Clinical trials: Chronic Heart Disorder
Iron Deficiency, Chronic Heart Failure
A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency
The purpose of this study is to determine, relative to placebo, the effect of iron repletion therapy using intravenous (IV) ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency.
- Trial name
- CONFIRM-HF (NCT01453608)
- Testing
- Ferinject (ferric carboxymaltose)
- Where
- 2 sites in Poland, Russia
- Volunteers
- 304 people
- Sponsor
- Vifor Pharma
Chronic Chagas Disease
Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas Disease
Chagas Disease, caused by the parasite Trypanosoma cruzi afflicts 7 million people in Latin America, and due to migration, abroad. The diagnosis lies in clinical suspicion and serologic detection of antibodies.
- Trial name
- ATOCHA (NCT04984616)
- Testing
- 40 mg Atorvastatin/day for 120 days P.O., Atorvastatin 80
- Where
- 4 sites in Chile
- Volunteers
- 300 people
- Sponsor
- Juan D. Maya
End Stage Renal Disease, Depression
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes
The objective of this study is to determine the effect of music therapy during dialysis on: depression, anxiety, quality of life, blood pressure, heart rate, medication compliance, compliance with dialysis treatment, number of…
- Conditions
- End Stage Renal Disease, Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT03925168
- Testing
- Music therapy
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Tulane University
Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Chronic Ischemic Heart Disease
This study was designed to test the hypothesis that direct injection of bone-marrow cells in the heart may increase the number of blood vessels, ameliorating the heart's performance, and relieving patients from symptoms like…
- Trial name
- NCT00362388
- Testing
- Intramyocardial injection of autologous bone marrow cells
- Where
- 6 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Ministry of Health, Brazil
SGLT2 Inhibitiors Remodeling Effect, Chronic Heart Disease
Effect of Sodium Glucose Cotransporter 2 Inhibitiors on Left Ventricular Remodeling Among Diabetic and Non Diabetic Patients With Chronic Heart Failure
To evaluate the efficacy of SGLT2 inhibitors on left ventricular global longitudinal strain and diastology parameters among diabetic and non-diabetic patients with chronic heart failure
- Trial name
- NCT06137430
- Testing
- Sodium-glucose cotransporter 2 inhibitor
- Volunteers
- 98 people
- Sponsor
- Assiut University
Heart Failure
The Role of Bioimpedance Analysis in Patients With Chronic Heart Failure and Systolic Ventricular Dysfunction
Heart failure (HF) represents a major problem in today's health care landscape and is expected to grow in the next years due to an aging population and improved treatments.
- Trial name
- NCT05631275
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Acute Myocardial Infarction
Hair Cortisol and Testosterone Levels in Patients With and Without Acute Myocardial Infarction(MI)
The purpose of this study is to determine whether hair levels of cortisol and testosterone are elevated in patients with acute MI compared to controls.
- Trial name
- NCT01144065
- Testing
- Hair sampling for the measurement of cortisol and testosterone
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Meir Medical Center
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Heart Failure
The Effects of Neuraminidase Inhibitor Oseltamivir in Patients With Chronic Heart Failure
Heart failure (HF) is a complex syndrome with increasing incidence and high rates of mortality and hospitalization. Although inhibitors of angiotensin converting enzyme (ACE), β-blockers and aldosterone-receptor blockers have…
- Trial name
- NCT05008679
- Testing
- Oseltamivir
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Tongji Hospital
Congestive Heart Failure
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure
The purpose of this study is to determine if Coreg CR is as effective as Coreg IR in improving heart function in subjects with stable chronic heart failure.
- Trial name
- COMPARE (NCT00323037)
- Testing
- carvedilol controlled release, carvedilol immediate release
- Where
- 75 sites in United States
- Volunteers
- 318 people
- Sponsor
- CTI-1, LLC
Atrial Fibrillation (AF), Chronic Lymphocytic Leukemia
Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy
This study looks at how often atrial fibrillation (AF), an irregular heart rhythm, occurs in people with certain blood cancers who are starting a type of cancer medicine called a Bruton's tyrosine kinase inhibitor (BTKI).
- Conditions
- Atrial Fibrillation (AF), Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia, Mantle Cell Lymphoma
- Trial name
- NCT07711327
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Tina Baykaner
Type 1 Diabetes, T1D Heart Failure
Precision T1D Platform - New Therapies for Cardio-Renal Complications
Breakthrough T1D has awarded support for a joint University of Michigan-Oregon Health \& Science University Center of Excellence (CoE) to address cardio-renal complications in T1D.
- Conditions
- Type 1 Diabetes, T1D Heart Failure, Cardio-renal Vascular Function and Failure, Diabetic Chronic Kidney Disease
- Trial name
- NCT07594145
- Testing
- Finerenone, Sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Oregon Health and Science University
Congestive Heart Failure, Chronic Heart Failure
Significance of Impedance Cardiography and Early Repolarization Pattern in ECG in Congestive Heart Failure
Congestive heart failure (CHF) is a disorder of the heart when structural or functional heart disease impairs the heart's ability to work properly.
- Conditions
- Congestive Heart Failure, Chronic Heart Failure, Right Ventricular Failure, Heart Failure
- Trial name
- SICERE-CHF (NCT05480345)
- Testing
- Impedance cardiography
- Where
- Lithuania
- Volunteers
- 301 people
- Sponsor
- Lithuanian University of Health Sciences
CKD - Chronic Kidney Disease, Heart Failure Preserved Ejection Fraction
Cardiovascular and Renal Endpoints With Flozins - an Observational Prospective Study in CKD HFpEF Patients
The main aim of this study is to holistically assess the cardiovascular and renal outcomes in HFpEF CKD patients with and without SGLT2 inhibition, with focus on the endothelial disfunction, MACE and mortality using clinical…
- Conditions
- CKD - Chronic Kidney Disease, Heart Failure Preserved Ejection Fraction, SGLT2 Inhibitors, Diabetes (DM)
- Trial name
- CARE FOR CKD H (NCT07237451)
- Testing
- Arterial stiffness, Echocardiography, Biomarkers determination
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Acute Kidney Injury, Chronic Kidney Disease, Stage 3
The Association Between the Duration of Acute Kidney Injury and New-onset Chronic Kidney Disease After Cardiac or Thoracic Aortic Surgery
The investigators aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Stage 3, Chronic Kidney Disease, Stage 5, Cardiac Surgery
- Trial name
- NCT04172103
- Where
- South Korea
- Volunteers
- 2,009 people
- Sponsor
- Seoul National University Hospital
Chronic Renal Disease, Chronic Renal Insufficiency
2D-speckle Tracking in Pediatric Renal Chronic Disease
The SPECKLE- KIDNEY-PED is a multicentre observational controlled trial aiming to evaluate the 2D-Speckle tracking in a population of 85 patients aged from 6 to 17 years old with a chronic renal disease and to compare the results…
- Conditions
- Chronic Renal Disease, Chronic Renal Insufficiency, Congenital Heart Disease
- Trial name
- SPECKLEKIDNEY (NCT04897672)
- Testing
- Observational study
- Where
- France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Heart Failure, Frailty
CR: Developing an Intervention to Improve Acceptance of Referral in HF
Background: There are proven benefits to people with chronic heart failure (CHF) participating in a cardiac rehabilitation (CR) programme, however uptake remains disappointingly low.
- Trial name
- CREATE-HF (NCT04276675)
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Leicester
Sudden Cardiac Death, End Stage Renal Disease
T-Wave Alternans in Dialysis Patients
Sudden cardiac death due to arrhythmia is the leading cause of death in end-stage renal disease (ESRD) patients treated with hemodialysis (HD).
- Trial name
- NCT00621426
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Chronic Kidney Failure, Inflammation
Vascular Calcification's Risk Factors in Haemodialysis Patients
A not randomized , cross sectional study will be done to determine the possible association of coronary artery calcification (CAC) score assessed by multirow spiral computed tomography (MSCT) with specific and non specific uremic…
- Conditions
- Chronic Kidney Failure, Inflammation, Vascular Calcification
- Trial name
- NCT00694824
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Coronary Artery Disease, Angina Pectoris
Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI)
This study will evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in chronic angina subjects with incomplete revascularization post-percutaneous coronary intervention (PCI…
- Trial name
- RIVER-PCI (NCT01442038)
- Testing
- Ranolazine
- Where
- 218 sites in United States, Austria and 13 more
- Volunteers
- 2,651 people
- Sponsor
- Gilead Sciences