Clinical trials: Chronic Headache, active
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Migraine in Adults
EXErcise in MIGraine
The study project aims to implement therapeutic patient education for migraine, promoting improvement in outpatient clinical practice by providing counseling moments specifically dedicated to known health risk factors (sedentary…
- Trial name
- EXEMIG/01 (NCT07508449)
- Testing
- exercise program supervised by specialized kinesiologists, Standard neurological visit at the Headache Centre
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Centro Universitario Ricerca Interdipartimentale Attivita' Motoria
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Chronic Migraine, Headache
Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine.
PRF performed on the sphenopalatine ganglion level under ultrasound guidance. Standard voltage PRF parameters: 45 V, 5 Hz frequency, 5 ms pulse width, 360 seconds duration, electrode temperature ≤42°C.
- Trial name
- NCT07500558
- Testing
- Standarad PRF, Supravoltage PRF
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Migraine Disorder, Low Back Pain
Sleep Hygiene Education to Improve Sleep in Chronic Migraine and Back Pain
The goal of this clinical trial is to learn whether sleep hygiene education can improve sleep quality and reduce pain in adults with migraine and/or chronic lower back pain.
- Conditions
- Migraine Disorder, Low Back Pain, Chronic Pain, Sleep Disorder (Disorder)
- Trial name
- NCT07425964
- Testing
- Sleep Hygiene Education
- Volunteers
- 100 people
- Sponsor
- Aalborg University
Cervicogenic Headache, Chronic Neck Pain
Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls
The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck.
- Trial name
- NCT07776275
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Migraine Headache, Psychologic Adaptation
Psychological Support for Chronic Migraine Patients Treated With Anti-CGRP (Anti-Calcitonin Gene-Related Peptide ) Monoclonal Antibodies
Chronic migraine is a disabling neurological condition that can significantly affect quality of life, emotional well-being, social participation, and daily functioning.
- Trial name
- MIG-PSY-CGRP (NCT07877493)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Migraine Headache, Transcranial Direct Current Stimulation
TCDS for the Treatment of Chronic Migraine
Migraine affects 1 in 7 people worldwide, but for those suffering from chronic migraine there is a need for safe, effective and well tolerated treatments.
- Trial name
- NCT07214454
- Testing
- Transcranial direct current stimulation (Nettle device) 2mA stimulation for 20 minutes per day
- Volunteers
- 20 people
- Sponsor
- University College, London
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Chronic Migraine, Chronic Migraine, Headache
Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic…
- Trial name
- NCT06684249
- Testing
- Nerve Block Injections, Botulinum Toxin A
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Zagazig University
Chronic Daily Headache, Chronic Migraine
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal…
- Trial name
- NCT03231241
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Pain, Migraine
Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment
The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain.
- Conditions
- Chronic Pain, Migraine, Chronic Pain Syndrome
- Trial name
- NCT07143396
- Testing
- Mind-body mobile application and guided movement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of the Fraser Valley
Chronic Migraine, Adverse Childhood Experiences
Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences
This study aims to evaluate the effectiveness of an online Mindfulness-Based Cognitive Therapy (MBCT) program in reducing pain, stress-related symptoms, and improving functionality in adults with chronic migraine and a history of…
- Conditions
- Chronic Migraine, Adverse Childhood Experiences, Depression, Anxiety
- Trial name
- NCT07033520
- Testing
- Online Mindfulness-Based Cognitive Therapy
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Fundación Cardiovascular de Colombia
Post-Concussion Symptoms, Insomnia
Neurotechnology Following Traumatic Brain Injury
This two-part study seeks to improve symptoms such as pain and sleep problems after concussion, or mild traumatic brain injury (mTBI).
- Conditions
- Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
- Trial name
- Cereset (NCT03649958)
- Testing
- HIRREM-SOP or Cereset, Cereset 2x
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Brain State Technologies, LLC