Clinical trials: Chronic Heart Disease
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy
Patients who developed an acute coronary syndrome despite dual antiplatelet therapy with aspirin and clopidogrel may benefit from a further dose of clopidogrel before a percutaneous coronary intervention.
- Trial name
- NCT01572129
- Testing
- Clopidogrel
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Campus Bio-Medico University
Stroke, Osteopathic Medicine
Examining Relationships Between Musculoskeletal Function Measurements of Movement Efficiency and Nervous System Function After Chronic Stroke
Stroke remains the leading cause of severe disability, and survivors frequently have incomplete recovery. More than half of older survivors have impaired mobility which contributes to poorer quality-of-life (QoL) and suffering.
- Conditions
- Stroke, Osteopathic Medicine, Physical Examination, Heart Rate Variability (HRV)
- Trial name
- SOMADC-CC (NCT07737873)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Long Covid19, Autonomic Dysfunction
Autonomic Nervous System Affection Due to Post Covid Syndrome
Post-Covid syndrome is defined as symptoms that develop in addition to respiratory symptoms in individuals who have had Covid-19 infection for more than 12 weeks.
- Trial name
- NCT05502094
- Testing
- Heart Rate Variability Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Ischemic Heart Disease Chronic
Effectiveness and Cost-effectiveness of a VCoP to Empowerment of Patients With Ischaemic Heart Disease in PHC: Cluster-RCT
Objective: to evaluate the effectiveness and estimate the costs of a Virtual Community of Practice in the improvement of the activation of patients with Ischemic Heart Disease in Primary Care .
- Trial name
- Empodera-dos (NCT03959631)
- Testing
- Virtual Communities of practice
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
End-stage Kidney Disease, Hemodialysis
Exercise and Cardiac Stunning During HD
The purpose of this study is to determine the effect of a 12-week cycling during hemodialysis program on hemodialysis-induced myocardial stunning in adult individuals receiving hemodialysis.
- Trial name
- NCT04877041
- Testing
- Intradialytic Cycling
- Where
- 6 sites in Australia, Canada
- Volunteers
- 111 people
- Sponsor
- University of Manitoba
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Rutgers University Study of the Genetics of Pulmonary Hypertension
The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required.
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
- Trial name
- RUGCC-PH (NCT07217522)
- Testing
- Saliva sample, Health surveys
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
End Stage Renal Disease
Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study B
The purpose of this study is to test the feasibility of trials that change the dialysis ultrafiltration rate (UFR) by limiting the maximum rate and to estimate the extent to which limiting the ultrafiltration rate reduces the…
- Trial name
- RADAR-B (NCT03519360)
- Testing
- UFR-restricted dialysis, UFR-unrestricted dialysis
- Where
- United States
- Sponsor
- NYU Langone Health
Heart Failure
PDE5-Inhibition With Sildenafil in Chronic Heart Failure
To test the hypothesis that long-term PDE5-inhibition by overexpressing the nitric oxide pathway is beneficial in chronic heart failure patients. Double-blind and placebo-controlled trial.
- Trial name
- NCT00407446
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Infection, Heart Failure
Prediction of Patient Deterioration Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05045742
- Testing
- Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Brigham and Women's Hospital
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Ischemic Heart Disease
In-hospital and Long-term Outcomes for Percutaneous Chronic Total Coronary Occlusion Revascularization in a High-volume, Multi-operator Program
The purpose of this study is to study whether percutaneous chronic total occlusion (CTO) revascularization, by the use of Percutaneous Coronary Intervention (PCI), stenting, guidewire, and catheter, improves a patient's quality…
- Trial name
- Perspective (NCT01946724)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Piedmont Healthcare
Heart Failure
iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure.
- Trial name
- iCardia4HF (NCT06205225)
- Testing
- Text4HF, MyApps, MyApps & Text4HF
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- University of Illinois Chicago
Chronic Kidney Diseases, Renal Failure
IntraRenal HEmoDynamics to IntegraTE CA-AKI Risk and Monitor NephroprotectiIoN by ImpElla Support.
the hypothesis is that elevation of the intrarenal resistive index (RI) characterizes patients at elevated risk for subsequent CA-AKI and integrates items of the Mehran AKI risk score into a single, readily obtainable parameter.
- Conditions
- Chronic Kidney Diseases, Renal Failure, Coronary Artery Disease
- Trial name
- NCT06599424
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 550 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Coronary Syndrome, Chronic Coronary Syndrome
Common Femoral Vein-to-Artery Diameter Ratio for Detection of Elevated LVEDP
This prospective cross-sectional diagnostic accuracy study enrolled patients undergoing coronary angiography and left heart catheterization at Burapha University Hospital, Thailand.
- Conditions
- Acute Coronary Syndrome, Chronic Coronary Syndrome, Heart Failure
- Trial name
- NCT07866859
- Testing
- Ultrasound Measurement of Common Femoral Vein-to-Artery Diameter Ratio
- Where
- Thailand
- Volunteers
- 105 people
- Sponsor
- Burapha University
Heart Failure
Jardiance® Post Marketing Surveillance (PMS) in Korean Patients With Chronic Heart Failure
The primary objective of this study is to monitor the safety profile of Jardiance® in Korean patient with chronic heart failure (New York Heart Association (NYHA) class II-IV) in a routine clinical setting.
- Trial name
- NCT05236673
- Testing
- JARDIANCE®
- Where
- 21 sites in South Korea
- Volunteers
- 676 people
- Sponsor
- Boehringer Ingelheim
AKI - Acute Kidney Injury
Efficacy and Safety of SP16 in Preventing Acute Kidney Injury in At-risk Subjects With Chronic Kidney Disease Undergoing Elective Cardiac Surgery Using the Heart-lung-machine
This clinical study investigates the safety and potential effectiveness of the investigational drug SP16 in preventing acute kidney injury in patients with pre-existing chronic kidney disease who are undergoing cardiac surgery…
- Trial name
- EASE-AKI (NCT07661940)
- Testing
- SP16-3M
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Ischemic Heart Disease
Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease
Assess the safety and effectiveness of stem cell application with regard to improvement in regional myocardial function in patients receiving Trans-Myocardial Laser Revascularization (TMR) and stem cells.
- Trial name
- NCT03043742
- Testing
- Bone Marrow Derived Autologous CD133+ Selected Cell Product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Michael Sekela
Chronic Stable Angina, PTCA
Myocardial Damage and Music Study
MYDA-MUSIC study is a randomized, double blind (operator and analyst) study performed in San Filippo Neri Hospital, Roma, Italy and in Di Venere Hospital, Bari, Italy. The planned study duration is 12 months.
- Trial name
- MYDA-MUSIC (NCT03507361)
- Testing
- HRV-BASED MUSIC
- Where
- Italy
- Volunteers
- 443 people
- Sponsor
- San Filippo Neri General Hospital
Chronic Heart Failure
Collaborative Care to Alleviate Symptoms and Adjust to Illness in Chronic Heart Failure (CASA) Trial
Chronic heart failure is an important public health problem as it is a leading cause of disability, hospitalization, death, and costs.
- Trial name
- CASA (NCT01739686)
- Testing
- CASA Intervention
- Where
- 3 sites in United States
- Volunteers
- 317 people
- Sponsor
- Denver Research Institute
Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure
Vericiguat and Reverse Remodeling Indices in Heart Failure
The goal of this clinical trial is to investigate how vericiguat benefits adults with stable heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy.
- Trial name
- VERI-PATH (NCT07405944)
- Testing
- Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT)
- Where
- 4 sites in Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana