Disorder (MDD) or Chronic Low Back Pain (CLBP) in < 40% of the initial 60 subjects treated with duloxetine (DUL) + Clinical Management(CM) during…
- Conditions
- Major Depressive Disorder, Back Pain, Aged
- Trial name
- ACHIEVE2 (NCT00696293)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Chronic Low-back Pain
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Chronic Low Back Pain
The purpose of this study is to test whether LY3526318 is efficacious and safe in relieving chronic low back pain (CLBP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to…
- Trial name
- NCT05086289
- Testing
- LY3526318
- Where
- 31 sites in United States, Puerto Rico
- Volunteers
- 159 people
- Sponsor
- Eli Lilly and Company
Lower Back Pain
Investigation of Efficacy of Botulinum Toxin A (Dysport) in Chronic Low Back Pain
The scientific aim of this study is to investigate the efficacy of abobotulinumtoxinA (Dysport - Ipsen Pharmaceuticals) in chronic low back pain.
- Trial name
- NCT02221648
- Testing
- AbobotulinumtoxinA Treatment
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Yale University
Low Back Pain, Pain
D-cycloserine for the Treatment of Chronic, Refractory Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of D-cycloserine versus placebo in relieving the signs and symptoms of patients with chronic lower back pain.
- Trial name
- NCT03535688
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Northwestern University
Chronic Low Back Pain
Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure
Almost one-third (30%) of persons 60 years and older suffer from cLBP and cause a significant negative impact on individuals and society in the U.S.
- Trial name
- NCT03589703
- Testing
- Target ear points related to chronic low back pain (T-APA), Non-Target ear Points not related to chronic low back pain (NT-APA), Enhanced Educational Control Group (CG-2)
- Where
- 2 sites in United States
- Volunteers
- 272 people
- Sponsor
- The University of Texas Health Science Center, Houston
Low Back Pain
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients
Low back pain (LBP) is a common problem among US adults. Initial episodes tend to be self-limited ("acute"), but some people can progress to a state of persistent pain.
- Trial name
- TARGET (NCT02647658)
- Testing
- Guideline Based Care plus Psychologically Informed Physical Therapy, Guideline Based Care (GBC)
- Where
- 5 sites in United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pittsburgh
Chronic Low Back Pain
Implementation of Pedometer for Monitoring Step Count Pre and Post Lumbar ESI for Radicular Pain
Our aim is to assess usability and compliance of a wireless pedometer for monitoring step count after a lumbar epidural steroid injection for the treatment of radicular pain in low back pain patients.
- Trial name
- NCT02356783
- Testing
- Pedometer
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Hospital for Special Surgery, New York
Chronic Low-back Pain, Postsurgical Pain
Postoperative Telehealth Mindfulness Intervention After Spine Surgery
Lumbar spine pain is the leading cause of years lived with a disability and affects over 50 million individuals in the United States.
- Conditions
- Chronic Low-back Pain, Postsurgical Pain, Opioid Use, Lumbar Spine Surgery
- Trial name
- NCT04648683
- Testing
- Individual telehealth mindfulness, Group telehealth mindfulness
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Discogenic Pain, Low Back Pain
Intradiscal Platelet Rich Plasma
To assess changes in pain and function in patients with discogenic low back pain after a standard of care intradiscal injection of Platelet-Rich Plasma (PRP).
- Conditions
- Discogenic Pain, Low Back Pain, Chronic Pain
- Trial name
- NCT04544709
- Testing
- Low back intradiscal injection of platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Low Back Pain
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
Duloxetine has recently been shown to be effective in reducing the pain in chronic pain patients. Duloxetine is known to exert a central mechanism, however the precise human brain structures responsible for mediating its…
- Trial name
- NCT00388414
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Low Back Pain
Auricular Vagus Nerve Stimulation for Chronic Pain
This proposal aims to investigate the treatment effect and underlying mechanism of transcutaneous acupuncture stimulation on chronic low back pain.
- Trial name
- NCT03959111
- Testing
- Stimulation at Location 1, Stimulation at Location 2
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Pain, Back Pain
Development of STEPPT
This 6-month pilot study aims to assess the feasibility, acceptability, and estimate effect sizes of the pilot STEPPT intervention for addressing ethnic disparities in physical therapy referrals and adherence between Hispanic and…
- Conditions
- Pain, Back Pain, Low Back Pain, Chronic Pain
- Trial name
- STEPPT PILOT (NCT06835439)
- Testing
- STEPPT Pilot, Standard Care (Control)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- San Diego State University
Pain, Chronic Pain
Effect of Pulse Width With Spinal Cord Stimulation
The primary objective of this study is to assess the effects of varying pulse width in suprathreshold dorsal column stimulation in patients with low back pain.
- Conditions
- Pain, Chronic Pain, Back Pain
- Trial name
- NCT00399516
- Testing
- Precision
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Boston Scientific Corporation