Clinical trials: Chronic Disease Lung
Pulmonary Disease, Chronic Obstructive
Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life
Dyspnea (shortness of breath) is a complex experience that includes interpretation of physical impairments and associated distress to the person.
- Trial name
- NCT00243282
- Testing
- Relaxation Response (instruction, pocket practice card prov), Mindfulness training using model developed from UMass
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
COPD, Sepsis
Effect of Nebulized Bronchodilators on Heart Rate
The purpose of the study is to determine adverse events rates of nebulized albuterol versus levalbuterol among adult critically ill patients and determine if a differential exists in adverse events between the two drugs.
- Conditions
- COPD, Sepsis, Shock
- Trial name
- NCT01151579
- Testing
- Levalbuterol, Albuterol
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Fahim Khorfan, MD
Chronic Obstructive Lung Disease
A Registry of COPD Patients to be Used for Future Studies
To develop a cohort of COPD participants to assist study staff in determining the most likely candidates for future studies.
- Trial name
- NCT00814203
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Philip Diaz
Respiratory Tract Diseases, Abnormal Mucus Secretions
A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions
This is a phase 3, multicenter, randomized, rater- and patient-blind, placebo- and active-controlled, 3-arm parallel group clinical trial.
- Trial name
- NCT03843541
- Testing
- N-acetylcysteine (NAC) 600 mg, Ambroxol hydrochloride 30 mg
- Where
- 32 sites in China
- Volunteers
- 333 people
- Sponsor
- Zambon SpA
COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation
Tele-Pulmonary Rehabilitation For COPD Patients Living in Peripheral Areas
Pulmonary rehabilitation (PR) is a key non-pharmacological intervention for patients with chronic obstructive pulmonary disease (COPD), yet it remains underutilized, particularly among patients living in peripheral areas due to…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation, Peripheral
- Trial name
- TELE-PR-PRPRL (NCT07666854)
- Testing
- Tele-Rehabilitation
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Dyspnea
Aerosol Inhalation Treatment for Dyspnea - Patients
The purpose of this protocol is to develop and test aerosol furosemide, as a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with intractable dyspnea.
- Trial name
- NCT02524054
- Testing
- Furosemide, Aerosolized saline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Improvement in COPD Elderly Patients Health: Study Protocol
Guidelines development, their implementation and the physicians' adherence may have an impact on the occurrence of Chronic Obstructive Pulmonary Disease (COPD) exacerbations and patient's quality of life.
- Trial name
- NCT04301505
- Testing
- Intervention 1, Intervention 2
- Where
- Poland
- Volunteers
- 2,520 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease
ADL- Training for Patients With Chronic Obstructive Pulmonary Disease (COPD)
ADL training of copd patients results in better execution of activities of daily living.
- Trial name
- NCT00887705
- Testing
- ADL training
- Where
- 2 sites in Norway
- Volunteers
- 24 people
- Sponsor
- LHL Helse
Chronic Respiratory Disease
(Re)Vitalizing Pulmonary Rehabilitation for Patients With Chronic Respiratory Diseases
3R aims to increase the access of patients with chronic respiratory diseases (CRD) to pulmonary rehabilitation (PR) in Portugal.
- Trial name
- 3R (NCT03799666)
- Testing
- Pulmonary Rehabilitation, Daily medication
- Where
- Portugal
- Volunteers
- 146 people
- Sponsor
- Aveiro University
HIV, COPD
Copenhagen Comorbidity in HIV Infection Study
Despite efficient antiretroviral treatment for HIV infection, decrease in life expectancy remains. Excess mortality is mainly due to non-AIDS co-morbidity including cardiovascular, pulmonary, and liver related diseases.
- Conditions
- HIV, COPD, CVD, Liver Disease
- Trial name
- COCOMO (NCT02382822)
- Testing
- No intervention.
- Where
- 2 sites in Denmark
- Volunteers
- 1,099 people
- Sponsor
- Susanne Dam Nielsen, MD, DMSc
Chronic Obstructive Pulmonary Disease (COPD)
Investigation of the Acute Effects of Traditional and Functional IMT on Muscle Oxygenation in COPD
This study aims to compare the effects of functional and conventional inspiratory muscle training (IMT) on post-exercise muscle deoxygenation in individuals with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT07267923
- Testing
- Traditional inspiratory muscle training, Functional inspiratory muscle training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Saglik Bilimleri Universitesi
Pulmonary Disease, Chronic Obstructive, Tobacco Smoking
COPD E-cigarette Topography Training
This study is for people with chronic obstructive pulmonary disease (COPD) and who smoke. Investigators are trying to find out if training on e-cigarette use will help smokers switch to e-cigarettes.
- Trial name
- NCT05510154
- Testing
- Brief advice, Single Training, Training to Competency
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Chronic Obstructive Pulmonary Disease
Imaging Progression of Chronic Obstructive Pulmonary Disease Using MRI and CT (MR-COPDII)
In this follow-up trial, MRI and CT images of the lung will be acquired prospectively in a subcohort of 370 patients, three years after they successfully participated in the first COSYCONET subtrial with CT and MRI ("MR-COPD I"…
- Trial name
- MR-COPDII (NCT03591562)
- Where
- 10 sites in Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Heidelberg
Infections, Heart Failure
Rural Hospital-Level Care at Home for Acutely Ill Adults
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infections, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05256303
- Testing
- Home Hospital care, Traditional Hospital care
- Where
- 3 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
COPD, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05435183
- Testing
- Non-invasive high-frequency oscillatory ventilation, Noninvasive Bilevel Positive Pressure Ventilation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
COPD
A Dose-Range Finding Study of SUN-101 in Subjects With Moderate to Severe COPD
Study for subjects 40 to 65 years-old with a diagnosis of moderate to severe COPD. Aclidinium bromide 400 mcg 2x a day will be given as an active comparator.
- Trial name
- GOLDEN 6 (NCT02038829)
- Testing
- SUN101 3 mcg, SUN-101 6.25 mcg, SUN-101 12.5 mcg
- Where
- 10 sites in United States
- Volunteers
- 96 people
- Sponsor
- Sunovion Respiratory Development Inc.
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Chronic Obstructive Pulmonary Disease
Effect on Adrenal Function of Budesonide Versus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD)
National Institute for Clinical Excellence (NICE) guidelines recommend high dose inhaled steroids for patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD, a common chronic disease related to smoking) who…
- Trial name
- NCT01186653
- Testing
- budesonide / formoterol, fluticasone/salmeterol
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Obstructive Pulmonary Disease, Lung Cancer
Accelerated Pulmonary Rehabilitation in the Preoperative Period
This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with…
- Trial name
- PREHAB (NCT06432972)
- Testing
- Pulmonary Rehab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Feeding Behavior, Chronic Lung Disease
Pilot Study Comparing Different Modes of Non-invasive Ventilation for the Oral Feeding of Preterm Infants
Preterm infants born before 28 weeks gestation are at risk for lung disease and require oxygen and pressure to keep their lungs open. This usually involves a device called nasal continuous positive airway pressure (nCPAP).
- Trial name
- CHOMP (NCT02055339)
- Testing
- Fisher & Paykel heated humidified high flow nasal cannula, InfantFlow/RAM nasal continuous positive airway pressure
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Mount Sinai Hospital, Canada
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