Clinical trials: Chronic Heart Failure
Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF)
Clinical Trials for Elderly Patients With Multiple Disease
The CHROMED project focuses its investigation on the applicability of an integrated solution for a pathological condition which: a) is very prevalent in ageing patients and b) severely impairs quality of life: COPD with other…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF), Sleep Disordered Breathing (SDB)
- Trial name
- CHROMED (NCT01960907)
- Testing
- CHROMED monitoring system
- Where
- 6 sites in Estonia, Slovenia and 3 more
- Volunteers
- 312 people
- Sponsor
- Restech Srl
Congestive Heart Failure, Ischemic Cardiomyopathy
AutoLogous Human CArdiac-Derived Stem Cell to Treat Ischemic cArdiomyopathy (ALCADIA)
The aim of this study is to evaluate the safety and efficacy on the transplantation of autologous human cardiac-derived stem cells (hCSCs) with the controlled release of basic fibroblast growth factor (bFGF) to severe refractory…
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Ventricular Dysfunction
- Trial name
- ALCADIA (NCT00981006)
- Testing
- human cardiac stem cells
- Where
- 2 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Naofumi Takehara
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Cardiomyopathy, Coronary Artery Disease
Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly
The overall aim of this trial is to study the safety and efficacy of ICD implantation as a primary prevention strategy of sudden cardiac death in patients 70 years and older.
- Conditions
- Cardiomyopathy, Coronary Artery Disease, Congestive Heart Failure, Myocardial Infarction
- Trial name
- I-70 (NCT02121158)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- VA Office of Research and Development
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
IVR-Enhanced Care Transition Support for Complex Patients
For complex medical patients, the transition from hospital to home-based care is a vulnerable period, placing the patient at high risk for adverse events.
- Trial name
- NCT01135381
- Testing
- IVR-Enhanced Care
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- University of Alabama at Birmingham
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Heart Failure with Reduced Ejection Fraction, Chronic Heart Failure
Efficacy of a Streamlined Heart Failure Optimization Protocol
The SHORT trial compares the current standard optimization protocol to a shortened protocol in a randomized control trial.
- Trial name
- SHORT (NCT05021419)
- Testing
- Streamlined protocol, Standard Protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Hyperkalemia
An Observational Prospective Cohort Study for Long-term Management of Hyperkalemia in Patients With Chronic Kidney Disease or Heart Failure
This prospective observational research will be conducted to assess the burden of hyperkalemia including treatment and disease burden of patients in a long-term continuous care from various aspects including adherence to the…
- Trial name
- HK registry (NCT05297409)
- Where
- 32 sites in Japan
- Volunteers
- 352 people
- Sponsor
- AstraZeneca
Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis
Hypoxemia in Maintenance Hemodialysis Patients
Previous research has shown that many patients with kidney failure undergoing chronic hemodialysis (HD) have a very low venous oxygen concentration, which may further decrease during dialysis treatments.
- Conditions
- Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis, Kidney Failure, Chronic
- Trial name
- NCT03045796
- Testing
- Oxygen Saturation measured by WristOx
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Coronary Disease, Cardiovascular Diseases
Cardiac and Renal Disease Study (CARDS)
To examine the epidemiology of renal disease and its relationship to cardiovascular disease.
- Conditions
- Coronary Disease, Cardiovascular Diseases, Cerebrovascular Accident, Heart Failure
- Trial name
- NCT00049907
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Bi-Ventricular Pacing in Patients With Atrial Fibrillation and Heart Failure (BIFF-Study)
Cardiac resynchronization therapy (CRT) is used to treat dilated heart failure with discoordinate contraction. Dyssynchrony typically stems from electrical delay leading to mechanical delay between the septal and lateral walls.
- Trial name
- BIFF (NCT00457834)
- Testing
- InSync III
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Umeå University
Heart Failure
Post Marketing Surveillance (PMS) of JARDIANCE in Chronic Heart Failure (CHF)
Study objective is to investigate the safety and effectiveness of long-term daily use of JARDIANCE® Tablets in patients with chronic heart failure (CHF) under real-world use.
- Trial name
- NCT05262764
- Testing
- JARDIANCE®
- Where
- Japan
- Volunteers
- 1,200 people
- Sponsor
- Boehringer Ingelheim
COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive
COVID-19, Patients' Evolution and the Influence of the Pandemic on Health Care and Outcomes in Chronic Diseases
Objectives: 1.- To evaluate the changes in health care and use of services in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD), heart failure and major depression between 2017-2019 and the years…
- Conditions
- COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Depressive Symptoms
- Trial name
- NCT05168722
- Testing
- No interventions
- Where
- 5 sites in Spain
- Volunteers
- 2,220 people
- Sponsor
- Hospital Galdakao-Usansolo
Chronic Systolic Heart Failure
Evaluation of the Effect of Injectable Neucardin on Cardiac Function and Reversal Ventricular Remodeling in Patients With Chronic Systolic Heart Failure
A multicenter, randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the effect of recombinant human Neuregulin-1 for injection on cardiac function and reverse ventricular remodeling in male patients…
- Trial name
- NCT05949801
- Testing
- Neucardin
- Where
- 103 sites in China
- Volunteers
- 202 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Dyspnea
Trial of a Breathlessness Intervention Service for Intractable Breathlessness
The aim of this study is to evaluate the impact of a Breathlessness Intervention Service (BIS) on the quality of life of patients and families affected by intractable breathlessness.
- Trial name
- NCT00678405
- Testing
- Breathlessness Intervention Service, Best supportive care (Standard Care)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Heart Failure
Oral Iron Therapy in Chronic Heart Failure Patients
This study is design to evaluate the effectiveness of oral iron therapy in patients with heart failure and identify the central and peripheral mechanisms involved in the improvement of functional capacity after intervention.
- Trial name
- NCT02698046
- Testing
- Ferrous sulfate
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo
Hypertension and Chronic Heart Failure
Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.
The purpose of this study is to to assess the safety and tolerability of BIA 5 1058 after single and multiple oral doses
- Trial name
- NCT02151994
- Testing
- BIA 5-1058
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Chronic Heart Failure, Atrial Fibrillation
The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients.
To examine the effects of heart rate reduction on exercise capacity in control subjects and patients with chronic heart failure.
- Conditions
- Chronic Heart Failure, Atrial Fibrillation, Arrhythmia, Sinus
- Trial name
- TREPPE (NCT02247245)
- Testing
- Ivabradine, Atrial fibrillation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Leeds
Nephrogenic Systemic Fibrosis, Renal Failure
Nephrogenic Systemic Fibrosis With Gadollinum
Recently there is increasing reports of NEPHROGENIIC SYSTEMIC FIBROSIS(NSF) in patients with severe renal failure mainly in patients under dialysis in whom gadollinum is being used.
- Trial name
- NSF (NCT01359345)
- Testing
- gadollinum
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Imam Khomeini Hospital