Clinical trials: Chronic Constipation
Chronic Constipation, Constipation
Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
The purpose of this study is to evaluate the efficacy and safety of linaclotide compared with placebo in patients with chronic constipation (CC) and prominent abdominal bloating.
- Trial name
- NCT01642914
- Testing
- Linaclotide 290 micrograms, Linaclotide 145 micrograms
- Where
- 151 sites in United States, Canada
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Constipation
Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation
The purpose of this study is to determine which dose of prucalopride is safe and effective in patients with chronic constipation.
- Trial name
- NCT00631813
- Testing
- Prucalopride
- Volunteers
- 253 people
- Sponsor
- Movetis
Functional Constipation (FC), Chronic Idiopathic Constipation (CIC)
A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation
Functional constipation (FC) is a common healthcare problem in children of all ages, potentially due to genetic predisposition, inadequate fiber and fluid intake, and immobility.
- Trial name
- NCT05652205
- Testing
- Linaclotide
- Where
- 48 sites in United States, Bulgaria and 2 more
- Volunteers
- 123 people
- Sponsor
- AbbVie
Constipation, Chronic Idiopathic Constipation
BLI400-302: A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate a daily dose of BLI400 Laxative for safety and efficacy versus placebo in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819297
- Testing
- BLI400 Laxative
- Where
- 51 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Braintree Laboratories
Chronic Constipation
Exploring the Potential Benefits of Probiotic Yogurt
This study aims to evaluate the effect of a high-activity probiotic yogurt on improving symptoms of chronic constipation, observing its regulatory effects on the gut microbiota and the incidence of adverse reactions in study…
- Trial name
- NCT06847919
- Testing
- Probiotic yogurt group, Yogurt control group
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Chronic Constipation
Phase II, Randomized, Placebo-Controlled Study of ATI-7505 in Patients With Chronic Idiopathic Constipation
The purpose of this study is to determine whether ATI-7505 is effective in the treatment of chronic idiopathic constipation.
- Trial name
- NCT00501241
- Testing
- ATI-7505
- Where
- 23 sites in United States, Canada
- Volunteers
- 214 people
- Sponsor
- Procter and Gamble
Chronic Idiopathic Constipation (CIC)
Post-Marketing Study of Prucalopride Safety In Pregnancy
This study collects information on pregnant women with ongoing constipation who took prucalopride and those who did not take prucalopride.
- Trial name
- NCT04869280
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Takeda
Back Pain, Low Back Pain
Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
This was a clinical effectiveness trial designed to compare the effectiveness, safety, and tolerability of treatment with tapentadol prolonged release with that of oxycodone/naloxone prolonged release in non-opioid pre-treated…
- Conditions
- Back Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT01838616
- Testing
- Tapentadol Prolonged Release, Oxycodone/Naloxone Prolonged Release
- Where
- 50 sites in Austria, Germany and 2 more
- Volunteers
- 367 people
- Sponsor
- Grünenthal GmbH
Chronic Constipation
Effect of Tegaserod on Orocecal Transit in Elderly Chronic Constipation Patients
This study will evaluate the effects of tegaserod on orocecal and colonic transit in patients over 65 years with chronic constipation.
- Trial name
- NCT00348634
- Testing
- Tegaserod
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Novartis
Chronic Constipation
Effect of Prucalopride in Patients With Severe Chronic Idiopathic Constipation
The purpose of this study is to determine whether prucalopride is safe and effective in patients with severe chronic constipation.
- Trial name
- NCT00576511
- Testing
- prucalopride
- Volunteers
- 53 people
- Sponsor
- Movetis
Chronic Constipation
A Single-blind, Dose-tapering Study of KWA-0711 in Patients With Chronic Constipation
The purpose of this study is to evaluate the efficacy and safety of tapered KWA-0711 dose in chronic constipation patients.
- Trial name
- NCT01937663
- Testing
- KWA-0711
- Where
- Japan
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Infrequent Bowel Movements
Investigation of the Effects of a Bifidobacterial Strain on Bowel Movement in Healthy Adults
The goal of this clinical trial is to investigate whether a supplement containing the B. longum strain works to alleviate constipation in adults. The main questions it aims to answer are: Does a supplement containing the B.
- Trial name
- NCT06686420
- Testing
- B. longum
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Morinaga Milk Industry Co., LTD
Constipation
Double-Blind, Double-Dummy, 2-Period Crossover of a 20-Minute Versus a 4-hour IV of MOA-728 in Stable Methadone Subjects
MOA-728, an investigational drug, is currently being studied for the relief of constipation associated with postoperative ileus and treatment of opioid induced constipation in patients receiving palliative care.
- Trial name
- NCT00444158
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Constipation
Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain
The primary purpose of the protocol is to evaluate the safety, efficacy, and tolerability of subcutaneous MOA-728 versus placebo in subjects with chronic non-malignant pain who have Opioid-Induced Constipation (OIC).
- Trial name
- NCT00529087
- Testing
- N-methylnaltrexone bromide (MOA-728)
- Where
- 78 sites in United States
- Volunteers
- 460 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Chronic Constipation
Study to Investigate Prucalopride vs. Polyethylene Glycol 3350 on Colon Activity
To evaluate the different effects of prucalopride and PEG 3350 + electrolytes on colon motor activity in subjects that are chronically constipated.
- Trial name
- NCT01707667
- Testing
- prucalopride, PEG 3350
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 13 people
- Sponsor
- Shire
Opioid-induced Constipation
Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.
This study will evaluate the safety and efficacy of Tegaserod in opioid-induced constipation in patients with non-cancer pain. Patients who enter this study PRIOR to the core study (CHTF919N2201) interim analysis receive the…
- Trial name
- NCT00414024
- Testing
- Tegaserod
- Where
- 6 sites in United States, China and 4 more
- Volunteers
- 11 people
- Sponsor
- Novartis
Male Subjects With Chronic Constipation
Evaluation of Prucalopride in Male Subjects With Chronic Constipation.
This is a multi-centre, randomised, parallel-group, double-blind, placebo-controlled phase III trial to evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.
- Trial name
- NCT01147926
- Testing
- Prucalopride
- Where
- 73 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 374 people
- Sponsor
- Shire
Chronic Idiopathic Constipation
Elobixibat Colonic Motor Function Study
This is a randomized trial of 36 otherwise healthy patients with chronic idiopathic constipation. The purpose of the study is to compare the effects of daily single-dose oral elobixibat and placebo for 7 days on colonic motor…
- Trial name
- NCT02392546
- Testing
- elobixibat
- Where
- United States
- Sponsor
- Ferring Pharmaceuticals
Chronic Constipation
An Open Single Centre Study To Assess Treatment of Chronic Constipation in Children
The purpose of this study was to evaluate the safety and efficacy of Movicol in the treatment of chronic constipation in children.
- Trial name
- NCT00403897
- Testing
- Polyethylene glycol 3350 Na bicarbonate NaCl KCl
- Where
- Australia
- Volunteers
- 81 people
- Sponsor
- Norgine