Clinical trials: Chronic Disease Lung
COPD
QualiTy of Life Evaluation in Patients With ChRonic ObstructIve Pulmonary Disease Who Require Tiotropium as additiOnal treatmeNt.
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous disease usually with a decline lung function and worsening symptoms; hence, both forced expiratory volume in 1 s (FEV1; lung function) and validated…
- Trial name
- TRITON (NCT06170125)
- Testing
- Tiotropium treated patients
- Volunteers
- 500 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Rehabilitation and Sleep Quality in COPD Patients
COPD affects 5 to 8% of the population in France. The disease consists of inflammation of the large and small airways causing permanent obstruction of the airways and symptoms such as dyspnea, cough and sputum that worsens over…
- Trial name
- REARSOM/BPCO (NCT06677268)
- Testing
- Rehabilitation
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Rouen
Chronic Obstructive Pulmonary Disease, Physical Activity
Promoting Physical Activity in Chronic Obstructive Pulmonary Disease (COPD) Through New Technology and Health Coaching
The objective of this project is to validate the proposed smartphone-based activity monitor and to test its use for Motivational Interviewing based counseling for physical activity in Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01217710
- Testing
- Activity monitor/smartphone health coaching
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History
The purpose of the study is to determine if benralizumab reduces COPD exacerbation rate in symptomatic patients with moderate to very severe COPD who are receiving standard of care therapies.
- Trial name
- TERRANOVA (NCT02155660)
- Testing
- Benralizumab Arm A, Benralizumab Arm B, Benralizumab Arm C
- Where
- 356 sites in United States, Argentina and 24 more
- Volunteers
- 2,255 people
- Sponsor
- AstraZeneca
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
The Impact of Indoor Environmental Quality on Symptoms in Patients With Chronic Obstructive Pulmonary Disease
This prospective, monocenter pilot study will investigate the relationship between indoor environmental quality (including air quality, lighting, noise, and thermal conditions), wearable-derived health insights, and…
- Trial name
- COPD-AIR (NCT07799896)
- Testing
- Wearable mobile device, Indoor environmental quality sensor, CAT Questionnaire
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Ziekenhuis Oost-Limburg
Deficiency of Vitamin D3, COPD
The Pittsburgh Vitamin D Study: Vitamin D Supplementation in Vitamin D-deficient Subjects at Risk of Lung Cancer
This study aims to establish the ability of 4,000 IU oral vitamin D3 per day (in combination with a daily multivitamin) to safely convert vitamin D3-deficient subjects at increased risk of lung cancer to a vitamin D3-sufficient…
- Trial name
- NCT02532062
- Testing
- Cholecalciferol, multivitamin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Chronic and Accelerated Silicosis
Safety of Stem Cells Intrabronchial Instillation for Silicosis
The aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (BMDMC, 2x107) through…
- Trial name
- SilicStemCell (NCT01239862)
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Migraine
A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder
This study is an open-label, parallel group study to evaluate acute pulmonary safety and Pharmacokinetics (PK) of two doses, separated by 2 hours, of CVT-427 zolmitriptan inhalation powder in three groups of adults: those with…
- Trial name
- NCT02905227
- Testing
- CVT-427 (zolmitriptan inhalation powder)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acorda Therapeutics
Copd, Dyspnea
Effect of Progressive Relaxation Exercıses on Dyspnea and Comfort Level in Individuals With COPD
The study is a randomised controlled experimental study conducted to examine the effect of progressive relaxation exercises on dyspnea and comfort level in individuals with chronic obstructive pulmonary disease.
- Conditions
- Copd, Dyspnea, Nursing Caries
- Trial name
- NCT06459882
- Testing
- progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Bakircay University
Chronic Obstructive Pulmonary Disease
Dose Ranging Study of Glycopyrronium Bromide in Patients With Moderate or Severe Chronic Obstructive Pulmonary Disease
This is an investigation of the beneficial effects, tolerability and safety of a range of single doses of orally inhaled glycopyrronium bromide (PSX1002GB pMDI) in male and female patients with moderate or severe chronic…
- Trial name
- NCT01703624
- Testing
- glycopyrronium bromide
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Prosonix Limited
Chronic Obstructive Pulmonary Disease
A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients
The goal of this observational registry study is to compare characteristics of gut and sputum microbiome and metabolome among COPD patients with significant smoking history, COPD patients without significant smoking history and…
- Trial name
- NCT06101459
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Bowel; Ischemic, Chronic, Tomography, X-Ray Computed
A Pilot Study on the Using a Newer Computed Tomography (CT) Based Technique for the Detection of Altered Bowel Blood Flow Among Patients Suffering From Chronic Mesenteric Ischemia During Meal Digestion.
Chronic meseteric ischemia (CMI) is a disease characterized by an insufficient blood supply to the intestines due to a narrowing (stenosis) of one or multiple intestinal arteries.
- Conditions
- Bowel; Ischemic, Chronic, Tomography, X-Ray Computed, Dual-energy CT
- Trial name
- NCT04794959
- Testing
- Dual-energy CT
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
COPD
Detect and Infer the Severity of COPD by Intelligent Terminal Device
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Early detection and treatment are critical to prevent the deterioration of COPD.
- Trial name
- NCT05551169
- Where
- 10 sites in China
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation
Tele-Pulmonary Rehabilitation For COPD Patients Living in Peripheral Areas
Pulmonary rehabilitation (PR) is a key non-pharmacological intervention for patients with chronic obstructive pulmonary disease (COPD), yet it remains underutilized, particularly among patients living in peripheral areas due to…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation, Peripheral
- Trial name
- TELE-PR-PRPRL (NCT07666854)
- Testing
- Tele-Rehabilitation
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cancer, Pain
A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain
The purpose of this study is to test the oxycodone/naloxone combination compared to oxycodone alone in patient's specific type of "chronic cancer pain".
- Conditions
- Cancer, Pain, Constipation
- Trial name
- NCT00513656
- Testing
- Oxycodone, Oxycodone/Naloxone
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pulmonary Disease, Chronic Obstructive
Effectiveness of Home Automated Telemanagement in Chronic Obstructive Pulmonary Disorder
All chronic obstructive pulmonary diseases (COPDs) block air flow to the lungs, and the two most common forms, emphysema and chronic bronchitis, are the most common causes of respiratory failure.
- Trial name
- NCT00752531
- Testing
- Home Automated Telemanagement (HAT)
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Johns Hopkins University
Myeloproliferative Disorders, Pulmonary Hypertension
Screening for Pulmonary Vascular Changes in Patients With Chronic Myeloproliferative Diseases
Goal of the study is to assess the frequency of pulmonary hypertension in patients with chronic myeloproliferative diseases. In each patient an echocardiography at rest will be performed.
- Trial name
- NCT01787162
- Testing
- Echocardiography, spiroergometry, cardiac catheterization
- Where
- Austria
- Volunteers
- 43 people
- Sponsor
- Medical University of Graz
Cholecystitis, Chronic
Comparison Between Oral Gabapentin Versus Diclofenac Sodium in Post-operative Analgesia Laparoscopic Cholecystectomy
this study amis to compare between perioperative oral Gabapentin versus Diclofenac sodium on postoperative analgesia patients undergoing laparoscopic cholecystectomy
- Trial name
- NCT07131527
- Testing
- Gabapentin, Diclofenac Sodium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
COPD
The Clinical Characteristics, Treatment and Prognosis of Tuberculosis-associated COPD
Chronic obstructive pulmonary disease (COPD) still imposes a substantial health and economic burden worldwide. Pulmonary tuberculosis has been confirmed as an important risk factor for COPD and this specific phenotype is thereby…
- Trial name
- NCT06074042
- Testing
- previous pulmonary tuberculosis
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Peking University Third Hospital
COPD
Inflammation in COPD and the Effect of Nicotinamide Riboside
The aim of this study is to investigate if nicotinamide riboside can reduce the airways inflammation associated with chronic obstructive pulmonary disease (COPD) in patients aged 60 or older.
- Trial name
- ICON (NCT04990869)
- Testing
- Nicotinamide Riboside
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
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