Clinical trials: Chronic Disease (Physical)
Terminal Diseases, Terminal Care
Medical Assistance in Dying Requests in Pain Clinic
Terminally ill patients often suffer existentially. Terminally ill patients with existential pain may request medical aid in dying.
- Conditions
- Terminal Diseases, Terminal Care, Chronic Pain, Disability or Chronic Disease Leading to Disablement
- Trial name
- MAiD (NCT06802562)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Salem Anaesthesia Pain Clinic
Obesity, Chronic Pain
Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Chronic Pain, Abdominal Pain
- Trial name
- Chron Pain LSG (NCT06686875)
- Testing
- Questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Non-specific Chronic Neck Pain
Comparison Between Two Physical Therapy Treatments in Patients With Nonspecific Chronic Neck Pain
Introduction: Non-specific chronic neck pain is a very prevalent condition in the population ranging from 45% to 54%. Several conservative treatments have been shown to be effective and are currently used in clinical practice.
- Trial name
- NCT04695730
- Testing
- Active physical therapy (including both pain education and home exercises), Active physical therapy plus manual therapy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Bologna
Endstage Renal Disease
Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients
Patients undergoing chronic dialysis are at a substantially increased risk of cardiac death. The reasons for this excess cardiovascular mortality are only partly understood.
- Trial name
- RACE (NCT02207153)
- Where
- Switzerland
- Volunteers
- 217 people
- Sponsor
- University Hospital, Basel, Switzerland
Myelodysplastic Syndromes, Leukemia Myeloid Acute
A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric…
- Conditions
- Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell
- Trial name
- NCT02842229
- Where
- 15 sites in Spain
- Volunteers
- 117 people
- Sponsor
- Celgene
Lymphoma
Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells and slow the growth of non-Hodgkin's lymphoma.
- Trial name
- NCT00003639
- Testing
- recombinant interferon alfa, chlorambucil, dexamethasone
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Scotland and Newcastle Lymphoma Group
Endometriosis, Vulvodynia
An Investigation of Nomothetic Versus Idiographic Assessment in Chronic Pain
Endometriosis, vulvodynia, and fibromyalgia are chronic pain conditions that cause great suffering. Despite the significant prevalence of all three conditions, they are receiving relatively little attention in psychological…
- Conditions
- Endometriosis, Vulvodynia, Fibromyalgia
- Trial name
- NCT05518630
- Testing
- Nomothetic Versus Idiographic Assessment in Chronic Pain
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Chronic Spinal Cord Injury
LIFT Home Study of Non-Invasive ARC Therapy for Spinal Cord Injury
The LIFT Home Study is an observational, single-arm study designed to assess the safety of non-invasive electrical spinal stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in…
- Trial name
- NCT05284201
- Testing
- LIFT System
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- ONWARD Medical, Inc.
Pelvic Pain, Endometriosis
Personalized Exercise Recommendations for Chronic Pelvic Pain Using Reinforcement Learning
WorkoutCPP is a pilot study evaluating the feasibility of a personalized exercise recommendation system for individuals with chronic pelvic pain disorders (CPPDs).
- Conditions
- Pelvic Pain, Endometriosis, Chronic Pelvic Pain
- Trial name
- WorkoutCPP (NCT07810218)
- Testing
- Reinforcement Learning (RL)-Based Personalized Exercise Recommendations, Generic Exercise Recommendation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Heart Failure
Cardiac Magnetic Resonance Imaging Guided Left Ventricular Lead Placement
Heart failure is a common, costly, disabling and potentially lethal condition. Despite well recognised and proven drug therapies, many patients remain breathless on exertion.
- Trial name
- NCT01417624
- Testing
- CMR Guidance in terms of guiding LV lead implantation
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Hepatitis C, Chronic
An Observational Study To Assess Liver Fibrosis Stages in Patients With Chronic Hepatitis C Infection
This multi-center, prospective observational study will evaluate the correlation of liver biopsy and transient elastography in liver fibrosis assessment in patients with chronic hepatitis C. Data will be collected for 96 weeks.
- Trial name
- NCT01671046
- Where
- 10 sites in Brazil
- Volunteers
- 123 people
- Sponsor
- Hoffmann-La Roche
Heart Failure
Assessment of Physical Activity and Cardiovascular Outcomes in Patients With Chronic Heart Failure
SOPHIE is a prospective, multicentre, observational cohort study aiming to enrol 2,000 CHF patients. Baseline assessments include validated PA questionnaires (GPAQ, IPAQ, KCCQ) and seven-day step counts from commercially…
- Trial name
- SOPHIE (NCT07460531)
- Where
- 2 sites in Germany, Italy
- Volunteers
- 2,000 people
- Sponsor
- LMU Klinikum
Pulmonary Disease, Chronic Obstructive
OTIVACTO Spain Non Interventional Study
This is a self-controlled study design enrolling consented COPD patients who will be treated with Spiolto® Respimat® according to the approved SmPC.
- Trial name
- NCT02927795
- Where
- 79 sites in Spain
- Volunteers
- 257 people
- Sponsor
- Boehringer Ingelheim
Renal Injury, Acute
Acute Kidney Injury : Long-term Renal and Cardiovascular Prognosis and Biomarker-based Risk Assessment
Patients who develop severe acute kidney injury (AKI) in intensive care remain at increased long-term risk of mortality, major cardiovascular events, and chronic renal complications, including prolonged dependence on renal…
- Trial name
- AKIRA (NCT07596407)
- Where
- France
- Volunteers
- 412 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Diseases, Cardiovascular Risk Factors
Cardiovascular Risk Factors and Physical Activity in Chronic Kidney Patients on Peritoneal Dialysis
The objective of this study was to examine the association between cardiovascular risk factors and physical activity parameters in patients with chronic kidney disease who are treated with peritoneal dialysis.
- Conditions
- Chronic Kidney Diseases, Cardiovascular Risk Factors, Arterial Stiffness, Physical Activity
- Trial name
- NCT07041554
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Dokuz Eylul University
Chronic Kidney Diseases, Iron-Deficiency Anemia
Endoscopy in CKD With Iron Deficiency Anemia
Iron deficiency anemia is very common in CKD patients. Data about gastrointestinal lesions in Arab patients are insufficient.
- Trial name
- NCT05240677
- Testing
- Upper GIT endoscopy
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Walid Ahmed Ragab Abdelhamid
Chronic Lymphocytic Leukemia
Exercise As Intervention in Chronic Lymphocytic Leukemia
PURPOSE: The purpose of the study is to determine the effects of 16-weeks of exercise training, as measured by aerobic capacity, strength and physical function, and body composition, in patients with Chronic Lymphocytic Leukemia…
- Trial name
- ADRENALINE (NCT06396611)
- Testing
- Exercise Training as Intervention
- Where
- Portugal
- Volunteers
- 11 people
- Sponsor
- Universidade do Porto
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
COPD Patients and Patients Recovering From COVID19
Increasing Physical Activity in COPD Through Rhythmically Enhanced Music
The VA cares for nearly one million Veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social…
- Trial name
- NCT03655028
- Testing
- rhythmically auditory stimulation enhanced music, control
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
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