Clinical trials: Chronic Coronary Disease
Pleural Effusion, Pleurodesis
Betadine Pleurodesis Via Tunneled Pleural Catheters
The purpose of this study is to determine whether betadine (povidone-iodine) instillation during routine indwelling Tunneled Pleural Catheter (TPC) placement is efficacious in promoting pleurodesis and thus reducing the time to…
- Conditions
- Pleural Effusion, Pleurodesis, Malignant Pleural Effusion, Pleural Effusion Due to Congestive Heart Failure
- Trial name
- NCT02975921
- Testing
- Povidone-Iodine
- Sponsor
- Yale University
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Kidney Diseases, Kidney Dysfunction
Music Therapy Intervention During Kidney Biopsy.
Kidney biopsy (KB) is an invasive procedure that is very useful in diagnosing kidney disease in both the native kidney and the transplanted kidney. Patients undergo KB can feel anxiety and pain.
- Conditions
- Kidney Diseases, Kidney Dysfunction, Kidney Disease, Chronic
- Trial name
- MTI-KB (NCT05119816)
- Testing
- music therapy intervention
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heart Failure, Ageing
Leipzig Exercise Intervention in Chronic Heart Failure and Aging
In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-term training interventions…
- Trial name
- LEICA (NCT00176319)
- Testing
- Aerobic endurance exercise training (ergometer)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Refractory Angina, Chronic Stable Angina
Coronary Arteriogenetic Heparinized Exercise
This study evaluates the addition of heparin to a 2-week cycle of physical rehabilitation in the treatment of refractory angina.
- Trial name
- CARHEXA (NCT03350737)
- Testing
- Physical rehabilitation, Heparin
- Where
- Serbia
- Volunteers
- 32 people
- Sponsor
- Clinical Centre of Serbia
Chronic Kidney Disease, Cardiovascular Morbidity
Chemoreflex Sensitivity in Chronic Kidney Disease
Cardiovascular morbidity and mortality are markedly increased in chronic kidney disease (CKD) and may be explained in part by sympathetic hyperactivity.
- Trial name
- NCT00794872
- Testing
- blood sampling
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Chronic Kidney Disease, Chronic Heart Failure
Intravenous Iron in Patients With Severe Chronic Heart Failure and Chronic Kidney Disease
Recently, growing body of evidence support the finding that anemia frequently occurs in patients with chronic heart failure (CHF).
- Conditions
- Chronic Kidney Disease, Chronic Heart Failure, Anemia
- Trial name
- NCT00384657
- Testing
- iron sucrose
- Where
- 2 sites in Romania
- Sponsor
- Anemia Working Group Romania
Heart Failure, Heart Failure NYHA Class III
Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
The Narrative Intervention for Chronic Illness-Heart Failure (NICI-HF) offers an asynchronous interactive text behavioral health intervention to advance behavioral health equity by facilitating access to care for people adjusting…
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NICI-HF (NCT06097481)
- Testing
- Narrative Intervention for Chronic Illness-Heart Failure, Attention Control
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Coronary Occlusion
Observational Study Evaluating the Management of Chronic Coronary Occlusions In France
Data from the literature on the management of Chronic Coronary Occlusions (CTO) in France highlight a lack of epidemiological data on these patients at the national level.
- Trial name
- ENCOCHE (NCT04281212)
- Where
- France
- Volunteers
- 1,303 people
- Sponsor
- French Cardiology Society
Central Sleep Apnea, Heart Failure
French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS, AirCurve 10CS): Predictive Factors of Poor Compliance (FACE)
The purpose of this study is to determine the predictive factors of poor compliance to sleep disordered breathing therapy in chronic heart failure patients treated for central sleep apnea.
- Trial name
- FACE (NCT02356367)
- Testing
- telemonitoring
- Where
- 3 sites in France
- Sponsor
- ResMed
Ventricular Tachycardia, Ventricular Arrythmia
Preventive VT Substrate Ablation in Ischemic Heart Disease
The investigators hypothesize that preventive VT substrate ablation in patients with chronic ICM, previously selected based on imaging criteria (BZC mass) for their likely high arrhythmic risk, is safe and effective in preventing…
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- PREVENT-VT (NCT04675073)
- Testing
- Ventricular tachycardia substrate-based radiofrequency ablation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Centro Medico Teknon
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the…
- Conditions
- Type 2 Diabetes Mellitus, Chronic Kidney Disease, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT02251431
- Testing
- BYDUREON
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Microbial Colonization, Coronary Artery Disease
Effect of Acute Cardiovascular Disease on Microbiome
Atherosclerotic diseases such as coronary artery disease (CAD) and peripheral arterial disease (PAD) are the leading cause of morbidity and mortality in the industrialized world.
- Conditions
- Microbial Colonization, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- MIAMI (NCT05456802)
- Testing
- Standard of care treatment
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Essen
Acute Kidney Disease, Chronic Kidney Disease
Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease
The protective nitric oxide (NO) effects are mediated by selective pulmonary vasodilation and improvement of arterial oxygenation in hypoxemic patients by reducing intrapulmonary shunting and improving ventilation-perfusion…
- Conditions
- Acute Kidney Disease, Chronic Kidney Disease, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- DEFENDER (NCT05757557)
- Testing
- 80-ppm NO
- Where
- Russia
- Volunteers
- 136 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Atrial Fibrillation, Chronic Kidney Disease
Warfarin Versus Aspirin in Patients With Atrial Fibrillation and Chronic Kidney Disease
In this study, the investigators examine whether aspirin or warfarin is useful for atrial fibrillation patients with chronic kidney disease.
- Trial name
- NCT01668901
- Testing
- warfarin, Aspirin
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Diabetes, Chronic Kidney Insufficiency
Prevention of Contrast Induced Nephropathy by Erythropoietin
This ia a prospective, randomized, double blind, placebo controlled trial. patients schedule for primary PCI or elective PCI will randomly allocated to receive either a single dose of EPO (Recormon, Roche, Epoetin beta) or saline…
- Trial name
- NCT01364402
- Testing
- Epoetin beta, Saline 0.9%
- Where
- Israel
- Volunteers
- 142 people
- Sponsor
- Western Galilee Hospital-Nahariya
Angina Pectoris
Phase II Multi-Center Study of T89 to Treat Chronic Stable Angina
The purpose of this study is to determine the anti-angina effect and dose response of T89, a 2-herb botanical drug product, in patients with chronic stable angina pectoris in the United States.
- Trial name
- T89 phase 2 (NCT00797953)
- Testing
- T89
- Where
- 15 sites in United States
- Volunteers
- 124 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France
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