Clinical trials: Chronic End Stage Renal Failure
End Stage Renal Disease (ESRD), Chronic Kidney Disease Requiring Hemodialysis
Ultrasound Prediction of Successful Balloon Assisted AVF Maturation
An arteriovenous fistula (AVF) is created to allow for cleaning of the blood in patients with severe kidney disease. An artery and a vein are surgically connected, typically in the arm.
- Trial name
- NCT06771973
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
End Stage Renal Disease
Impact of Black Seed Oil on Hemodialysis Patients
The aim of the study is to evaluate the effect of black seed oil on endothelial dysfunction, oxidative stress and quality of life in hemodialysis patients.
- Trial name
- NCT05822661
- Testing
- Black Seed Oil
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Cognitive Impairment, End-Stage Renal Disease
Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease
The purpose of this study is to evaluate the impact of 12 weeks of exercise on cognition in patients with end stage renal disease.
- Trial name
- NCT02145702
- Testing
- Aerobic Exercise, Standard Care Dialysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Kidney Diseases, Chronic Kidney Diseases
Pathways Project: Kidney Supportive Care
The Pathways Collaborative is the first attempt to implement supportive (palliative) kidney care at multiple sites in the United States.
- Conditions
- Kidney Diseases, Chronic Kidney Diseases, End Stage Renal Disease, End Stage Renal Disease on Dialysis
- Trial name
- NCT04125537
- Testing
- IHI Breakthrough Collaborative Model
- Where
- 13 sites in United States
- Volunteers
- 476 people
- Sponsor
- George Washington University
Microcirculatory Status, Spectroscopic Analysis
Near-Infrared Spectroscopy Measurements in Chronic Obstructive Pulmonary Disease
Participants were selected based on three groups: healthy, chronic obstructive pulmonary disease, and chronic renal disease. NIRS was used to measure tissue oxygenation on the thenar region of the right hand.
- Conditions
- Microcirculatory Status, Spectroscopic Analysis, COPD, Renal Failure
- Trial name
- NIRS (NCT06976762)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Chronic Kidney Disease
The Canadian Prevention of Renal and Cardiovascular Endpoints Trial
Advanced kidney disease with it's associated heart and blood vessel problems are becoming more frequent. These problems markedly affect length and quality of life and cost a lot to treat.
- Trial name
- CanPrevent (NCT00231803)
- Testing
- Combined CKD and CVD Prevention, Cardiovascular Disease prevention, Treatment of Chronic Kidney Disease complications
- Where
- 5 sites in Canada
- Volunteers
- 474 people
- Sponsor
- Brendan Barrett
End Stage Kidney Disease, Chronic Kidney Diseases
The WavelinQ™ Arterio-Venous Endovascular Fistula: A Global, Post-Market Investigation
This is a global, multi-center, prospective, post-market, confirmatory, interventional, non-randomized, single-arm clinical investigation evaluating arteriovenous fistula (AVF) creation by means of the WavelinQ™ EndoAVF System in…
- Conditions
- End Stage Kidney Disease, Chronic Kidney Diseases, Kidney Failure, Kidney Insufficiency
- Trial name
- WAVE-Global (NCT04626427)
- Testing
- WavelinQ™ EndoAVF System
- Where
- 3 sites in Belgium, Greece and 1 more
- Volunteers
- 21 people
- Sponsor
- C. R. Bard
End Stage Renal Disease
Effects of Oral Cholecalciferol (Vitamin D3) on Bone Health, Neuromuscular Function, and Quality of Life in Adults With Chronic Kidney Disease
Will oral vitamin improve strength, bone quality, pain and quality of life. This is a double blind, randomized placebo controlled study using 10,000 IU of cholecalciferol vs placebo.
- Trial name
- Neph (NCT00511225)
- Testing
- cholecalciferol
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Creighton University
End Stage Renal Disease
A Study to Evaluate the Safety and Efficacy of Paricalcitol Capsules in Reducing Serum Intact Parathyroid Hormone Levels in End Stage Renal Disease Subjects on Peritoneal Dialysis
To determine the safety and efficacy of paricalcitol capsules as compared to placebo for treatment of secondary hyperparathyroidism by decreasing serum intact parathyroid hormone levels in end stage renal disease subjects on…
- Trial name
- NCT00646035
- Testing
- paricalcitol capsules
- Where
- 24 sites in United States, Poland
- Volunteers
- 75 people
- Sponsor
- Abbott
End Stage Renal Disease, Pruritus
DIalysis Symptom COntrol-Pruritus Outcome Trial
The purpose of this study is to test whether or not a medication called nabilone, which is a synthetic (non-natural) medication derived from cannabis, compared to placebo improves symptoms of itch in hemodialysis as measured by…
- Trial name
- DISCO-POT (NCT05180968)
- Testing
- Nabilone 0.5 MG Oral Capsule
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
End-Stage Kidney Disease (ESKD), Maintenance Hemodialysis (MHD)
Health Coaching for Self-Management in Maintenance Hemodialysis Patients
This study is a quasi-experimental study designed to evaluate the effects of a health coaching intervention on self-management ability in patients undergoing maintenance hemodialysis.
- Trial name
- NCT07685626
- Testing
- Health Coaching, Routine Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
End Stage Renal Disease, Antibody Mediated Rejection
Belatacept in Kidney Transplantation of Moderately Sensitized Patients
The purpose of this study is to evaluate the safety and effectiveness of an immunosuppressive medication, Belatacept, as a replacement for a calcineurin inhibitor, in combination with a standard of care regimen of…
- Trial name
- BelatPilot (NCT02130817)
- Testing
- Belatacept, Tacrolimus withdrawal, Plasmapheresis/Intravenous Immunoglobulin G
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Inflammation, End-stage Renal Disease
Use of Telmisartan and Captopril in Inflammation of Hemodialysis Patients
The aim of this study was to compare the dual use of telmisartan and captopril vs the individual use of such drugs and placebo on the systemic inflammation of patients on hemodialysis (HD).
- Trial name
- NCT01271478
- Testing
- Telmisartan plus Captopril
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Renal Impairment
Pharmacokinetics, Safety and Tolerability of AGO178C in Subjects With Renal Deficiencies Compared With Healthy Subjects
This study will assess the pharmacokinetics, safety and tolerability of a single dose of AGO178C in subjects with mild, moderate, severe renal impairment and end-stage renal disease with that in healthy matched control subjects.
- Trial name
- NCT01459250
- Testing
- AGO178C
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Uremia, Chronic Renal Failure
Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events
Homocysteine recently gained access to the category of risk factor for the development of atherosclerotic cardiovascular disease in the general population.
- Conditions
- Uremia, Chronic Renal Failure, Hemodialysis, Hyperhomocysteinemia
- Trial name
- NCT00317005
- Testing
- folate treatment
- Where
- 2 sites in Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Estadual de Londrina
Cytomegalovirus (CMV), Kidney Disease
A Study of Maribavir in Adults With Kidney Failure Who Have a Cytomegalovirus (CMV) Infection After Transplantation
The main aim of this study is to assess the safety of maribavir in adults with severe CKD or comorbid ESRD including participants on artificial filtering of the kidney (dialysis) or the blood (hemodialysis).
- Conditions
- Cytomegalovirus (CMV), Kidney Disease, Kidney Failure
- Trial name
- NCT06243731
- Testing
- No Intervention
- Where
- 25 sites in Belgium, Estonia and 5 more
- Volunteers
- 10 people
- Sponsor
- Takeda
Chronic Renal Failure
Does Intravenous Iron Therapy Decrease Serum Phosphorous Levels?
Intravenous iron therapy is common and effective, with few side effects. Two formulations are used, venofer or iron sucrose and ferrlecit, or ferric gluconate.
- Trial name
- NCT02420119
- Testing
- non interventional
- Where
- Israel
- Volunteers
- 53 people
- Sponsor
- Frieda Wolf
Chronic Kidney Diseases, Chronic Kidney Disease stage3
Living With CKD: An E-Learning Platform for Adolescents With CKD About the Disease and Its Management
Leveraging a unique combination of synchronized web and mobile applications, this 3 year SBIR Phase II project will fully develop and pilot test My Kidney Guru-a program that will offer pediatric patients with CKD developmentally…
- Conditions
- Chronic Kidney Diseases, Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage V
- Trial name
- CKD Delp (NCT05630729)
- Testing
- My Kidney Guru
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- 3-C Institute for Social Development
End Stage Renal Disease
Theranova Versus High-flux Dialyzer on Preservation of Residual Renal Function
Theranova is a novel medium cut-off dialyzer and has better performance for removal of middle molecules compared to conventional hemodialysis.
- Trial name
- THREAD (NCT04211571)
- Testing
- Theranova 400 dialyzer, High-flux dialyzer
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungpook National University Hospital
End Stage Renal Disease
Clinical Performance Comparison of 2 THERANOVA 400 Dialyzer Prototypes in HD With High-Flux Dialyzers in HD and hv HDF Mode
The study investigates the performance of a new dialyzer (Theranova 400) containing a membrane with increased pore sizes. The performance will be determined by the removal of middle molecules (with different molecular size) from…
- Trial name
- NCT02377622
- Testing
- THERANOVA 400 dialyzer prototype AA, THERANOVA 400 dialyzer prototype BB, FX CorDiax 80 Dialyzer
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Vantive Health LLC
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