Clinical trials: Chronic Hemodialysis Patients, active
Chronic Kidney Disease, Stage 5, Sarcopenia
Effects of Intradialytic Exercise on Muscle Oxygenation and Dialysis Adequacy
This randomized controlled trial will evaluate the effects of a 12-week intradialytic combined exercise program, consisting of aerobic and resistance training, in patients with stage 5 chronic kidney disease receiving maintenance…
- Trial name
- NCT07151742
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
End Stage Renal Disease (ESRD)
To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
The goal of this clinical trial is to compare the number of catheter-free days (CFD) and the rate and severity of any dialysis access-related infections between the ATEV and AVF groups over 12 months in patients with end-stage…
- Trial name
- NCT05908084
- Testing
- Acellular Tissue Engineered Vessel (ATEV), AVF
- Where
- 32 sites in United States
- Volunteers
- 121 people
- Sponsor
- Humacyte, Inc.
Staphylococcus Aureus
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis…
- Trial name
- PEAK (NCT06749457)
- Testing
- AZD7760
- Where
- 40 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertension in Dialysis Patients
Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels).
- Trial name
- NCT07231900
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Assaf-Harofeh Medical Center
Chronic Kidney Disease Requiring Hemodialysis
Effect of Zinc Supplementation on Hyperhomocysteinemia Compared to Folic Acid in CKD Patient on Hemodialysis
Hyperhomocysteinemia is a well-recognized risk factor for accelerated cardiovascular events in hemodialysis patients. Hyperhomocysteinemia is common in individuals with chronic kidney disease (CKD).
- Trial name
- CKD (NCT06847139)
- Testing
- Zinc Sulfate 50 Mg Tab, Folic Acid 5 Mg Oral Tablet
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Chittagong Medical College
Intradialytic Hypotension
Effect of Dialysate Cooling Versus Sodium Profiling in Management of Intradialytic Hypotension Among Chronic Hemodialysis Patients
Chronic kidney disease (CKD) is a worldwide public health issue. Dialysis patients have a tenfold greater relative risk of cardiovascular death than the general population.
- Trial name
- NCT06890195
- Testing
- dialysate cooling, standard dialysate temperature
- Volunteers
- 106 people
- Sponsor
- Assiut University
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
End Stage Renal Disease
Safety and Efficacy of Empagliflozin in Hemodialysis
A 12-week, phase II, randomized, double-blind, placebo-controlled, multi-center study to assess the safety, tolerability, and preliminary efficacy of empagliflozin versus placebo among patients initiating hemodialysis (n=60) for…
- Trial name
- SEED (NCT05786443)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Carcinoma, Renal Cell
Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma
A phase I/II, open-label, study to determine the safety and preliminary efficacy of orellanine in patients with metastatic clear-cell or papillary renal carcinoma who have failed standard-of-care therapy.
- Trial name
- NCT05287945
- Testing
- Orellanine
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 75 people
- Sponsor
- Oncorena AB
Kidney Disease, Chronc Kidney Disease Stage 5
The Effect of Patient Empowerment Learning (With AI) About Itching in Hemodylasis Patients.
This study investigates whether artificial intelligence-supported patient education can reduce itching and improve patient empowerment in individuals with chronic kidney disease undergoing hemodialysis.
- Conditions
- Kidney Disease, Chronc Kidney Disease Stage 5, Chronic Kidney Disease
- Trial name
- NCT07740083
- Testing
- Artificial Intelligence-Supported Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Izmir Tinaztepe University
Chronic Kidney Disease on Hemodialysis, Meals
Restorative and Supportive Meals at HomeCare
The pilot intervention study is designed to evaluate the feasibility of implementing a tailored medical nutrition therapy (MNT) meal-delivery for 25 elderly, low-income food insecure patients with end-stage kidney disease…
- Conditions
- Chronic Kidney Disease on Hemodialysis, Meals, Medical Nutrition Therapy
- Trial name
- RASA (NCT07283926)
- Testing
- Medical Nutrition Therapy + Meal Delivery
- Where
- 4 sites in Malaysia
- Volunteers
- 25 people
- Sponsor
- Universiti Putra Malaysia
Malnutitrion, Chronic Kidney Disease on Hemodialysis
Nutritional Status in Patients With Chronic Kidney Disease Receiving 7.2% Amino Acids During Hemodialysis
Malnutrition and anemia are common among people with chronic kidney disease who receive maintenance hemodialysis. These conditions may worsen health outcomes and quality of life.
- Conditions
- Malnutitrion, Chronic Kidney Disease on Hemodialysis, Anemia (Diagnosis)
- Trial name
- NCT07881627
- Where
- Indonesia
- Volunteers
- 90 people
- Sponsor
- PT Otsuka Indonesia
Chronic Kidney Diseases
Intradialisis Physical Exercise in Quality of Life and Health
Evaluate the effectiveness of different modalities of physical exercise about clinical health indicators and quality of life of patients with chronic kidney disease undergoing hemodialysis.
- Trial name
- EJERINTRA (NCT05207527)
- Testing
- cardiovascular exercise, Muscle strength, Mixed
- Volunteers
- 120 people
- Sponsor
- Universidad del Rosario
Sarcopenia, ESRD (End Stage Renal Disease)
Serum Insulin-like Growth Factor-1 to Albumin Ratio as a Biomarker for Sarcopenia Severity in End-Stage Renal Disease Patients on Hemodialysis
Sarcopenia is a prevalent and serious complication among patients with End-Stage Renal Disease (ESRD) receiving maintenance dialysis, characterized by progressive loss of skeletal muscle mass, strength, and physical function.
- Trial name
- NCT07586956
- Volunteers
- 110 people
- Sponsor
- Sohag University
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Hemodialysis, Renal Failure , Chronic
Comparative Study Between Leg Massage and Vibration on Cramps and Comfort for Patients Undergoing Hemodialysis
This planned randomized controlled trial will enroll 164 patients undergoing hemodialysis to compare the effectiveness of leg massage versus vibration therapy on muscle cramps and patient comfort.
- Trial name
- NCT07777354
- Testing
- massage, vibration
- Volunteers
- 160 people
- Sponsor
- University of Baghdad
Kidney Failure, Chronic, Hyperphosphatemia
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested.
- Trial name
- PHOSPHATE (NCT03573089)
- Testing
- Liberal phosphate target, Intensive phosphate target
- Where
- 126 sites in Australia, Brazil and 7 more
- Volunteers
- 3,600 people
- Sponsor
- The University of Queensland
Metabolic Disorder, End Stage Renal Disease
Rheopheresis as Adjuvant Treatment of Calciphylaxis
The investigators propose to set up a prospective randomized controlled trial to control the security and assess the efficacy of adjuvant treatment by rheopheresis in necrotizing-ulcered calciphylaxis in the hemodialysis…
- Conditions
- Metabolic Disorder, End Stage Renal Disease, Rare Diseases
- Trial name
- RHEO-CAL (NCT04654000)
- Testing
- Rheopheresis procedure
- Where
- 29 sites in France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Lille
Supportive Care, Exercise Adaptations
Intradialytic Exercise and Cognitive Function
Exercise training may improve global and domain-specific cognitive function, mental health, psychological well-being, dialysis efficacy, and health-related quality of life in people with end-stage kidney disease receiving…
- Conditions
- Supportive Care, Exercise Adaptations, Exercise Training Therapy, Clinical Exercise
- Trial name
- EXCOG-HD (NCT07780175)
- Testing
- Resistance Training, Aerobic training, Combination Training
- Where
- Cyprus
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Kidney Failure, Chronic Therapy; Hemodialysis
Web-based Advance Care Planning Intervention for Patients With Kidney Failure on Dialysis: Pilot Testing of 'My Voice'
'My Voice' is a website intervention developed to enable advance care planning (ACP) conversations for patients with kidney disease on dialysis, educate patients on their illness, help identify their goals and preferences for EOL…
- Trial name
- NCT07309367
- Testing
- My Voice website intervention with patient and caregiver modules
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School