Clinical trials: Chronic Coronary Disease
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congestive Heart Failure, Pulmonary Hypertension
Impact of Polymorphism on Pulmonary Pressure in Subjects With Pulmonary Hypertension of Different Cause
Pulmonary Hypertension (PH) is a disease that is characterized by vasoconstriction of small vessels of the lung. Many cases do have proliferation of endothelial cells within these vessels.
- Trial name
- NCT00893178
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- University of Leipzig
Coronary Artery Disease
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction.
- Trial name
- RGDHeart (NCT04871217)
- Testing
- 68Ga-NODAGA-RGD PET-imaging
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Heart Failure, Diabetes
DANHEART (H-HeFT and Met-HeFT)
The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin hydrochloride.
- Trial name
- DANHEART (NCT03514108)
- Testing
- Hydralazine Isosorbide Dinitrate, Metformin Hydrochloride
- Where
- 26 sites in Denmark
- Volunteers
- 1,100 people
- Sponsor
- Henrik Wiggers
Heart Failure
The Development of Tolerance to α1-Adrenoceptor Blockade With Chronic Carvedilol Treatment
There is now strong evidence from clinical trials that carvedilol therapy in heart failure is superior to therapy with metoprolol.
- Trial name
- NCT00585091
- Testing
- phenylephrine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block
Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block
Recent studies have shown that chronic stimulation of the right ventricle can cause deleterious effects to cardiac function and synchronicity.
- Conditions
- Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block, Postoperative Complete Heart Block
- Trial name
- NCT01477658
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Peripheral Artery Disease
REGistry of Long-term AnTithrombotic TherApy-1
To assess the rates of ischemic and hemorrhagic complications of long-term antithrombotic therapy in patients with chronic coronary syndromes
- Trial name
- REGATTA-1 (NCT04347200)
- Testing
- Antiplatelet Drug
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Heart Failure
Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure
Heart failure is a major health problem worldwide. Optimal treatment of this disabling and fatal condition may require functional characterization of the failed left ventricle (LV) and its interaction with the arterial system.
- Trial name
- VACHF (NCT01156207)
- Testing
- Aliskiren
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Total Occlusion of Coronary Artery
Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.
The objective of this study is to evaluate the safety and efficacy of the SoundBite™ Crossing System - Coronary (SCS-C) in a subject population with chronic coronary artery disease including Chronic Total Occlusion (CTO).
- Trial name
- ACTIVE (NCT03521804)
- Testing
- SoundBite™ Crossing System Active Wire 14
- Where
- 5 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- SoundBite Medical Solutions, Inc.
Coronary Occlusions
AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study
Chronically total occlusions (CTO) are difficult to treat and have high risk for restenosis. Although everolimus-eluting stents (EES) [(Xience, Abbott Vascular) or Promus (Boston Scientific)] are very promising for the treatment…
- Trial name
- ACE-CTO (NCT01012869)
- Testing
- everolimus-eluting stent
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- North Texas Veterans Healthcare System
Heart Failure, Acute Heart Failure
Protocol of Diuretics Use in Congestive Therapy in Heart Failure
The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.
- Conditions
- Heart Failure, Acute Heart Failure, Chronic Heart Failure
- Trial name
- ProDUCT-HF (NCT03892148)
- Testing
- Furosemide, Hydrochlorothiazide
- Where
- 9 sites in France
- Volunteers
- 299 people
- Sponsor
- University Hospital, Clermont-Ferrand
End-stage Renal Disease
Effects of Oral Sodium Bicarbonate Supplementation in Haemodialysis Patients (BicHD)
The purpose of the study is to investigate whether oral sodium bicarbonate supplementation to ensure a constant bicarbonate profile in haemodialysis patients will primarily lower predialysis potassium levels and secondary lead to…
- Trial name
- BicHD (NCT02692378)
- Testing
- sodium bicarbonate 500mg capsules
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College Healthcare NHS Trust
Atrial Fibrillation, Chronic Kidney Disease
The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function
This study is designed to investigate the role of lipids/lipoproteins as a potential cause for the harmful changes seen in fibrin clot properties with renal dysfunction and atrial fibrillation
- Trial name
- RALiC (NCT04043026)
- Testing
- Statin
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Liverpool
Heart Failure, COPD
Potentially Avoidable Hospitalisation in France
Potentially Avoidable Hospitalizations (Pah) Are Studied As An Indirect Measure Of Access To Primary Care And Of The Interface Between Primary And Secondary Care.
- Conditions
- Heart Failure, COPD, Diabetes
- Trial name
- HPE-LR (NCT02898155)
- Testing
- measure of access to primary care and of the Interface Between Primary ans Secondary Care
- Where
- France
- Volunteers
- 12,000 people
- Sponsor
- University Hospital, Montpellier
Heart Failure
Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure
A study to compare the efficacy and safety of eplerenone in Japanese chronic heart failure patients with placebo.
- Trial name
- J-EMPHASIS-HF (NCT01115855)
- Testing
- Eplerenone
- Where
- 54 sites in Japan
- Volunteers
- 221 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Asthma, Nasal Polyps
Asthma With Nasal Polyposis
Asthma is often associated with various comorbidities that may influence its clinical expression. Among those, chronic rhinosinusitis with nasal polyposis (CRSwNP) is observed in 5% of cases.
- Trial name
- NCT03694847
- Where
- Canada
- Volunteers
- 1,293 people
- Sponsor
- Louis-Philippe Boulet
Heart Failure
Intermittent Intravenous Levosimendan in Ambulatory Advanced Chronic Heart Failure Patients
The purpose of this study is to determine the safety and efficacy of intravenous administration of intermittent doses of levosimendan (infusions of 0,2 μg/kg/min, of levosimendan or placebo, without bolus, for 6 hours every 2…
- Trial name
- LION-HEART (NCT01536132)
- Testing
- Levosimendan
- Where
- 13 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Parc de Salut Mar
Cardiac Decompensation
Evaluate Heart Failure Patients With Specially Designed Patient Adherence and Monitoring Software on Standard Mobile Devices
This is planned as a feasibility study. The objective is to evaluate a specially designed patient adherence and monitoring software on standard mobile devices in remote monitoring of heart failure patients.
- Trial name
- REMOTE-HF-1 (NCT01430936)
- Where
- 5 sites in United States, India and 1 more
- Volunteers
- 51 people
- Sponsor
- Aventyn, Inc.
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