Clinical trials: Chronic Coronary Disease
Acute Coronary Syndrome, Chronic Coronary Artery Disease
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients
In this study, we evaluate the acute coronary syndrome patients to see if there is correlation between platelet activity, genetic polymorphism (CYP2C19 and ABCB1), serum adipokines level, and Clopidogrel responsiveness.
- Trial name
- NCT01255267
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Kidney Failure, Chronic, Coronary Artery Disease
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery…
- Trial name
- NCT00244530
- Testing
- Nifedipine
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Chronic Kidney Disease With and Without Hemodialysis
Patterns of Cardiac Arrhythmia in Patients With Chronic Kidney Disease
Cardiovascular diseases remain the primary leading cause of death in patients on maintenance hemodialysis accounting for nearly 41% of deaths.
- Trial name
- Arrhythmia (NCT07640919)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Heart Failure With Reduced Ejection Fraction
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of HJB647 at two different doses in participants with chronic stable heart failure with reduced or mildly reduced ejection fraction…
- Trial name
- NCT07465653
- Testing
- HJB647 low dose, HJB647 high dose
- Where
- 6 sites in United States, Canada
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Renal Insufficiency, Chronic
Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease
Heart failure (HF) is an epidemic and is a major burden on the US healthcare system. The most common cardiovascular endpoint is HF. Thus, novel interventions to prevent HF in chronic kidney disease (CKD) are highly desirable.
- Trial name
- NCT02791906
- Testing
- ISMN, Vitamin C
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease, Chronic Coronary Syndrome
Same-Day Discharge After Elective Transradial Percutaneous Coronary Intervention: A Pilot Randomized Trial
This single-center pilot randomized trial evaluated the safety and feasibility of same-day discharge (within 6 hours) compared with conventional overnight hospitalization (≥24 hours) in patients with chronic coronary artery…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Elective Percutaneous Coronary Intervention
- Trial name
- SDD-PROCAPE (NCT07830784)
- Testing
- same day discharge, Conventional Hospitalization
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- PAULO CASTRO CHERPAK
COPD, Congestive Heart Failure
Use of Non Invasive Hemodynamic Cardiovascular Monitoring to Evaluate Emergency Department Patients
This study is an observational prospective pilot trial that utilizes finger cuff non invasive hemodynamic monitoring (NexfinHD Monitor) to assess 4 different groups (CHF/COPD, Trauma, Sepsis, Stroke) of patients on arrival to the…
- Conditions
- COPD, Congestive Heart Failure, Trauma, Sepsis
- Trial name
- NCT00851214
- Testing
- NexfinHD Monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Covid19, SARS-CoV-2 Infection
Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients
Non-commercial depersonalized multi-centered registry study on analysis of chronic non-infectious diseases dynamics after SARS-CoV-2 infection in adults.
- Conditions
- Covid19, SARS-CoV-2 Infection, Pneumonia, Copd
- Trial name
- ACTIV (NCT04492384)
- Testing
- non-interventional
- Where
- Russia
- Volunteers
- 6,396 people
- Sponsor
- Eurasian Association of Therapists
Chronic Total Occlusion of Coronary Artery, Diabetes Mellitus, Type 2
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total…
- Trial name
- COLLECT (NCT06054126)
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Coronary Occlusion, Angioplasty, Balloon, Coronary
Functional Assessment-guided Angioplasty in Patients With Coronary Chronic Total Occlusion
The aim of this study is to investigate the role of functional evaluation for predicting clinical outcome in patients with coronary chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI), and to…
- Trial name
- FAGA-CTO (NCT03522038)
- Testing
- percutaneous coronary intervention
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay
Heart Failure
Effects of Acute and Chronic Empagliflozin Heart Failure
This is a 60-patient randomized, double-blind, placebo-controlled mechanistic study to understand the utility of empagliflozin in worsening heart failure (HF) patients with or without diabetes.
- Trial name
- EMPA HF (NCT05553938)
- Testing
- Empagliflozin 10 mg
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Heart Failure, Diabetes
Management of Diabetes With Metformin In Patients With Chronic Heart Failure
The Ahmanson-UCLA Cardiomyopathy Center is conducting a clinical research study that will assess the use of the medication metformin to improve quality of life, exercise capacity, and improved outcomes with patients that have…
- Trial name
- NCT01122316
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
End Stage Renal Disease, Left Ventricular Hypertrophy
Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study
Kidney patients on dialysis commonly die because of heart disease. One of the biggest problems in their hearts is that the muscle wall of the heart thickens. This makes it less efficient.
- Trial name
- Altered (NCT01951404)
- Testing
- Allopurinol
- Where
- 3 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Dundee
Chronic Kidney Disease, Congestive Heart Failure
Peritoneal Ultrafiltration to Treat Congestive Heart Failure
The purpose of this study is to determine whether the treatment of peritoneal ultrafiltration can improve survival and quality of life of refractory congestive heart failure with special accent on preserving residual renal…
- Trial name
- NCT02829450
- Testing
- peritoneal ultrafiltration
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Hyperglycemia, Chronic Heart Failure
The Effect of Liraglutide on Left Ventricular Function in Chronic Heart Failure Patients With and Without Type 2 Diabetes Mellitus
Type 2 diabetes (T2D) is a major risk factor of chronic heart failure (CHF). Glycemic control in patients with the combination of T2D and CHF is complicated and the currently available treatments have proven to be inadequate in…
- Trial name
- NCT01472640
- Testing
- liraglutide
- Where
- 4 sites in Denmark
- Volunteers
- 240 people
- Sponsor
- Flyvbjerg, Allan, DMSc
Dyspnea, Decompensated Heart Failure ; COPD Exacerbation
Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05352490
- Testing
- calculate LUS score
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
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