Clinical trials: Chronic Coronary Disease
Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease
EXCEL Clinical Trial
To establish the safety and efficacy of the commercially approved XIENCE Family Stent System (inclusive of XIENCE PRIME, XIENCE V, XIENCE Xpedition and XIENCE PRO [for use outside the United States [OUS] only]) in subjects with…
- Conditions
- Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease, Stent Thrombosis, Vascular Disease
- Trial name
- EXCEL (NCT01205776)
- Testing
- Percutaneous Coronary Intervention, CABG
- Where
- United States
- Volunteers
- 1,905 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Structural Heart Disease
Pressure-Volume Loop Assessment in Valvular Heart Disease
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD).
- Conditions
- Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- VHD-PV-loop (NCT07112391)
- Testing
- Observational Invasive Hemodynamic Assessment
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Heart Failure, Chronic Heart Failure
Continuum: Digital Health to Manage Heart Failure Outpatients
Heart failure (HF) is one of the leading causes of hospitalization and death worldwide. Remote patient monitoring and digital therapeutics could help reduce the consumption of care for these patients (hospitalizations, emergency…
- Trial name
- NCT05377190
- Testing
- Continuum HFC-IN, Standard of care for the follow-up, Continuum HFC-OUT
- Where
- Canada
- Volunteers
- 175 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Disease, Type II Diabetes Mellitus
Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease
Patients with coronary artery disease have an abnormal cardiac metabolism. The hypothesis of this study is that shifting cardiac metabolism from free fatty acids to glucose will improve myocardial ischemia
- Trial name
- NCT00282360
- Testing
- Trimetazidine
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Acute Coronary Syndrome, Chronic Coronary Syndrome
Identification of Molecular Mechanisms of Coronary Instability in Homogeneous Subsets of Patients With Acute Coronary Syndromes for the Implementation of Precision Medicine
To further improve the outcome of ACS it is strongly needed to identify new therapeutic targets. This is possible only by improving our knowledge of the multiple molecular mechanisms leading to coronary instability through…
- Trial name
- PRECISION (NCT05727982)
- Testing
- Venous blood samples, Biological samples analysis, Cardiology visit.
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Kidney Failure, Hemodialysis
SGLT2 Inhibition in Hemodialysis
Dapagliflozin will be compared with placebo to evaluate its effects on cardiac structure and safety in patients with kidney failure receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Hemodialysis, Diabetes Mellitus, Type 2, Chronic Kidney Disease
- Trial name
- DAPA-HD (NCT05179668)
- Testing
- Dapagliflozin 10 MG
- Where
- 9 sites in Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Coronary Heart Disease, Non ST-elevation Acute Coronary Syndromes
Residual Platelet Activity Despite Aspirin Utilization in Coronary Heart Disease
The purpose of this study is to compare the response to aspirin in the acute phase with the late phase of an acute coronary syndrome.
- Trial name
- NCT01820429
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Atrial Fibrillation Chronic
Comparing Pulmonary Vein Isolation to Pulmonary Vein Isolation + OPTIMA Ablation in Patients Undergoing Ablation for Atrial Fibrillation
Catheter ablation is an established cornerstone of therapy for patients with symptomatic atrial fibrillation (AF) who wish to avoid anti-arrhythmic drug therapy or for whom anti-arrhythmics have proven ineffective.
- Trial name
- OPTIMA (NCT04101539)
- Testing
- OPTIMA-guided catheter ablation, Standard PVI
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Chronic Heart Failure, Cardiac Cachexia
Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia
The purpose of this study was to determine the effects of a high caloric drink on weight and several other clinical markers including quality of life in patients with unintentional weight loss (cachexia) due to chronic heart…
- Trial name
- NCT00654719
- Testing
- NutriDrink
- Where
- 2 sites in Germany, Poland
- Volunteers
- 29 people
- Sponsor
- National Heart and Lung Institute
Coronary Artery Disease
Cell Therapy for Coronary Heart Disease
Impaired contractile function after a heart attack and due to coronary heart disease is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy.
- Trial name
- NCT00289822
- Testing
- intracoronary infusion of progenitor cells
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Myocardial Infarction, Outcome
Acute and Chronic Protective Effects of Peri-interventional Administration of Levosimendan in ST Elevation Myocardial Infarctions
In the proposed project the investigators want to assess whether the approach of the post-conditioning by Levosimendan in patients with acute STEMI is safe and reproducible, can be used with a positive influence on the outcomes…
- Trial name
- NCT03022877
- Testing
- Levosimendan
- Sponsor
- RWTH Aachen University
Kidney Failure, Chronic
Left Ventricular Hypertrophy and Spironolactone in End Stage Renal Disease
The hypothesis of this trial is to assess the effect of spironolactone on heart size and mass
- Trial name
- NCT00548912
- Testing
- Spironolactone
- Where
- United States
- Sponsor
- Dawnmarie DeFazio
SGLT2 Inhibitiors Remodeling Effect, Chronic Heart Disease
Effect of Sodium Glucose Cotransporter 2 Inhibitiors on Left Ventricular Remodeling Among Diabetic and Non Diabetic Patients With Chronic Heart Failure
To evaluate the efficacy of SGLT2 inhibitors on left ventricular global longitudinal strain and diastology parameters among diabetic and non-diabetic patients with chronic heart failure
- Trial name
- NCT06137430
- Testing
- Sodium-glucose cotransporter 2 inhibitor
- Volunteers
- 98 people
- Sponsor
- Assiut University
Heart Failure, Cardiomyopathies
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure
The purpose of this study is to determine whether galectin-3 binding protein plasma levels can predict adverse cardiovascular events in patients with coronary artery disease and/or heart failure.
- Conditions
- Heart Failure, Cardiomyopathies, Coronary Artery Disease
- Trial name
- GALACTIC (NCT01210157)
- Where
- Germany
- Volunteers
- 373 people
- Sponsor
- Heidelberg University
Rehabilitation With CHF; NYHA Class I or II
Baduanjin Exercise for Patients With Chronic Heart Failure on Phase II Cardiac Rehabilitation
Chronic heart failure (CHF) is the end stage of various kinds of cardiovascular diseases with high mortality. After a long period of medical treatment or surgical treatment, patients suffered great pain physically and mentally.
- Trial name
- BEPCR (NCT03229681)
- Testing
- Baduanjin exercise, Routine rehabilitation group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Rheumatic Heart Disease
Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge
Rhumatic heart disease patients with mitral regurge untile know had adibat for timming of surgical interferance our study aim to solve this problme using a new technic in echocardiography called speckle tracking which is more…
- Trial name
- NCT03156972
- Testing
- Replacment of mitral valve
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mohammed mahmoud mohammed othman
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II
As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT05050877
- Where
- China
- Volunteers
- 184,855 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Restenosis
Clinical Evaluation of Patients With Everolimus-eluting Stent Xience V® Implanted in the Treatment of Restenosis in Non-coated Metallic Stent (BMS In-stent Restenosis) During a 2 Year Clinical Follow-up Period
Interventional, prospective, non-randomized, non-comparative, open and multicentric study of patients with everolimus-eluting stent " Xience V® " implanted in the treatment of restenosis in non-coated metallic stent (BMS in-stent…
- Trial name
- XERES (NCT00882219)
- Testing
- Xience V®
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Abbott Medical Devices
End Stage Renal Disease, Chronic Kidney Disease
Risk Stratification in End Stage Renal Disease (ESRD) - ISAR Study
The purpose of this study is to evaluate the use of non-invasive markers of the autonomic function and micro- and macrocirculation to predict mortality and cardiovascular end points in end-stage renal disease patients.
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Cardiovascular Event, Sudden Cardiac Death
- Trial name
- ISAR (NCT01152892)
- Where
- 17 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Emphysema, Pulmonary Disease, Chronic Obstructive
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a lung disease that is primarily caused by cigarette smoking. The breakdown of elastin, a protein found in the lungs, can cause lung damage and may contribute to the development of…
- Trial name
- NCT00725309
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Washington University School of Medicine
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