Clinical trials: Chronic Cough, open to volunteers
Chronic Cough (CC)
Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents.
- Trial name
- APEC (NCT06600646)
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Chronic Cough, Video-assisted Thoracoscopic Surgery (VATS)
A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery.
This study aims to systematically evaluate the effects of different anesthesia methods on postoperative chronic cough in lung cancer patients undergoing video-assisted thoracoscopic lung resection (VATS), and to clarify the…
- Trial name
- Chronic cough (NCT07190664)
- Testing
- Patients were randomly grouped
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Refractory Chronic Cough
The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC)
The purpose of this study is to evaluate the efficacy and safety of Nalbuphine ER Extended-release tablets for the treatment of participants with RCC.
- Trial name
- LAKE (NCT07671924)
- Testing
- NAL ER
- Where
- 21 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Trevi Therapeutics
Chronic Cough
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
This study is being done in order to understand what causes people to have a chronic cough, which is defined as a cough lasting for more than 8 weeks.
- Trial name
- NCT06286163
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Cough (CC)
China Chronic Cough Registry: a Multicenter, Prospective, Observational Study
The aim is to establish a national clinical database and biobanks for chronic coughers. Through real-world chronic cough case registry and follow-up studies, we will explore the clinical phenotypes and molecular subtypes of…
- Trial name
- NCT06862362
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets
The primary purpose is to evaluate the safety and efficacy of NAL ER for the treatment of chronic cough in participants with Idiopathic Pulmonary Fibrosis (IPF).
- Trial name
- OCEAN-1 (NCT07671911)
- Testing
- NAL ER
- Where
- 22 sites in United States
- Volunteers
- 306 people
- Sponsor
- Trevi Therapeutics
Chronic Cough
Finnish Children´s Protracted Cough
Prolonged cough lasting more than four weeks is common in children, but the best treatment is often unclear when no underlying disease can be found.
- Trial name
- FINNCHICO (NCT07582549)
- Testing
- Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Monitoring Coughs for the Early Detection of Worsening COPD
This study is for adults with COPD. Flare-ups of COPD, also known as exacerbations, can be serious and lead to hospital stays. The purpose of this research is to see if continuously and automatically monitoring a person's coughs…
- Trial name
- Hyfe-EPOC (NCT07212439)
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Refractory Chronic Cough
A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
- Trial name
- CALM-2 (NCT07650084)
- Testing
- BLU-5937
- Where
- 38 sites in China
- Volunteers
- 75 people
- Sponsor
- GlaxoSmithKline
Chronic Cough
Efficacy of Behavioral Therapy for Chronic Refractory Cough
Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life.
- Trial name
- NCT07488598
- Testing
- Behavioral Therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Chronic Cough (CC)
Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in Children
Chronic cough is a common and burdensome condition in children, with complex and overlapping etiologies that often lead to delayed diagnosis, misdiagnosis, and inappropriate treatment.
- Trial name
- NCT07306637
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Children's Medical Center
Protracted Bacterial Bronchitis
Antibiotics, Microbiology and Immunology in Children With Chronic Wet Cough - the AMIC Study
The AMIC study is a double-blind, placebo-controlled, multicenter, nationwide, randomized controlled academic pharmaceutical trial.
- Trial name
- AMIC (NCT06020716)
- Testing
- Amoxicillin-Clavulanate 400 Mg-57 Mg/5 mL Oral Powder for Reconstitution
- Where
- 7 sites in Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Interstitial Lung Disease
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with interstitial lung disease (ILD)-related cough.
- Trial name
- MACS-2 (NCT05120934)
- Testing
- Amitriptyline 25 MG, Amitriptyline 50 MG, Duloxetine 30 MG
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Upper-Airway Cough Syndrome
Laryngeal Cryotherapy for Refractory Neurogenic Cough
This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure
- Trial name
- NCT05665244
- Testing
- Laryngeal cryotherapy, Cryoprobe
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Cough
An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough
Cough has previously been described by the type of cough you have ie such as wet, dry, and chesty, and also by its features such as how often you are coughing its,intensity, and severity, but never has the varying patterns of…
- Trial name
- NCT06376448
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Cough
Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough
This study is a prospective, single-center, single-arm pilot trial. The primary research question is whether brief, breath control-focused Acceptance and Commitment Therapy (ACT) is feasible, acceptable, and safe in adults with…
- Trial name
- FAST-COUGH (NCT07566117)
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Refractory Chronic Cough, Unexplained Chronic Cough
Cough Management Wellness App for Refractory or Unexplained Chronic Cough
The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough.
- Conditions
- Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity
- Trial name
- NCT07070895
- Testing
- Cough Management, CoughMonitor Suite
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hyfe Inc
Refractory Chronic Cough
A Phase 2 Study of HW091077 in Participants With Refractory Chronic Cough Or Unexplained Chronic Cough (RCC/UCC).
This is a randomized, multicenter, double-blind, placebo-controlled, parallel-designed phase 2 clinical trial to evaluate the efficacy, safety and pharmacokinetic (PK) characteristics of HW091077 in Chinese adult subjects with…
- Trial name
- NCT07483489
- Testing
- HW091077
- Volunteers
- 180 people
- Sponsor
- Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.