Clinical trials: Chronic Condition
Cerebral Palsy, Periventricular Leukomalacia
A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy
UDI-001 is administered to pediatric patients with cerebral palsy attributed to periventricular leukomalacia (PVL) multiple times to investigate its safety and efficacy.
- Trial name
- NCT04873752
- Testing
- UDI-001
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Rohto Pharmaceutical Co., Ltd.
Tension-Type Headache
Gonyautoxin in the Treatment of Chronic Tension-Type Headache
The purpose of this study is to evaluate the clinical efficacy of Gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache in accordance with International Headache Society guidelines
- Trial name
- NCT00276952
- Testing
- Gonyautoxin
- Where
- Chile
- Volunteers
- 27 people
- Sponsor
- University of Chile
Pulmonary Disease, Chronic Obstructive
Effect of Acupuncture on Patients With Chronic Obstructive Pulmonary Disease
This study aims to compare the efficacy of three therapies for chronic obstructive pulmonary disease (COPD) patients: one, conventional drug based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 and Chinese…
- Trial name
- NCT03169504
- Testing
- Acupuncture, Conventional drug, Acupuncture plus conventional drug
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Chronic Peritoneal Dialysis
Method of Exit Site Care in Chronic Peritoneal Dialysis Patients
Peritoneal dialysis accounts for more than 70% of the dialysis modality in Hong Kong. Exit site infection (ESI) is one of the causes leading to peritoneal catheter removal. Appropriate exit-site care can prevent ESI.
- Trial name
- NCT00416338
- Testing
- film dressing by adhesive
- Where
- Hong Kong
- Volunteers
- 11 people
- Sponsor
- Chinese University of Hong Kong
CRPS (Complex Regional Pain Syndromes), Radiculopathy
Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy
This study seeks to evaluate the use of intermittent dosing as an alternative paradigm for patients with DRG stimulation in place for at least 1 year and minimum 50% pain relief in the targeted area.
- Conditions
- CRPS (Complex Regional Pain Syndromes), Radiculopathy, Peripheral Neuropathy
- Trial name
- NCT04909138
- Testing
- DRG stimulation 20 Hz 30/90, DRG stimulation 5 Hz 30/90
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Chronic Pain, Pelvic Pain
Hypnotic Intervention for Women With Chronic Pelvic Pain
Objective: To establish whether the pilot online hypnosis design was well received by women with persistent pelvic pain and worthy of a full randomised control trial To establish whether hypnosis improves mental health outcomes…
- Conditions
- Chronic Pain, Pelvic Pain, Psychological, Hypnosis, Animal
- Trial name
- NCT04851626
- Testing
- Hypnotic intervention for persistent pelvic pain., Control group persistent pelvic pain no intervention.
- Where
- Australia
- Volunteers
- 14 people
- Sponsor
- University of South Australia
Leukemia
A Study to Investigate BAY2402234, a Dihydroorotate Dehydrogenase (DHODH) Inhibitor, in Myeloid Malignancies
The primary objective is to determine the safety, tolerability, pharmacokinetics, maximum tolerated dose (MTD), or pharmacological active dose (PAD) of BAY2402234 in patients with acute myeloid leukemia (AML), myelodysplastic…
- Trial name
- NCT03404726
- Testing
- BAY2402234
- Where
- 5 sites in United States, France
- Volunteers
- 40 people
- Sponsor
- Bayer
Chronic Pain
Peculiarities of Pain in Patients With Mine-explosive Wounds Depending on the Localization of the Wound at the Stages of Treatment
Mine-explosive wounds in the general structure of combat sanitary losses reach 25%. They are characterized by significant damage resulting in high intensity pain.
- Trial name
- PPPM-EWDL (NCT05485285)
- Testing
- visual analog scale
- Where
- Ukraine
- Volunteers
- 660 people
- Sponsor
- Bogomolets National Medical University
ESRD, CKD Stage 4
Safety and Efficacy of Canagliflozin in Advanced CKD
The study objective is to characterize the pharmacokinetics (PK), pharmacodynamics, and surrogate measures of efficacy for canagliflozin in patients with advanced CKD, including those receiving HD.
- Conditions
- ESRD, CKD Stage 4, CKD Stage 5
- Trial name
- SIP-AKiD (NCT05309785)
- Testing
- Invokana 300 mg and 100 mg tablet
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neck Pain
Chiropractic and Exercise for Seniors With Neck Pain
The purpose of this randomized clinical trial is to assess the relative effectiveness of three conservative treatment approaches for seniors with chronic neck pain: 1) chiropractic manual treatment plus home exercise, 2)…
- Trial name
- NCT00269308
- Testing
- Chiropractic Manual treatment + home exercise ( procedure+behavior), Supervised rehabilitative exercise + home exercise, Home exercise
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Northwestern Health Sciences University
Chronic Kidney Disease
Effects of Low Protein Diet Supplemented Keto-/Amino Acid in Preventing the Progression of Chronic Kidney Disease (CKD)- ELPD Study
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 3b and 4).
- Trial name
- ELPD-CKD (NCT01418508)
- Testing
- low protein diet plus α-keto acid, very low protein diet plus α-keto acid
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Periodontitis
Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects
Introduction- Oxidative stress plays a causative role in pathogenesis of periodontal disease. It has been reported that Spirulina platensis or its active ingredient C phycocyanin (CPC) exerts anti-inflammatory, anti-oxidative and…
- Trial name
- NCT02886676
- Testing
- Spirulina capsules
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Dacryocystitis, Dacryocystitis; Chronic
Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other
The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups.
- Conditions
- Dacryocystitis, Dacryocystitis; Chronic, Dacryocystorhinostomy, Epiphora
- Trial name
- NCT06810089
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Uludag University
Chronic Obstructive Pulmonary Disease
A 2 Week, Crossover Trial of Dietary Nitrate in Chronic Obstructive Pulmonary Disease
Acute consumption of dietary nitrate (as beetroot juice) has been shown to increase exercise and decrease systemic blood pressure in multiple populations, including COPD.
- Trial name
- NCT02521532
- Testing
- Dietary nitrate
- Where
- Ireland
- Volunteers
- 8 people
- Sponsor
- Royal College of Surgeons, Ireland
COPD
Morphine or Fentanyl for Refractory Dyspnea in COPD
Rationale: The most important complaint in severe COPD is dyspnea which is associated with a diminished exercise tolerance, reduced quality of life and can lead to anxiety and depression.
- Trial name
- MoreFoRCOPD (NCT03834363)
- Testing
- Fentanyl, Morphine Retard
- Where
- 10 sites in Netherlands
- Volunteers
- 59 people
- Sponsor
- Huib A.M. Kerstjens
Dyspnea, Unexplained Chronic Dyspnea
Establishing Clinical Utility for a New Diagnostic Test for Patients With Shortness of Breath
This study will collect high-quality data on how practicing specialist physicians, specifically cardiologists and pulmonologists, across the U.S.
- Trial name
- NCT04693793
- Testing
- Education Materials and Janssen Test
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Cerebrovascular Accident
Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients
This study will examine the effectiveness of an experimental treatment to improve hand function in patients who have had a stroke affecting one side of the body.
- Trial name
- NCT00006414
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease
Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI
Patients with coronary artery disease and undergoing high-risk percutaneous coronary intervention (PCI) are at increased risk of hemodynamic instability and poor outcomes.
- Conditions
- Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease, Coronary Artery Disease, Cardiogenic Shock
- Trial name
- POTOK (NCT07149714)
- Testing
- iVAC 2L
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Traumatic Brain Injury
Executive Function Training Intervention for Chronic Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a prevalent disorder developed by military personnel. While some individuals recover function within months after injury, others continue to suffer from cognitive problems months to years later and…
- Trial name
- NCT03704116
- Testing
- Expedition
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas at Dallas