Clinical trials: Chronic Back and Leg Pain
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Low Back Pain
Treatment of Chronic Low Back and Lower Extremity Pain
1. To demonstrate clinically significant improvements in patients undergoing lumbar interlaminar epidurals. Improvement will be assessed in relation to the clinical outcome measures of pain and function. 2.
- Trial name
- NCT00681447
- Testing
- Lumbar Interlaminar Epidural, Lumbar Interlaminar Epidural injection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pain Management Center of Paducah
Chronic Pain, Back Pain
ECAP-controlled, Closed-loop Stimulation to Treat Chronic Trunk and/or Limb Pain (ECAP)
The purpose of this study is to evaluate neurophysiological measures and clinical outcomes of the Evoke System to treat trunk and/or limb pain in a real-world population.
- Conditions
- Chronic Pain, Back Pain, Pain
- Trial name
- ECAP (NCT04319887)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 22 sites in United States
- Volunteers
- 300 people
- Sponsor
- Saluda Medical Pty Ltd
Back Pain, Back Pain With Radiation
Sub-Sensory Intraspinal Neurostimulation Therapy
To explore the optimal stimulation parameters and locations for sub-perception programming in patients with previously implanted spinal cord stimulation systems for the treatment of chronic back and/or leg pain.
- Conditions
- Back Pain, Back Pain With Radiation, Pain in Leg, Unspecified
- Trial name
- NCT01976598
- Testing
- Sub-Sensory Stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Algos Clinical Development Thomas L. Yearwood, MD, PhD
Chronic Low-back Pain
Comparative Effects of Mulligan Straight Leg Raise Technique Versus Slump Stretching on Pain, Disability and Hip Range of Motion in Patients With Chronic Low Back Pain.
The goal of this clinical trial is to examine the effect of mulligan straight leg raise versus slump stretching on pain, disability and hip range of motion in patient with low back pain. .
- Trial name
- NCT05779891
- Testing
- Mulligan Traction Straight Leg Raise Technique, Slump Stretching
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Pain
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Instructions for Use and…
- Trial name
- RELIEF (NCT01719055)
- Testing
- neurostimulation system
- Where
- 118 sites in United States, Argentina and 14 more
- Volunteers
- 4,800 people
- Sponsor
- Boston Scientific Corporation
Low Back Pain
Manual Therapy as a Form of Sensory Discrimination in Chronic Low Back Pain
This study evaluates whether different explanations given to patients with long lasting back pain influence a physical therapy treatment technique.
- Trial name
- NCT02757378
- Testing
- Neuroplasticity Explanation (Experimental), Biomechanical Explanation (Control)
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Kevin Farrell
Spinal; Nerve Root, Pain, Pelvic Pain
Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain
ACTIVE study- a prospective observational clinical study examining the changes in quality of life and pain following dorsal root ganglion stimulation for the treatment of chronic intractable pelvic and lower limb pain.
- Conditions
- Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome
- Trial name
- ACTIVE (NCT03417973)
- Testing
- dorsal root ganglion neuromodulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- KM Clinical Research Group
Chronic Refractory Low Back and Leg Pain
Prospective Randomized Feasibility Study Comparing Manual vs. Automatic Position-Adaptive Spinal Cord Stimulation With Surgical Leads
The main purpose of this study is to establish the extent that chronic pain patients implanted with surgical, laminectomy-type, leads experience position-related variation in spinal cord stimulation therapy and to investigate the…
- Trial name
- RestoreSensor (NCT01874899)
- Testing
- RestoreSensor Neurostimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Justin Parker Neurological Institute
Chronic Pain
A Study to Evaluate the Effect of Precision Spectra™ Programming Features and Lead Options on Patient Outcomes
The study is a prospective, on-label, multi-center, blinded, randomized controlled trial with a cross-over design to evaluate the effect of Precision Spectra™ SCS System's programming features and lead options.
- Trial name
- COVERAGE (NCT02384096)
- Testing
- Conventional single source programming, Precision Spectra SCS System advanced programming
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Boston Scientific Corporation
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Sub-acute and Chronic Back-related Leg Pain
Chiropractic and Self-care for Back-Related Leg Pain
The primary aims of the project are to determine the clinical efficacy of chiropractic Spinal Manipulative Therapy (SMT) plus self-care education versus self-care education alone in 192 patients with sub-acute and chronic Back…
- Trial name
- NCT00494065
- Testing
- Home exercise, Chiropractic Spinal Manipulative Therapy + Home exercise
- Where
- 2 sites in United States
- Volunteers
- 192 people
- Sponsor
- Northwestern Health Sciences University
Low Back Pain
Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients
To evaluate the effectiveness of steroids and/or 10% hypertonic sodium chloride in percutaneous adhesiolysis in managing chronic low back and/or lower extremity pain in patients with post lumbar surgery syndrome.
- Trial name
- NCT01053572
- Testing
- Adhesiolysis
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Pain Management Center of Paducah
Chronic Back and Leg Pain
Investigation of the Effect of a Virtual Reality-Based Back School Program on Pain, Functionality, and Kinesiophobia
This study investigates the effects of a 4-week virtual reality (VR)-based back school program on pain, disability, fear of movement, and lumbar joint position sense (JPS) in individuals with chronic low back pain.
- Trial name
- NCT07492784
- Testing
- Back school education integrated with a VR headset
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University
Pain, Chronic, Pain, Intractable
Spinal Cord Stimulation in the Treatment of Chronic, Intractable Pain Using the Nalu™ Neurostimulation System
The Nalu Neurostimulation System is capable of delivering multiple therapy options to address patient needs. The study will confirm the efficacy, safety, comfort and compliance with the Nalu Neurostimulation System in adult…
- Conditions
- Pain, Chronic, Pain, Intractable, Pain, Back
- Trial name
- nPower™-US (NCT04503109)
- Testing
- Nalu Neurostimulation System
- Where
- 8 sites in United States
- Volunteers
- 110 people
- Sponsor
- Nalu Medical, Inc.
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Failed Back Surgery Syndrome, Complex Regional Pain Syndrome (CRPS)
A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain
This study is a prospective, single-arm, open label, single center pilot study to confirm the safety of a ultrahigh frequency DRG stimulator in patients with chronic lower limb pain. The actual trial length is 5 days.
- Trial name
- NCT03285113
- Testing
- GiMer Medical MN 1000 External Stimulator
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GiMer Medical
Chronic Pain, Back Pain
Value of Multiple Modalities Using the Spectra WaveWriter Spinal Cord Stimulator System
To demonstrate the value of multiple modalities and sustained clinically significant pain relief in patients with chronic pain when using the Boston Scientific Spectra WaveWriter Spinal Cord Stimulator (SCS) System.
- Trial name
- VERITAS (NCT03251937)
- Testing
- Spectra WaveWriter SCS System
- Where
- 15 sites in United States
- Volunteers
- 97 people
- Sponsor
- Boston Scientific Corporation
Complex Regional Pain Syndrome (CRPS)
TARGET Post-Approval Study
The purpose of this prospective, multicenter, single arm post-approval study is to demonstrate continued safety of the Axium and Proclaim Neurostimulator System for dorsal root ganglion (DRG) stimulation.
- Trial name
- TARGET PAS (NCT02800863)
- Testing
- Dorsal Root Ganglion (DRG) Stimulation (Axium™ Neurostimulator System), Dorsal Root Ganglion (DRG) Stimulation (Proclaim™ Neurostimulator System)
- Where
- 44 sites in United States
- Volunteers
- 426 people
- Sponsor
- Abbott Medical Devices
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego