Clinical trials: Chronic Graft-versus-host-disease
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Obstructive Pulmonary Disease
COPD Assessment and Management Bundle Versus Usual Care
Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory (lung) disease that makes it harder to breathe over time.
- Trial name
- NCT01833026
- Testing
- Spirometry test, Levalbuterol
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Illinois Chicago
Chronic Obstructive Pulmonary Disease
A Clinical Trial of TQC3721 Suspension for Inhalation
To evaluate the safety, tolerability and pharmacokinetic characteristics of TQC3721 suspension for inhalation in single/multiple administration(s) in healthy subjects; to evaluate the safety,tolerability and efficacy TQC3721…
- Trial name
- NCT05051930
- Testing
- TQC3721 suspension for inhalation
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency
Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)
This is a multicenter, parallel-group, double-blind, randomized phase 4 study designed to identify the optimal dose of CE1226 (2 active doses) to slow disease progression as assessed by reduced rates of annual lung density…
- Conditions
- Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency, Emphysema
- Trial name
- NCT07326592
- Testing
- CE1226
- Where
- 2 sites in Denmark
- Volunteers
- 270 people
- Sponsor
- CSL Behring
Chronic Sinusitis, Adenoid Disease - Chronic
Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children
The objectives of this study would be to determine the most effective management for pediatric patients with chronic rhinosinusitis and asthma who fail medical management.
- Trial name
- NCT03336671
- Testing
- Endoscopic Sinus surgery, Adenoidectomy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Aortic Dissection Type B
Dragon Study Europe
Dragon Study Europe is an international, multicenter, prospective, non-randomized study. It is designed to evaluate safety and performance of the MFM for the treatment of chronic type B aortic dissection.
- Trial name
- NCT03033771
- Testing
- Implantation with the Multilayer Flow Modulator (MFM)
- Where
- 4 sites in Bulgaria, Romania
- Volunteers
- 27 people
- Sponsor
- Cardiatis
Chronic Kidney Diseases
Protecting Kidneys Through a Low Protein Diet: A Stepwise Multiple-Choice System Approach
Nephrology care continues to progress and recommendations are now focused on delaying as much as possible the need for renal replacement therapy ("intent-to-defer"strategy).
- Trial name
- ProReRePro (NCT03979534)
- Testing
- low protein diet
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier le Mans
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll
Chronic Obstructive Pulmonary Disease
A RESearch on the PrEvalence and the Diagnosis of COPD and Its Tobacco-related Etiology
The aim of the RESPECT study is to gain a better understanding of the prevalence, pathogenesis and symptoms of early chronic obstructive pulmonary disease (COPD).
- Trial name
- RESPECT (NCT02307799)
- Where
- 2 sites in Russia
- Volunteers
- 3,133 people
- Sponsor
- Université Catholique de Louvain
Chronic Kidney Disease-associated Pruritus
The MC2-25 Cream in Subjects wITh CHronic KIdNEy Disease-aSsociated prurituS (ITCHINESS) Trial
The purpose of this study is to access the efficacy and safety of MC2-25 cream and MC2-25 vehicle for treatment of chronic kidney disease associated pruritus (CKD)-aP).
- Trial name
- ITCHINESS (NCT05482698)
- Testing
- MC2-25 cream, MC2-25 vehicle
- Where
- United Kingdom
- Volunteers
- 111 people
- Sponsor
- MC2 Therapeutics
Acute Pain, Chronic Postsurgical Pain
The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery
This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.
- Trial name
- NCT03847363
- Testing
- epidural anesthesia, nerve block
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Refractory Chronic Migraine
Ketamine and Lidocaine Infusion in Refractory Chronic Migraine
Ketamine and lidocaine infusion for refractory chronic migraine: Comparative Study
- Trial name
- NCT06935552
- Testing
- Ketamine infusion, Lidocaine Intravenous Infusion, Dextrose 5% in water
- Volunteers
- 44 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease
CLEAR Model for Predicting Ventilatory Liberation in Severe COPD
This prospective observational cohort study aims to prospectively evaluate and validate the Clinical Load, Exchange, Ability of Respiration, and Reserve (CLEAR) model for predicting sustained ventilatory liberation in patients…
- Trial name
- CLEAR (NCT07579052)
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Cerebral Palsy
A Gamified Breathing and Postural Awareness Education Model for Children With Cerebral Palsy
This project aims to develop an accessible, learning-oriented model based on gamified breathing and posture training that emphasizes active participation for children with cerebral palsy (CP), their families, and educators.
- Trial name
- NEFES-CP (NCT07681947)
- Testing
- N.E.F.E.S.-CP Education Model
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yeditepe University
Obstructive Chronic BronchoPneumopathy (OCBP)
4-10 Week Observational Study Comparing 3 Management Strategies for Obstructive Chronic BronchoPneumopathy (OCBP) in Common Clinical Practice
The management of patients with Obstructive Chronic BronchoPneumopathy (OCBP) is based on a progression of therapeutic options and on a sensitization to physical activity.
- Trial name
- OBALPA (NCT01885247)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Acute Pain, Chronic Pain, Widespread
Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain
This is a clinical trial that intend to determine the effects of S-ketamine on event-related potentials associated with semantic affective pain-processing
- Conditions
- Acute Pain, Chronic Pain, Widespread, Schizophrenia
- Trial name
- NCT03915938
- Testing
- Ketamine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Heart Failure, Central Sleep Apnea
French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS)
The purpose of FACE study is to provide in routine practice complementary long-term data on the mortality and morbidity of Chronic Heart Failure (CHF) patients with Central Sleep Apnea eligible for Adaptative Servo-Ventilation…
- Trial name
- FACE (NCT01831128)
- Testing
- ASV Treatment
- Where
- 18 sites in France
- Volunteers
- 509 people
- Sponsor
- ResMed
Chronic Low Back Pain
Aging Back Clinics
The purpose of this study is to compare two different ways to treat chronic low back pain. The two types of treatment that the investigators will compare are called Usual Care and ABC Care. Usual Care tends to focus on the spine.
- Trial name
- NCT03564600
- Testing
- Aging Back Clinics management
- Where
- 3 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ankle Injuries
Percussive Therapy Reduced EMG Activity During Calf Raise in Limbs With and Without Chronic Ankle Instability
To examine the acute effect of percussive therapy on peak calf muscle activation during standing heel raise in subjects with and without chronic ankle instability (CAI).
- Trial name
- NCT06343207
- Testing
- Percussive massage gun therapy
- Where
- Czechia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
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