Clinical trials: Chronic Health Conditions
Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football…
- Trial name
- NCT04796207
- Testing
- Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Chronic Pain, Fibromyalgia
Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women
Chronic pain disproportionately affects women and may coexist with impaired bone health, particularly during midlife and after menopause.
- Conditions
- Chronic Pain, Fibromyalgia, Osteoporosis, Orofacial Pain
- Trial name
- ORION (NCT07783295)
- Testing
- Full-Spectrum Cannabis Extract 5:1 (CBD:THC)
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Associação Pan-Americana Multidisciplinar de Endocanabinologia
Tobacco Smoking, Alcohol-Related Disorders
Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease
Many Veterans who have chronic conditions like cardiovascular disease or diabetes smoke or drink too much alcohol, which can worsen the condition.
- Trial name
- MINDSET (NCT07039175)
- Testing
- MINDSET, Usual Care
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Air Pollution and Health of COPD Patients
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
- Trial name
- NCT05076630
- Testing
- Air pollutants
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University
Obesity
Application of Dietary Guidelines for the Brazilian Population by Teleconsultation in Obesity in Primary Care
Obesity is a chronic disease that is highly prevalent in Brazil. It is associated with diabetes and hypertension. Obesity may decrease quality of life.
- Trial name
- NCT05171907
- Testing
- Teleobesity
- Where
- Brazil
- Volunteers
- 578 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Pain, Chronic, Pain, Intractable
APP-based Precise Management System of Chronic Intractable Pain
The goal of this clinical trial is to learn about a new management system in chronic and stubborn pain patients who accept therapy of spinal cord stimulation (SCS).
- Trial name
- PreMaSy (NCT05761392)
- Testing
- Precise management
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Diabetes, Heart Disease
The CREATE Wellness Study
Cardiovascular disease (CVD) is the leading cause of death in the U.S. Efforts to improve CVD risk factors often fall short in complex patients with multiple co-morbid conditions, a growing, expensive, and high-risk segment of…
- Conditions
- Diabetes, Heart Disease, Hypertension, Dyslipidemia
- Trial name
- NCT02302612
- Testing
- CREATE Wellness, Usual Care Control
- Where
- United States
- Volunteers
- 647 people
- Sponsor
- Kaiser Permanente
COVID-19, Long Haul
Covid-19 Long Haul Preventative and Health Promotion Care Clinical Trial Acceleration Program.
Investigators are conducting a study on alternative treatments for patients who have received an current or previous positive COVID-19 diagnosis with mild-serve symptoms or undiagnosable condition after testing positive for…
- Trial name
- NCT06441955
- Testing
- Ritonavir-Boosted Nirmatrelvir (Paxlovid), Physiological Evaluation, Moderna COVID-19 Vaccine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Well- Konnect Healthcare Services and Research Firm
COPD, Depression
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk.
- Conditions
- COPD, Depression, Anxiety
- Trial name
- NCT04953806
- Testing
- Step-CBT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Multiple Chronic Conditions, Patient Engagement
AI-Augmented Motivational Interviewing Training for Primary Care
This study will examine the impact of training primary care providers (PCPs) in motivational interviewing (MI) using artificial intelligence (AI) to augment the training process.
- Conditions
- Multiple Chronic Conditions, Patient Engagement, Burnout, Professional, Motivational Interviewing
- Trial name
- AIM-PC (NCT06597123)
- Testing
- Basic AI (artificial intelligence)-Augmented Motivational Interviewing Training, Plus AI (artificial intelligence)-Augmented Motivational Interviewing Training
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Wright State University
Mental Illness, Chronic Disease
Comparative Effectiveness of IIMR Versus CDSMP
The study will enroll 600 people with serious mental illness who receive services at Centerstone in KY or TN and will compare two different evidence-based self-management interventions: Integrated Illness Management and Recovery…
- Trial name
- NCT03966872
- Testing
- Integrated Illness Management and Recovery, Chronic Disease Self-Management Program
- Where
- 2 sites in United States
- Volunteers
- 601 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Depression, Anxiety
The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners
The purpose of this study is to examine relationships between contextual stressors and stress moderators, depression symptom experience, resilience, frailty, and quality of life among older sexual gender minorities cancer…
- Conditions
- Depression, Anxiety, Caregiver Burden, Stress
- Trial name
- SGMC (NCT05866705)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Chronic Back Pain, Chronic Pain
Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)
The goal of this observational intervention study is to evaluate the impact of a multidisciplinary active coping program for chronic back pain in adults referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche.
- Conditions
- Chronic Back Pain, Chronic Pain, Back Pain, Low Back Pain, Chronic
- Trial name
- NCT07504094
- Testing
- Pain Neuroscience Education (PNE), Healthy Habits and Psychological Intervention, Therapeutic Exercise
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Universidad de Zaragoza
Cerebral Palsy
Early Remote At-risk Diagnosis for Cerebral Palsy in Follow-up Clinics for High-risk Infants
Cerebral Palsy (CP) is the most common motor dysfunction in childhood. Traditionally, diagnosis is set between 12 and 24 months of age.
- Trial name
- In-Motion (NCT04287166)
- Where
- 3 sites in Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Disease, Chronic
Heart Transplant Patients, Health Status and Physical Activity
The aim of this cross-sectional observational study is (1) to assess the health status of a group of heart transplant patients and their level of physical activity, (2) and to compare the health status of a group of heart…
- Trial name
- NCT05282342
- Testing
- Diagnostic tests
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Luis Santos
COVID-19, Chronic Disease
The Psychological, Social, and Economic Impacts of COVID-19
A dynamic analytical tool is being implemented to monitor the health, psychosocial and economic impacts of the COVID-19 pandemic as the crisis unfolds.
- Conditions
- COVID-19, Chronic Disease, Psychiatric Disorder, Cardiovascular Diseases
- Trial name
- C19Survey (NCT04369690)
- Where
- 10 sites in Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ottawa