Clinical trials: Chronic Constipation, open to volunteers
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Chronic Idiopathic Constipation
This Study Aims to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties and Food Effect of IN-114199 in Healthy Participants
This study aims to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic properties and food effect of IN-114199 in healthy participants
- Trial name
- NCT06736912
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Constipation
Spinal Stabilization Exercise Training in Women With Chronic Constipation
This study was planned to investigate the effects of spinal stabilization exercise training on constipation symptom severity, quality of life, perception of recovery, and spinal stability in women with chronic constipation.
- Trial name
- Exercise (NCT06941103)
- Testing
- Spinal stabilization exercise training and recommendation, Recommendation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Özel Artı Disleksi Özel Eğitim ve Rehabilitasyon Merkezi
Constipation
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enema flushes.
- Trial name
- NCT05821309
- Testing
- PEG 3350, PEG-3350 with electrolytes, Glycerin
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Indiana University
Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC)
Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT).
- Conditions
- Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC), Crohn Disease (CD), Irritable Bowel Syndrome (IBS)
- Trial name
- NCT07261826
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Chen QiYi
Chronic Idiopathic Constipation (CIC)
A Study of Prucalopride in Breastfeeding Women With Constipation
Prucalopride is a medicine used to treat constipation. The main aim of the study is to measure prucalopride concentrations in breast milk.
- Trial name
- NCT04838522
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Takeda
Chronic Constipation, Slow Transit Constipation
MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders
The project presented here is a monocentric clinical study conducted by the Pediatric Surgery and Pediatrics departments of the University Hospital Erlangen.
- Conditions
- Chronic Constipation, Slow Transit Constipation, Intestinal Transit Disorder, Hirschsprungs Disease
- Trial name
- NCT06911749
- Testing
- MSOT with ICG, MRI
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr. med. Sonja Diez
Constipation
CMTS4520-Assisted Washed Microbiota Transplantation for Chronic Constipation in Adults
This is a randomized controlled trial to explore the efficacy and safety of CMTS4520 (Dietary Fiber Probiotics) assisted washed microbiota transplantation for patients with chronic constipation.
- Trial name
- NCT06832176
- Testing
- CMTS4520 (dietary fiber probiotics)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Constipation - Functional
Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial
The goal of this clinical trial is to evaluate the effect of dietary fibers in the treatment of functional constipation in women. It will also assess the potential side effects associated with fiber consumption.
- Trial name
- NCT07202481
- Testing
- Psyllium powder, Fructooligosaccharide
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of Minas Gerais
Chronic Idiopathic Constipation (CIC)
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
This is a 26-week, multi-center, randomized, double-blind, placebo-controlled study with a 4-week treatment-free Safety Follow-up period to assess the safety and efficacy of tenapanor (5 mg, 25mg, and 50 mg) in adult patients…
- Trial name
- NCT07382167
- Testing
- Tenapanor 5 mg BID, Tenapanor 25 mg BID, Tenapanor 50 mg BID
- Where
- 109 sites in United States
- Volunteers
- 692 people
- Sponsor
- Ardelyx
Constipation Chronic Idiopathic
MowOot and Trans-anal Irrigation fOr coNstipation
This prospective, open-labelled, longitudinal, controlled study aims to evaluate the suitability of Intermittent Colonic Exoperistalsis (ICE) treatment for adults with refractory chronic constipation who are awaiting trans-anal…
- Trial name
- MOTION (NCT06833684)
- Testing
- ICE Treatment, TAI Standard-of-Care Treatment
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- usMIMA S.L.
Constipation, Constipation - Functional
Soluble and Osmotic Fibre (SOLOS) Diet for Constipation
This research aims to study the dual effectiveness of incorporating soluble fibre and osmotic carbohydrates (SOLOS), with or without restricting fructans and GOS, and present novel findings in managing GI symptoms in patients…
- Conditions
- Constipation, Constipation - Functional, Constipation Chronic Idiopathic, Constipation Predominant Irritable Bowel Syndrome
- Trial name
- SOLOS (NCT07388589)
- Testing
- Diet
- Where
- Singapore
- Volunteers
- 180 people
- Sponsor
- Singapore Institute of Technology
Constipation - Functional, Fecal Microbiota Transplantation (FMT)
The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of Functional Constipation：a Pilot Study
Chronic constipation is a common gastrointestinal disease with a global prevalence of about 15%, significantly affecting daily life and quality of life.
- Conditions
- Constipation - Functional, Fecal Microbiota Transplantation (FMT), Chronic Constipation
- Trial name
- NCT07387952
- Testing
- FMT
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Peking Union Medical College Hospital
Refractory Constipation, Fecal Incontinence in Children
The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation
This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans…
- Trial name
- NCT07291661
- Testing
- High resolution anorectal manometry using a multiuse water perfused catheter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Constipation, Refractory
Long-term Evaluation of Percutaneous Endoscopic Caecostomy in Refractory Constipation
This observational monocentric study aims to evaluate the long-term effectiveness and tolerance of percutaneous endoscopic caecostomy (PEC) in patients with chronic refractory constipation.
- Trial name
- CONSTICAP 2 (NCT07160192)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Chronic Idiopathic Constipation, Irritable Bowel Syndrome (IBS-C)
"Efficacy and Safety of Linaclotide in Chronic Constipation"
Goal of this study is to evaluate the efficacy and safety of two different doses of Linaclotide in improving bowel function and patient-reported outcomes among Bangladeshi patients with chronic constipation for 8 weeks along with…
- Conditions
- Chronic Idiopathic Constipation, Irritable Bowel Syndrome (IBS-C), Chronic Constipation, CIC
- Trial name
- LIN-CC-BD (NCT07431957)
- Testing
- Linaclotide 72 micrograms, Linaclotide 145 micrograms
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Md Mehedi Shahriar
Constipation
Washed Microbiota Transplantation for Chronic Constipation in Adults
This is a single-center, randomized, double-blind, placebo-controlled, dose-exploring clinical study to explore the safety and efficacy of washed microbiota transplantation (WMT) for patients with chronic constipation.
- Trial name
- NCT06106685
- Testing
- High-dose washed microbiota suspension, Low-dose washed microbiota suspension
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Gastrointestinal Motility Disorders in Children, Hirschsprung Disease
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders.
- Conditions
- Gastrointestinal Motility Disorders in Children, Hirschsprung Disease, Constipation - Functional
- Trial name
- SMART-GUT (NCT07519915)
- Testing
- SNM/MRI/EMG
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Faecal Incontinence, Chronic Constipation
Outcome Research in Bowel Irrigation Techniques for the Treatment of Chronic Constipation and/or Faecal Incontinence
This clinical investigation is a post-market, exploratory, randomised, parallel, open-label investigation comparing two UKCA/CE-marked transanal irrigation products for the management of faecal incontinence and/or chronic…
- Trial name
- ORBIT-1 (NCT07473622)
- Testing
- Transanal irrigation
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Qufora A/S