Clinical trials: Chronic Hepatic
Decompensated Cirrhosis, Cirrhotic Cardiomyopathy
Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival
Cirrhosis and portal hypertension are associated with a hyperdynamic circulation and decompensation events, including development of ascites, variceal bleeding, acute kidney injury, and susceptibility to infections.
- Conditions
- Decompensated Cirrhosis, Cirrhotic Cardiomyopathy, Cirrhosis, Liver, Left Ventricular Diastolic Dysfunction
- Trial name
- CIRROSTAT (NCT06431919)
- Testing
- Simvastatin 20mg, Carvedilol 3.125 mg
- Where
- India
- Volunteers
- 260 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Hepatitis C, Cirrhosis
Transient Elastography to Assess Liver Fibrosis and Portal Hypertension in HCV Cirrhotic Patients Treated With New Antiviral Drugs (SPLEEN-C)
The purpose of this study is to evaluate the effects of sustained virological response in liver and spleen stiffness in patients with HCV compensated advanced chronic liver disease treated with new all oral antiviral drugs in…
- Conditions
- Chronic Hepatitis C, Cirrhosis, Portal Hypertension
- Trial name
- SPLEEN-C (NCT02439567)
- Testing
- Fibroscan: Liver and Spleen elastography
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Liver Diseases, Liver Transplant; Complications
Prognostic Factors After Liver Transplantation
The study retrospectively reviewed the medical records of patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019.
- Trial name
- NCT05018741
- Testing
- liver transplantation
- Volunteers
- 600 people
- Sponsor
- Changhua Christian Hospital
Acute-On-Chronic Liver Failure, Acute Liver Failure
The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) refers to a liver failure syndrome in which some patients with chronic liver disease with relatively stable liver function suffer from acute liver decompensation and liver failure due to the…
- Trial name
- NCT05940610
- Testing
- MSC-EVs
- Where
- China
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Chronic Liver Disease
Study to Evaluate the Efficacy and Safety of DWJ1464 in Patients with Chronic Liver Disease
This study aims to assess the effect of DWJ1464 on improvement of liver function in patients with Chronic liver disease. Patients with Chronic liver disease aged 19 years or over will participate in the study.
- Trial name
- NCT06272630
- Testing
- DWJ1464
- Where
- South Korea
- Volunteers
- 263 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Acute-On-Chronic Liver Failure
Usefulness of the Variation of the CLIF-C ACLF Score in Patients With Acute on Chronic Liver Failure
Patients with Acute on Chronic Liver Failure (ACLF) have high short-term mortality. The use of a severity score could define the patient's prognosis and would help determine in whom the treatment is effective or futile.
- Trial name
- ARIHAC (NCT04186572)
- Volunteers
- 30 people
- Sponsor
- Hospital El Cruce
Liver Failure
Prognosis Scoring System for Acute-on-Chronic Liver Failure
This research is to establish a simple and practical system to predict the prognosis of sever hepatitis B.Seven factors (level of serum total bilirubin, prothrombin time, severity of hepatic encephalopathy, hepatorenal…
- Trial name
- NCT01961440
- Volunteers
- 1,000 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute on Chronic Liver Failure
Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients
The First-In-Man study is a multi-centre, randomised, controlled, study to generate data for the evaluation of safety and performance of DIALIVE Liver Dialysis Device in 24 evaluable patients with Acute on Chronic Liver Failure…
- Trial name
- DIALIVE _ACLF (NCT03065699)
- Testing
- DIALIVE Liver Dialysis Device
- Where
- 12 sites in Austria, Belgium and 6 more
- Volunteers
- 30 people
- Sponsor
- Yaqrit Ltd
Hypercholesterolemia
Pravastatin Efficacy and Safety Trial in Hypercholesterolemic Patients With Chronic Liver Disease
To determine in hypercholesterolemic subjects with chronic, well-compensated liver disease, the percent change from baseline to Week 12 in serum LDL-C of pravastatin 80 mg compared to placebo.
- Trial name
- NCT00529178
- Testing
- Pravastatin
- Volunteers
- 232 people
- Sponsor
- Bristol-Myers Squibb
Hepatic Encephalopathy, Acute Liver Failure
Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy
Hepatic encephalopathy is a frequent complication of both acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) and could be responsible among other neurological complications of residual impairment after liver…
- Conditions
- Hepatic Encephalopathy, Acute Liver Failure, Acute on Chronic Liver Failure
- Trial name
- EH-CASIMIR (NCT05772585)
- Testing
- Blood collection
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute-On-Chronic Liver Failure
Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients
Document Name: This Trial is a Phase II Clinical Study.docx Document Content: This trial is a Phase II clinical study, conducted in two stages: Phase IIa: A sentinel, single-arm design will be employed.
- Trial name
- NCT06916585
- Testing
- AS1501 for injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shenzhen Third People's Hospital
Acute on Chronic Liver Failure
Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acute on Chronic Liver Failure.
Data for stool microbiome will be collected for all the chronic hepatitis B subjects (pre cirrhotic,compensated,decompensated and reactivation).
- Trial name
- NCT02689245
- Testing
- Tenofovir, Fecal Microbiota Transplantation (FMT)
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
End Stage Liver Disease, Hepatitis C
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
The purpose of this study is to compare three treatment regimens in patients who have received a liver transplant for end-stage liver disease caused by Chronic Hepatitis C infection.
- Trial name
- NCT00163657
- Testing
- Daclizumub, Tacrolimus, Cyclosporine
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Baylor Research Institute
Portal Hypertension, Chronic Liver Disease
Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)
The aim of this diagnostic study is to evaluate the efficacy of ARFI imaging (a specific type of ultrasound) in assessing the pressure of the portal vein (the major vein passing through the liver) and the amount of liver fibrosis…
- Trial name
- NCT01644656
- Testing
- ARFI ultrasound
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- VA Connecticut Healthcare System
Acute-On-Chronic Liver Failure
Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure
Mesenchymal stem cells (MSC) has been reported to improved outcomes of acute-on-chronic liver failure(ACLF). More randomization controlled studies are needed to confirm the effect of MSC treatment for ACLF.
- Trial name
- NCT03668171
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Chronic Liver Disease
Study to Compare the Efficacy & Safety of Ursoplus Capsules vs. UDCA vs. Placebo Among Chronic Liver Disease Patients
This study aims to compare the efficacy \& safety of Ursoplus® capsules (UDCA 250mg \& Silymarin 140mg) versus UDCA alone versus Placebo among Compensated Chronic Liver Diseased Patients
- Trial name
- URSO-003 (NCT05849558)
- Testing
- Ursoplus, UDCA 250mg
- Where
- Egypt
- Volunteers
- 297 people
- Sponsor
- MinaPharm Pharmaceuticals
Lactic Acidosis
Lactic Acidosis During Entecavir(ETV)Treatment
The purpose of this study is to investigate whether entecavir treatment increases the incidence of lactic acidosis compared to another nucleoside/nucleotide reverse transcriptase inhibitors (NRTI), lamivudine, and/or no NRTI…
- Trial name
- ETV (NCT01354652)
- Testing
- entecavir, lamivudine
- Volunteers
- 5 people
- Sponsor
- Asan Medical Center
Chronic Hepatitis B, Hepatic Steatosis
Liver Status and Presence of MASLD/MASH in Patients With Chronic Hepatitis B
The aim of the study was to evaluate the consistency between liver biopsy and Liver Stiffness Measurement (LSM) for fibrosis and controlled attenuation parameter (CAP) for steatosis in FibroScan® in patients with chronic…
- Trial name
- Faraday (NCT06573190)
- Testing
- Transient elastography, Tenofovir Disoproxil Fumarate
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yaşar Bayındır, MD