Clinical trials: Chronic Coronary Disease
Chronic Heart Failure
Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure
The primary objective of this study is to determine whether transendocardial delivery of allogeneic human bone marrow-derived mesenchymal precursor cells (MPCs [rexlemestrocel-L]) is effective in the treatment of chronic heart…
- Trial name
- DREAM HF-1 (NCT02032004)
- Testing
- Rexlemestrocel-L
- Where
- 59 sites in United States, Canada
- Volunteers
- 565 people
- Sponsor
- Mesoblast, Inc.
COPD (Chronic Obstructive Pulmonary Disease), Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)
Heart Failure With Preserved Ejection Fraction in Patients With Сhronic Obstructive Pulmonary Disease: Clinical Course and Prognosis
Study aim is comparison of heart failire with preserved ejection fraction (HFpEF) detection rate in patients with Сhronic Obstructive Pulmonary Disease (COPD) and the clinical course and prognosis in patients with COPD depending…
- Trial name
- HIPSTER (NCT07375433)
- Testing
- Echocardiography, Spirometry, Body plethysmography
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure
NoYA RAISE Trial II (Radiofrequency Ablation-Based Interatrial Shunt for Heart Failure)
A Prospective, Multiple Center, and Objective Performance Criteria Study to Evaluate the NoYA™ Radiofrequency Interatrial Shunt System manufactured by NoYA Medtech (Hangzhou) Co., Ltd.
- Trial name
- NCT05375110
- Testing
- NoYA™ Radiofrequency Interatrial Shunt System
- Where
- 31 sites in China
- Volunteers
- 120 people
- Sponsor
- Hangzhou NOYA MedTech Co. Ltm.
Coronary Artery Disease, Calcified Coronary Artery Disease
Coronary Laser in Undilatable or Uncrossable Lesions
This will be an investigator-initiated, multicentre, single-arm, open-label, prospective observational study. Patients with indication for PCI and undilatable (non-compliant balloon dilatation <80% at burst pressure) or…
- Conditions
- Coronary Artery Disease, Calcified Coronary Artery Disease, In Stent Restenosis, Chronic Total Occlusion (CTO)
- Trial name
- LUDICO (NCT07206082)
- Testing
- Laser atherectomy
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Hospital Universitario La Paz
Chronic Stable Angina
Yinxingmihuan Oral Solution in Treatment of Chest Pain After PCI
A prospective, multi-center, double-blind, randomized, placebo-controlled trial is conducted to evaluate the efficacy and safety of Yinxingmihuan oral solution in the treatment of chest pain after percutaneous coronary…
- Trial name
- NCT06224582
- Testing
- Yinxingmihuan oral solution
- Where
- China
- Volunteers
- 320 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Heart Failure
A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
A placebo controlled, double-blind and randomized study to assess different doses of a new drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the well-being of patients with acute…
- Trial name
- COMPOSE 2 (NCT01067859)
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 30 sites in United States, Argentina and 7 more
- Volunteers
- 5 people
- Sponsor
- Bayer
Heart Disease, Chronic Disease
Real-World Evaluation of a Digitally Enabled Cardiac Rehabilitation Program
After a heart event or procedure, patients are encouraged to participate in a cardiac rehabilitation (CR) program to improve their health and reduce the risk of future problems.
- Conditions
- Heart Disease, Chronic Disease, Cardiovascular Disease Prevention
- Trial name
- NCT06813482
- Testing
- Digitally enabled cardiac rehabilitation, F2F-CR, Usual Care Group
- Where
- Australia
- Volunteers
- 172 people
- Sponsor
- Baker Heart and Diabetes Institute
Coronary Artery Disease, Myocardial Ischaemia
Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy
The overall purpose of ACCURATE II trial is to compare the clinical outcomes of CT-derived FFR guided strategy versus medical therapy in patients with chronic coronary syndrome.
- Trial name
- ACCURATE II (NCT05824520)
- Testing
- ITS plus OMT, OMT
- Where
- China
- Volunteers
- 1,066 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer, Congestive Heart Failure
Expanding Access to Home-Based Palliative Care
This study will test the effectiveness of integrating an evidence-based model of home-based palliative (HBPC) within primary care clinics on patient and caregiver outcomes.
- Conditions
- Cancer, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT03128060
- Testing
- Home-based palliative care, Enhanced usual care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Southern California
End Stage Chronic Renal Failure, Congestive Heart Failure (CHF)
The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are…
- Conditions
- End Stage Chronic Renal Failure, Congestive Heart Failure (CHF), Intravascular Congestion, Fluid Overload
- Trial name
- FILTRATE (NCT07705269)
- Testing
- High-rate ultrafiltration, Standard fluid removal
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Chronic Heart Failure With Low Ejection Fraction
ContriBution of Digital RemOte MoniToring to IMPROVing The Effectiveness of Treatment in Patients With Chronic Heart Failure With Low Ejection Fraction
BOT-IMPROVE-HF is a two-center, parallel group study designed to evaluate the efficacy of up-titration of heart failure treatment using digital remote monitoring after hospitalization due to heart failure decompensation.
- Trial name
- BOT-IMPROVE-HF (NCT06304753)
- Testing
- Telebot
- Where
- 2 sites in Russia
- Volunteers
- 66 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Stable Angina, PTCA
Myocardial Damage and Music Study
MYDA-MUSIC study is a randomized, double blind (operator and analyst) study performed in San Filippo Neri Hospital, Roma, Italy and in Di Venere Hospital, Bari, Italy. The planned study duration is 12 months.
- Trial name
- MYDA-MUSIC (NCT03507361)
- Testing
- HRV-BASED MUSIC
- Where
- Italy
- Volunteers
- 443 people
- Sponsor
- San Filippo Neri General Hospital
Chronic Obstructive Lung Disease
The Pulmonary Protection Trial
The purpose of this study is to investigate whether patients with a preoperative reduced pulmonary function have a better preserved oxygenation capacity after open heart surgery, using either pulmonary perfusion or pulmoplegia…
- Trial name
- NCT01614951
- Testing
- Perfusion of the lungs, HTK Custodiol, Standard ECC
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Atrial Fibrillation, Medication Adherence
Determination of Rates and Reasons for Non-Adherence to Anti-Arrhythmic Therapy for Atrial Fibrillation
The purpose of this study is to determine if follow-up by a pharmacist over the telephone improves adherence and short term clinical outcomes in the patient with atrial fibrillation prescribed an oral anti-arrhythmic medication.
- Trial name
- NCT01513031
- Testing
- Education and telephone follow-up
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Creighton University
Heart Failure
Assessment of adherenCe tO Medical theraРy and Its infLuence on Long-term Outcomes In pAtieNts With Heart Failure
The aim of this prospective cohort study is to assess the adherenсe to medical therapy and its influence on long-term outcomes in patients with chronic heart failure in the outpatient registry
- Trial name
- COMPLIANCE (NCT04262583)
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- National Research Center for Preventive Medicine
Kidney Failure, Acute, Oxidative Stress Induction
N-acetylcysteine to Prevent Renal Failure
The purpose of this study is to determine the possible effect nephroprotective of N-acetylcysteine in patients with chronic kidney disease undergoing elective coronary artery bypass grafting by serial evaluation of renal function…
- Trial name
- NCT01359722
- Testing
- N-acetylcysteine, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto do Coracao
Congestive Heart Failure
EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan
The purpose of this study is to compare the effectiveness of tolvaptan or placebo in adults with worsening congestive heart failure (CHF).
- Trial name
- NCT00071331
- Testing
- Tolvaptan
- Where
- 378 sites in United States, Argentina and 16 more
- Volunteers
- 3,600 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Coronary Artery Disease
DISsection RE-entry Evaluation With Absorb Bioresorbable Vascular Scaffolds in CTO.
Percutaneous Coronary Intervention (PCI) is increasingly effective to treat Chronic Total Occlusion (CTO) lesions in coronary arteries.
- Trial name
- DISCRETE-CTO (NCT02936011)
- Testing
- CTO PCI using Absorb Bioresorbable Vascular Scaffolds
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Belfast Health and Social Care Trust
Chronic Kidney Disease, Pediatric
The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be…
- Conditions
- Chronic Kidney Disease, Pediatric, Cardiovascular Disease
- Trial name
- 4C (NCT01046448)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 650 people
- Sponsor
- Heidelberg University