Clinical trials: Chronic Constipation
Chronic Idiopathic Constipation
Efficacy and Safety Trial of Elobixibat in Patients With Chronic Idiopathic Constipation
12 Week Efficacy and Safety Trial Followed by a 4 Week Withdrawal Period for Patients with Chronic Idiopathic Constipation.
- Trial name
- NCT01833065
- Testing
- Elobixibat 10 mg/day, Elobixibat 5 mg/day
- Where
- 97 sites in United States, Brazil and 10 more
- Volunteers
- 314 people
- Sponsor
- Ferring Pharmaceuticals
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Chronic Idiopathic Constipation
A Postmarketing Study of Plecanatide in Breast Milk of Lactating Women Treated With TRULANCE®
This is a multi-center, open-label study evaluating pharmacokinetics of TRULANCE® (plecanatide) in breast milk of lactating women treated with TRULANCE
- Trial name
- NCT03551873
- Testing
- Plecanatide
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation
Trial to Evaluate the Efficacy and Safety of R093877 in Patients With Chronic Idiopathic Constipation
The purpose of the study is to determine whether prucalopride is safe and effective in patients with chronic idiopathic constipation.
- Trial name
- NCT00596596
- Testing
- prucalopride, 2 mg prucalopride, 4 mg prucalopride
- Volunteers
- 313 people
- Sponsor
- Movetis
Constipation
The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study
Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. There exist effective pharmacological therapies for chronic constipation, however, many patients do not well respond…
- Trial name
- NCT02726295
- Testing
- E. coli Nissle 1917(Mutaflor®)
- Where
- South Korea
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Constipation
Comparator Study of PEG 3350 Versus Prucalopride in Females With Chronic Constipation
This study is to compare the efficacy and safety of polyethylene glycol (PEG) 3350 with that of prucalopride in the treatment of chronic constipation in females.
- Trial name
- NCT01251822
- Testing
- PEG 3350 plus electrolytes, Prucalopride
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Norgine
Constipation, Constipation by Outlet Obstruction
The Impact of Aerobic Interval and Inspiratory Muscle Training On Patient Reported Outcome Scores In Individuals With Chronic Constipation
The primary aim of this study will be to determine if the addition of aerobic interval and inspiratory muscle training (IMT) targeted at improving cardiopulmonary-based measures will further improve patient satisfaction scores in…
- Conditions
- Constipation, Constipation by Outlet Obstruction, Constipation-predominant Irritable Bowel Syndrome, Constipation - Functional
- Trial name
- NCT05321953
- Testing
- Standard Physical Therapy Care, Aerobic and Inspiratory Muscle Training
- Where
- United States
- Sponsor
- University of Miami
Constipation
Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation
The main purpose of this study is to evaluate the tolerance of long term repeated doses of Forlax® 10g versus lactulose in elderly ambulatory or institutionalized patients, paying special attention to digestive and nutritional…
- Trial name
- NCT00276354
- Testing
- PEG 4000 (Forlax ®)
- Where
- 146 sites in France
- Volunteers
- 246 people
- Sponsor
- Ipsen
Aging, Constipation
Probiotics in Elderly Patients With Medical Conditions
Study of efficacy of probiotic in older patients with multiple co-morbidites and constipation
- Conditions
- Aging, Constipation, Multi-Core Disease
- Trial name
- Probiotics (NCT04035616)
- Testing
- microbial cell preparation [MCP]
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Constipation, Chronic Constipation
Balloon Inflation in Biofeedback
Chronic constipation, particularly due to dyssynergic defecation, is common and impacts quality of life. Biofeedback therapy (BFT) is the most effective conservative treatment, teaching patients to coordinate abdominal and anal…
- Conditions
- Constipation, Chronic Constipation, Dyssynergia, Anismus
- Trial name
- NCT07705542
- Testing
- Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Constipation
Investigation of the Additional Effects of Aerobic Exercise Training to Abdominal Massage in Functional Constipation
The aim of this study was to investigate the additional effects of aerobic exercise to abdominal massage in patients with functional constipation.
- Trial name
- NCT06298331
- Testing
- Aerobic Exercise, Abdominal Massage, Patient Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Chronic Idiopathic Constipation
SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation
This is a Phase 2a, randomized, double-blind, placebo-controlled, 14-day repeat oral, dose ranging study to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) effects of SP-304 in patients with chronic…
- Trial name
- CIC (NCT01053962)
- Testing
- SP-304 0.3 mg, SP-304 1.0 mg, SP-304 3.0 mg
- Where
- 14 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation, End Stage Renal Disease on Dialysis
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and…
- Trial name
- NCT04527640
- Testing
- Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Constipation
Efficacy and Safety Study of the Effect of Dose-Titration of Prucalopride for The Treatment of Chronic Constipation
The purpose of this study is to determine the safety profile of 4 mg prucalopride in the treatment of chronic constipation.
- Trial name
- NCT00577018
- Testing
- Prucalopride
- Volunteers
- 755 people
- Sponsor
- Movetis
Chronic Constipation
An Open Single Centre Study To Assess Treatment of Chronic Constipation in Children
The purpose of this study was to evaluate the safety and efficacy of Movicol in the treatment of chronic constipation in children.
- Trial name
- NCT00403897
- Testing
- Polyethylene glycol 3350 Na bicarbonate NaCl KCl
- Where
- Australia
- Volunteers
- 81 people
- Sponsor
- Norgine
Constipation
Safety and Tolerability of Oral Polyethylene Glycol (PEG 3350) Solution in Participants With Constipation (MK-8114-003)
The purpose of this study is to compare the safety and tolerability of oral ingestion of PEG 3350 solution concentrate to oral ingestion of a placebo solution concentrate, in participants with constipation.
- Trial name
- NCT01885104
- Testing
- Polyethylene Glycol (PEG 3350), Bisacodyl laxative tablets (rescue medication)
- Volunteers
- 65 people
- Sponsor
- Bayer
Constipation
CMTS4520-Assisted Washed Microbiota Transplantation for Chronic Constipation in Adults
This is a randomized controlled trial to explore the efficacy and safety of CMTS4520 (Dietary Fiber Probiotics) assisted washed microbiota transplantation for patients with chronic constipation.
- Trial name
- NCT06832176
- Testing
- CMTS4520 (dietary fiber probiotics)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Obstructive Defecation Syndrome, Chronic Constipation
Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)
The primary purpose of this study is to determine how effective and how durable STARR (stapled transanal rectal resection) surgery is in relieving symptoms of intractable constipation associated with obstructive defecation…
- Conditions
- Obstructive Defecation Syndrome, Chronic Constipation, Rectocele, Intussusception
- Trial name
- NCT00256984
- Testing
- Stapled Transanal Resection (STARR) with Transtar (PROXIMATE®) 33 mm Circular Stapler
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- Ethicon Endo-Surgery
Constipation - Functional
Transcutaneous Electrical Acupoint Stimulation (TEAS) for Chronic Constipation
Transcutaneous electrical acupoint stimulation (TEAS) is an emerging technology for non-invasive neuromodulation that has broad potential implications and warrants further study.
- Trial name
- NCT03243955
- Testing
- Verum TEAS
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Guillain-Barre Syndrome, Constipation
Gastrointestinal Transit Time in Patients With Guillain-Barré Syndrome
Constipation is a common condition among patients with Guillain-Barré Syndrome. It is believed, that the constipation is caused by autonomic neuropathy.
- Trial name
- NCT02459808
- Where
- Denmark
- Sponsor
- University of Aarhus