Clinical trials: Chronic Disease of Cardiovascular System
Diabetic Foot Ulcer (DFU), Amnio-Maxx
Effect of Amnio-Maxx on the Healing Rate of Chronic Diabetic Foot Ulcers.
This study will evaluate a cellular, acellular, matrix-like product (CAMP) and Standard of Care (SOC) versus SOC alone in the closure of nonhealing diabetic foot ulcers (DFUs).
- Trial name
- NCT07209475
- Testing
- Amnio-Maxx® Dual Layer Amnion Patch, Standard of Care (Investigator Choice)
- Where
- 8 sites in United States
- Volunteers
- 248 people
- Sponsor
- Royal Biologics
Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma
A Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex in Participants With Secondary Antibody Deficiency Associated With Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma
The main goal of this study is to show that people with certain immune problems (from Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma) get fewer serious infections when they receive Gamunex C through an IV…
- Trial name
- SIGMA (NCT07582432)
- Testing
- Gamunex-C, 10% Injectable Solution
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- Grifols Biologicals, LLC
Chronic Kidney Disease Stage 3 and 4, Peripheral Artery Disease (PAD)
Exercise Activity to Improve Mobility in Patients With CKD and PAD
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study.
- Trial name
- EXACT-CKDPAD (NCT06621264)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Control (Standard treatment)
- Where
- 3 sites in Italy
- Volunteers
- 124 people
- Sponsor
- University Hospital of Ferrara
Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO)
Clinical Outcomes of Drug-Coated Balloons in the Treatment of Patients With Coronary De Novo Chronic Total Occlusion Lesions
The aim of this study is to evaluate the long-term efficacy and safety of drug-coated balloon (DCB) strategies, including DCB alone or hybrid strategies of DCB and drug-eluting stent (DES), compared to DES-only in patients with…
- Conditions
- Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO), Coronary Artery Disease (CAD)
- Trial name
- DCB-CTO (NCT07463664)
- Testing
- DES Implantation, DCB Angioplasty
- Where
- 18 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies
This phase I multicenter feasibility trial is studying the safety and potential efficacy of infusing ex vivo expanded cord blood progenitors with one unmanipulated umbilical cord blood unit for transplantation following…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00343798
- Testing
- cyclophosphamide, fludarabine phosphate, cyclosporine
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Heart Failure, Cardiac Cachexia
Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia
The purpose of this study was to determine the effects of a high caloric drink on weight and several other clinical markers including quality of life in patients with unintentional weight loss (cachexia) due to chronic heart…
- Trial name
- NCT00654719
- Testing
- NutriDrink
- Where
- 2 sites in Germany, Poland
- Volunteers
- 29 people
- Sponsor
- National Heart and Lung Institute
Chronic Heart Failure, Type 2 Diabetes
The Effects of Glimepiride in Patients With Type 2 Diabetes and Chronic Heart Failure
Thirty years ago, Dzau and Braunwald introduced the concept of a continuum of cardiovascular diseases and defined them as a series of events caused by numerous related and unrelated risk factors, thus developing to end-stage…
- Conditions
- Chronic Heart Failure, Type 2 Diabetes, Cardiovascular Mortality, Cohort Study
- Trial name
- EGPT2D&CHF (NCT05538819)
- Testing
- Glimepiride
- Where
- China
- Volunteers
- 1,018 people
- Sponsor
- Dao Wen Wang
Pulmonary Hypertension
Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience)
Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications . PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the…
- Trial name
- NCT02774928
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited
Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Other B-cell Cancers
RATIONALE: Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and kill more cancer cells.
- Trial name
- NCT00003163
- Testing
- filgrastim, sargramostim, cyclophosphamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical College of Wisconsin
Upper Extremity Paresis
Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke
Stroke often leads to long-term disability including upper extremity (UE) dysfunction even with the provision of timely rehabilitation services.
- Trial name
- NCT03964467
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of the Sciences in Philadelphia
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Heart Failure
Evaluation of Clinical and Genetic Modifiers of Long-term Survival in Heart Failure
The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.
- Trial name
- NCT03461107
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Tongji Hospital
Chronic Stable Angina
The Effects of Inorganic Nitrate on Cardiac Muscle in Angina
Previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen…
- Trial name
- NCT02078921
- Testing
- Sodium Nitrate
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Heart Failure, Congestive
Prednisone for Decompensated Congestive Heart Failure
We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical status when added to standard care.
- Trial name
- NCT00369044
- Testing
- prednisone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University
Critical Limb Ischemia, Arterial Occlusive Disease
Safety Study of Adult Stem Cells to Treat Patients With Severe Leg Artery Disease
Peripheral artery disease (PAD) due to leg artery blockages can result in painful leg muscles, skin ulcers and infection due to poor blood flow. In severe forms, the only treatment may be amputation.
- Conditions
- Critical Limb Ischemia, Arterial Occlusive Disease, Vascular Diseases
- Trial name
- SCRIPT-CLI (NCT00913900)
- Testing
- autologous CD133+ cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Hypertension
A Comparison of Compliance Between Clonidine Patch and Methyldopa for the Treatment of Chronic Hypertension in Pregnancy
High blood pressure (BP) before pregnancy is called chronic hypertension (CHTN), and is associated with an increased risk of development of pregnancy related high BP called preeclampsia, preterm delivery, decreased growth of the…
- Trial name
- NCT00329511
- Testing
- methyldopa vs. clonidine, clonidine patch
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Afshan B. Hameed, M.D.
Diabetic Foot Ulcer
Efficacy and Safety Study of Dermal-Living Skin Replacement to Treat Diabetic Foot Ulcers
The purpose of this study is to test the efficacy and side effects, if any, of Dermal - LSR combined with standard treatment. We hypothesize the treatment will provide beneficial results for diabetic patients suffering foot…
- Trial name
- NCT00368693
- Testing
- Dermal - Living Skin Replacement (Dermal-LSR)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Subdural Hematoma
MMA Embolization With NeoCast for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the NeoCast Embolic System for treatment of symptomatic subacute or chronic subdural hematoma (SDH)…
- Trial name
- RADIANT (NCT07541404)
- Testing
- NeoCast Embolic System, Onyx LES, an FDA-Approved Commercial Liquid Embolic
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Arsenal Medical, Inc.
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