Clinical trials: Chronic Disease (Physical)
Psoriasis
A Phase 2b Study of the Efficacy, Safety, and Tolerability of M1095 (Sonelokimab) in Subjects With Moderate to Severe Psoriasis
This is a multi-center phase 2b study in subjects with moderate to severe chronic plaque-type psoriasis. Approximately 300 subjects will be enrolled at approximately 60 investigator sites in North America and Europe.
- Trial name
- NCT03384745
- Testing
- M1095 (Sonelokimab), Secukinumab
- Where
- 60 sites in United States, Bulgaria and 5 more
- Volunteers
- 313 people
- Sponsor
- Bond Avillion 2 Development LP
Covid19, Post-acute Covid-19 Syndrome
Physical Training in Patients With POTS After Covid-19
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Covid19, Post-acute Covid-19 Syndrome, Postural Orthostatic Tachycardia Syndrome
- Trial name
- POTS-ReCOV (NCT05094622)
- Testing
- Physical exercise program
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Chronic Myeloid Leukemia (CML)
Cardiovascular Assessment of Ponatinib as Third Line Treatment in Chronic Phase Chronic Myeloid Leukemia
This study will address the therapeutic activity and the safety/biological profile of Ponatinib when used as third line therapy of Chronic Myeloid Leukemia in Chronic Phase after the only two TKIs known for their cardiovascular…
- Trial name
- CarPAs (NCT04709731)
- Testing
- Ponatinib 15mg QD, Ponatinib 30mg QD
- Where
- 13 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Associazione Italiana Pazienti Leucemia Mieloide Cronica
Small/Large Bowel
PillCam SB3 Capsule- Feasibility Study
Study hypothesis: PillCam SB3 is a new capsule designed to provide an improved image quality, and improved SB and duodenum tissue coverage due to Adaptive Frame Rate (AFR) of 2-6 fps, which will create more images for evaluation…
- Trial name
- NCT01433042
- Testing
- capsule endoscopy
- Where
- 4 sites in Israel, Romania and 2 more
- Volunteers
- 225 people
- Sponsor
- Medtronic - MITG
Frailty, Pain, Chronic
Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.
This research is being done to better understand the impact of the use of a specific physical activity training program (GH Method) in dialysis/kidney disease patients.
- Conditions
- Frailty, Pain, Chronic, Dialysis; Complications, Kidney Diseases
- Trial name
- NCT06374537
- Testing
- Muscle Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Chronic Renal Failure, Hemodialysis Treatment, Protein-energy Wasting
Effect of Intradialytic Physical ACTIvity in Addition to a NUTritional Support on Protein Energy Wasting and Physical Functioning in Chronic Hemodialysis Patients ("ACTINUT" Study)
Sedentary behavior and protein-energy wasting (PEW) are well known risk factors of adverse outcome and low quality of life in chronic renal failure patients treated by dialysis.
- Trial name
- ACTINUT (NCT01813851)
- Testing
- Exercise training in addition to nutritional support
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Nantes University Hospital
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement (Open-pilot)
The goal of this project is to conduct an open-pilot (N=30) to evaluate the feasibility, acceptability, and fidelity of a mind-body and activity program (GetActive+) with older adults with chronic pain.
- Trial name
- iHOPE (NCT05782231)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Glucose Metabolism Disorders, Liver Fibrosis
Change of Glucose Metabolism and Fibrosis Markers in Patients With Hepatitis C Under Treatment With Antiviral Agents
Chronic hepatitis C infection is associated with changes of glucose metabolism end increased frequency of impaired glucose tolerance. This might be a additional risk factor for disease and fibrosis progression.
- Conditions
- Glucose Metabolism Disorders, Liver Fibrosis, Hepatitis C
- Trial name
- NCT03908294
- Testing
- Lab tests, non-invasive fibrosis (Fibroscan/ARFI)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Unilateral Cerebral Palsy
Validation of AI for Personalized Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy
Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system.
- Trial name
- AInCP (NCT06073522)
- Testing
- Artificial Intelligence for combining multi-domain data acquisition
- Where
- 2 sites in Italy, Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Graft-versus-host-disease, Graft Versus Host Disease, Chronic
Physical Therapy in Patients Undergoing Allo-HSCT With cGVHD
Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) represents the only curative option for many patients diagnosed with various hematologic neoplasms.
- Conditions
- Graft-versus-host-disease, Graft Versus Host Disease, Chronic, Stem Cell Transplant Complications, Hematological Malignancy
- Trial name
- NCT06279585
- Testing
- Physical therapy
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- University of Seville
Physical Therapy, Low Back Pain
GRAVITY System Therapy on Chronic Low Back Pain
The aim of the study was to examine the effect of GRAVITY system therapy on chronic disc-related pain in lumbar spine. Investigators made a hypothesis that patients who regularly perform core strengthening exercises based on…
- Conditions
- Physical Therapy, Low Back Pain, Chronic Pain
- Trial name
- GRAVITY (NCT04765293)
- Testing
- Physical Therapy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Józef Piłsudski University of Physical Education
Deep Venous Thrombosis
Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities
The purpose of the study was to evaluate efficacy and safety of the new acute treatment of deep venous thrombosis by use of low-molecular-weight heparin compared with standard treatment using unfractionated heparin, especially…
- Trial name
- NCT00628576
- Testing
- unfractionated heparin, Tinzaparin (Leo)
- Where
- Denmark
- Volunteers
- 99 people
- Sponsor
- Aalborg University Hospital
Spinal Cord Injuries, Spina Bifida
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
The goal of this clinical trial is to learn about how a participation-based intervention builds capacity of youth with physical disabilities to pursue activities of their choice in the community.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT06007885
- Testing
- Pathways and Resources to Engagement and Participation (PREP)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Rehabilitation and Sleep Quality in COPD Patients
COPD affects 5 to 8% of the population in France. The disease consists of inflammation of the large and small airways causing permanent obstruction of the airways and symptoms such as dyspnea, cough and sputum that worsens over…
- Trial name
- REARSOM/BPCO (NCT06677268)
- Testing
- Rehabilitation
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Rouen
Steal Syndrome, Chronic Kidney Diseases
Hemodynamic Assessment of Distal Revascularization Interval Ligation
Our study seeks to define the effect of each component of the distal revascularization interval ligation (DRIL) procedure on the in vivo distal blood pressure of patients with ischemic steal, and to determine whether the interval…
- Conditions
- Steal Syndrome, Chronic Kidney Diseases, Arterio-Venous Fistula
- Trial name
- DRIL (NCT03054623)
- Testing
- DRIL procedure
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of South Florida
Long COVID-19
Long COVID-19 Intervention (COVIDL/MIQoL)
The goal of this clinical trial is to assess the effectiveness of a multicomponent intervention in individuals with Long COVID. The main questions it aims to answer are: Does the intervention increase quality of life, mental…
- Trial name
- COVIDL/MIQoL (NCT06492590)
- Testing
- Multicomponent intervention
- Where
- Spain
- Volunteers
- 74 people
- Sponsor
- Consorci Sanitari de Terrassa
Breast Cancer-Related Arm Lymphedema, Quality of Life Impairment
Prehabilitation of Breast Cancer-Related Lymphedema
This prospective prehabilitation study aims to evaluate the effects of an individualized exercise program initiated before breast cancer surgery and continued for 12 months postoperatively.
- Conditions
- Breast Cancer-Related Arm Lymphedema, Quality of Life Impairment, Fatigue Syndrome, Chronic, Prehabilitation
- Trial name
- NCT07301580
- Testing
- Prehabilitation Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
ESRD, Social Behavior
SOCIABLE Seniors Optimizing Community Integration to Advance Better Living With ESRD
This research is being done to find out the best ways to help people with end stage kidney disease take care of their daily lives and improve their social functioning.
- Conditions
- ESRD, Social Behavior, Physical Disability
- Trial name
- SOCIABLE (NCT03055273)
- Testing
- SOCIABLE
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
COPD
Effects of Two Training Protocols in Patients With Chronic Obstructive Pulmonary Disease
Introduction: There is evidence that demonstrate the beneficial effects of pulmonary rehabilitation programs (PR) on symptoms, exercise capacity, muscle strength and quality of life in patients with Chronic obstructive pulmonary…
- Trial name
- NCT01691131
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Norte do Paraná
Chronic Kidney Diseases
Does Hemodialysis Affect Upper Extremity Functional Capacity, Physical Activity and Physical Function of Patients?
This study was planned to determine the effects of upper extremity functional capacity, physical activity level and physical functions of patients receiving hemodialysis treatment.
- Trial name
- NCT04099953
- Testing
- Hand grip, joint range of motion , functional level of the upper extremity, physical activity levels
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NAİME ULUG
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