Clinical trials: Chronic Hepatic
Chronic Hepatitis C
A Phase 1 Study to Evaluate the Pharmacokinetics of GS-5816 in Subjects With Normal Hepatic Function and Moderate or Severe Hepatic Impairment
This is a Phase 1 Open-Label, Parallel-Group, Single-Dose Study to evaluate the Pharmacokinetics of GS-5816 in subjects with normal hepatic function and moderate or severe hepatic impairment.
- Trial name
- NCT01817985
- Testing
- GS-5816
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Liver Fibrosis
Anticoagulation in Liver Fibrosis in Patients With Hepatitis C Virus Infection
Patients who have been treated for hepatitis C virus (HCV) infection who have failed to respond to anti-viral treatment are often concerned about their ongoing liver disease and are therefore looking for alternative treatments…
- Trial name
- NCT00180674
- Testing
- Warfarin
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Imperial College London
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Portal Hypertension
Non-Invasive Portal and Hepatic Vein Pressure Estimation
Background Portal hypertension (PH) is a spectrum of complications of end-stage liver disease (ESLD) and cirrhosis, with severe manifestations including ascites and gastroesophageal varices.
- Trial name
- NONEEDLES (NCT06210178)
- Testing
- Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Healthy Adult Participants, Liver Disease Chronic
Validation of Different Methods for HepQuant DuO® Blood Sample Collection
This is a study to see the agreement of blood samples collected through different means and tube types for the HepQuant DuO Test.
- Trial name
- NCT07473817
- Testing
- HepQuant DuO Test
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HepQuant, LLC
Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma
Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function
This phase I trial is studying the side effects and best dose of sorafenib in treating patients with metastatic or unresectable solid tumors, multiple myeloma, or non-Hodgkin's lymphoma with or without impaired liver or kidney…
- Conditions
- Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma
- Trial name
- NCT00118170
- Testing
- sorafenib tosylate, pharmacological study
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Acute-On-Chronic Liver Failure
Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University Hospitals
ACLF is a distinct syndrome that is different from chronic progressive hepatic decompensation. In most cases of ACLF, patients present initially with clinical manifestations of a decompensating event, usually renal impairment…
- Trial name
- NCT06142968
- Testing
- laboratory tests
- Volunteers
- 96 people
- Sponsor
- Assiut University
Chronic Liver Disease, HepatoCellular Carcinoma
Proof of Concept Study Concerning Efficacy of P03277 MR Imaging in HCC Diagnosis
This study is an exploratory study aiming to collect data about diagnosis efficacy (sensitivity and specificity) of P03277 triphasic liver imaging for HCC in subjects with suspected small nodules and chronic liver disease.
- Trial name
- NCT02973516
- Testing
- P03277 at 0.1 mmol/kg, P03277 at 0.05 mmol/kg
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- Guerbet
Hepatic and Hepatobiliary Disorders
Essentiale® Paste in Patients With Gastrointestinal Symptoms in Acute or Chronic Liver Diseases
Primary Objective: To assess safety of Phosphatidylcholine paste 600 mg (ESSENTIALE® paste) oral 3 times a day for 12 weeks in patients with gastrointestinal symptoms in acute and chronic liver diseases.
- Trial name
- EPLID (NCT02517385)
- Testing
- Phosphatidylcholine
- Where
- Russia
- Volunteers
- 147 people
- Sponsor
- Sanofi
Acute-On-Chronic Liver Failure
Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure
Monitoring and Assessment: Transient Elastography will be performed in morning hours using the FibroScan apparatus (Echosens), which consists of a 5-MHz ultrasound transducer probe mounted on the axis of a vibrator.
- Trial name
- NCT04983108
- Testing
- No Intervention
- Where
- India
- Volunteers
- 216 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Liver Injury, Mindray Hepatus 9 Ultrasound Diagnostic System
Multicenter Clinical Study on Noninvasive Assessment of Hepatic Steatosis and Fibrosis Using Visual Transient Elastography
Using liver biopsy as the gold standard, this study will conduct visual transient elastography (ViTE) examinations using Mindray Hepatus 9 ultrasound diagnostic system in patients with liver injury to evaluate the diagnostic…
- Trial name
- NCT07128108
- Testing
- Visual Transient Elastography (ViTE) Examination
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute-On-Chronic Liver Failure
To Optimize Therapeutic Procedures of DPMAS in ACLF Patients: a Prospective, Sigle Arm and Multicenter Study
Acute-on-chronic liver failure (ACLF) is a life-threaten syndrome carrying high-short-term mortality raging 40% to 60% within 90 days in patients with chronic liver disease.
- Trial name
- NCT06377774
- Testing
- No intervention in this study
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Liver Diseases, Spleen Stiffness
Clinical Trial to Evaluate the Effectiveness of Liver Shear Wave Quantization Detector Spleen Stiffness Value in the Diagnosis of Esophageal Varices
Esophageal variceal bleeding is one of the serious and life-threatening complications of chronic liver disease (CLD). Studies have shown that the prevalence of esophageal varices (EV) in patients with liver cirrhosis is about…
- Conditions
- Chronic Liver Diseases, Spleen Stiffness, Esophageal Varices, Diagnostic Performance Study
- Trial name
- NCT07753577
- Volunteers
- 246 people
- Sponsor
- Beijing Friendship Hospital
Liver Disease (Alcoholic or Not)
Evaluation of the Involvement of the Intestinal Microbiota and Choline Deficiency in the Severity of Chronic Liver Disease Explored by Analyzing Collection of Biological Samples (MICRONACH)
Chronic liver diseases are common and the two main causes in France are NAFLD (No Alcoholic Fatty Liver Disease Nonalcoholic) and ALD (alcoholic liver disease).
- Trial name
- MICRONACH (NCT02650115)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Stem Cells, Adult Stem Cells
Safety Study of Stemchymal® in Acute Liver Failure
To investigate the safety of Stemchymal® via intravenous (IV) infusion in acute liver failure (ALF) and acute on chronic liver failure (ACLF) patients.
- Conditions
- Stem Cells, Adult Stem Cells, Acute Liver Failure, Acute-On-Chronic Liver Failure
- Trial name
- ALF (NCT03629015)
- Testing
- Stemchymal®
- Where
- Taiwan
- Sponsor
- Steminent Biotherapeutics Inc.
Bariatric Surgery Candidate, Obesity, Morbid
Portal Hypetension and Bariatric Surgery (BARIAPORTAL)
The worldwide obesity epidemic has led to an increase in the proportion of patients with chronic liver disease due to non-alcoholic fatty liver disease (NAFLD) and in the prevalence of obesity in patients with cirrhosis of all…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Portal Hypertension
- Trial name
- BARIAPORTAL (NCT05653115)
- Testing
- Bariatric surgery
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Liver Diseases
Phase 2, Pharmacokinetics Study of Eltrombopag in Japanese Thrombocytopenic Subjects With Chronic Liver Disease
This is an open label, multi-centre, dose ranging study to assess efficacy, safety and pharmacokinetics of eltrombopag in thrombocytopenic subjects with chronic liver disease.
- Trial name
- NCT00861601
- Testing
- eltrombopag 12.5 milligrams (mg) tablet, eltrombopag 25 mg tablet
- Where
- 10 sites in Japan
- Volunteers
- 38 people
- Sponsor
- GlaxoSmithKline
Ischemia, Oxygen Deficiency
Magnetic Resonance Flow Measurements of Mesenteric Arteries and Veins and Portal Vein
To determine the difference in baseline MR flow measurements and post-prandial MR flow measurements between patients diagnosed with CGI and patients not diagnosed with CGI.
- Trial name
- NCT02875600
- Testing
- Nutri Drink
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Erasmus Medical Center
Acute on Chronic Liver Failure
Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
ACLF is defined differently in APASL,EASL and AASLD.APASL talks of reversibility in ACLF as per its definition and constitution of Homogenous population with ACLF.The definition of ACLF as per APASL is an acute hepatic insult…
- Trial name
- NCT06556472
- Testing
- Terlipressin, Norephrine
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Knee Instability
Interest of Additional Arthroscopic Portals in Diagnosis of Hidden Lesions of the Medial Meniscus in Pediatrics Knees With ACL Deficiency
Peroperatively observative study in pediatric orthopedic center in Lyon, France. 50 pediatric patients included in this study, to improve the diagnosis of hidden lesions of the medial meniscus associated with lesions of the…
- Trial name
- NCT02425995
- Testing
- Arthroscopic intercondylar and posteromedial portal
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon