Clinical trials: Chronic Hepatic
Chronic Hepatitis b, Liver Inflammation
Magnesium Isoglycyrrhizinate Followed by Diammonium Glycyrrhizinate and Combined With Entecavir in Chronic Hepatitis B
This study evaluates the addition of glycyrrhizin to entecavir in the treatment of patients with chronic hepatitis B in China. Half of participants will receive magnesium isoglycyrrhizinate followed by oral diammonium…
- Trial name
- MAGIC-101 (NCT03349008)
- Testing
- Entecavir, Magnesium Isoglycyrrhizinate, Diammonium Glycyrrhizinate
- Volunteers
- 480 people
- Sponsor
- Cttq
Porto-sinusoidal Vascular Liver Disorder, Liver Cirrhosis
Multiparametric Ultrasound for the Noninvasive Diagnosis of Porto-sinusoidal Vascular Liver Disorder
Porto-sinusoidal vascular disease (PSVD) is a rare clinical entity characterized by significant portal hypertension in the absence of cirrhosis on liver histology, which may or may not show specific alterations of the portal…
- Conditions
- Porto-sinusoidal Vascular Liver Disorder, Liver Cirrhosis, Portal Hypertension, Noncirrhotic, Portal Hypertension Related to Cirrhosis
- Trial name
- CEUS-PSVD (NCT07492862)
- Testing
- Evaluation of quantitative perfusion parameters at dynamic contrast-enhanced ultrasound through Vuebox Software
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatocellular Carcinoma
Contrast Enhanced Ultrasound (CEUS) in Atypical Liver Nodules in Patients With Chronic Liver Disease
The present study aims to investigate the role of CEUS in evaluating liver lesions with atypical characteristics on contrast-enhanced CT or MRI. All patients enrolled in the study underwent contrast-enhanced ultrasound.
- Trial name
- NCT05772403
- Testing
- CEUS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic
A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems
Pevonedistat is a medicine to treat people with blood cancers or solid tumors. The main aim of the study is to learn about the levels of pevonedistat in the blood of participants with blood cancers or solid tumors, who also have…
- Conditions
- Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute, Renal Insufficiency
- Trial name
- NCT03814005
- Testing
- Azacitidine, Pevonedistat
- Where
- 8 sites in United States, Spain
- Volunteers
- 17 people
- Sponsor
- Takeda
Thrombocytopenia Associated With Chronic Liver Disease
Phase 3 Study of rhTPO for Thrombocytopenia in Chronic Liver Disease Patients Undergoing Elective Invasive Procedures.
This is a global, multicenter, randomized, double-blind, placebo-controlled study using recombinant human thrombopoietin stimulating factor ( rhTPO) to treat adults with Chronic liver disease-related thrombocytopenia (CLDT).
- Trial name
- NCT07911800
- Testing
- rhTPO
- Where
- 2 sites in Georgia
- Volunteers
- 150 people
- Sponsor
- MIBIO PTE. LTD.
Acute on Chronic Liver Failure
Granulocyte Colony Stimulating Factor(G-CSF) Therapy for Patients With ACLF
The purpose of the study is to determine whether Granulocyte Colony Stimulating factor(G-CSF) therapy is effective in the treatment of patients with Acute on chronic liver failure(ACLF).
- Trial name
- NCT01036932
- Testing
- Granulocyte Colony Stimulating Factor, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Govind Ballabh Pant Hospital
Acute-On-Chronic Liver Failure
Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRT
ACLF and cirrhotic patient have deranged coagulation parameters and this coagulation parameters altered when this group of patients undergoing dialysis because of renal failure. this group of patients is also high risk of sepsis.
- Trial name
- NCT04960163
- Testing
- No intervention
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Patient Portals, Chronic Disease
A Theory-Based Patient Portal eLearning Program for Older Adults With Chronic Illnesses
The high prevalence of chronic illnesses is a serious public health problem in the U.S., and more than 70 million adults age ≥50 have at least one chronic illness.
- Conditions
- Patient Portals, Chronic Disease, Older Adults
- Trial name
- NCT03242070
- Testing
- Theory-based PP eLearning Program(T-PeP)
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Liver Disease Chronic, Thrombocytopenia
A Phase Ib Clinical Study for rhTPO in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease
The purpose of this study is to explore the multiple-dose regimen of recombinant human thrombopoietin (rhTPO) injection for the treatment of thrombocytopenia in patients with chronic liver disease.
- Trial name
- NCT05193201
- Testing
- recombinant human thrombopoietin injection
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Chronic Liver Disease
Evaluation of the Quality of Life in Patients Referred for Transjugular Intrahepatic Portosystemic Shunt
Patient with Advanced Chronic Liver Disease often present portal hypertension which may lead to bleading or ascites. One of the treatment of portal hypertension in these patients is the placement of a Transjugular Intrahepatic…
- Trial name
- TIPS (NCT05204251)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Hepatitis C, Hepatic Fibrosis
Prediction of Significant Hepatic Fibrosis in HCV Carriers With PNALT by SAPI- A Validation Study
The purpose of the study is to validate the diagnostic accuracy and reproducibility of SAPI to predict significant hepatic fibrosis in HCV patients with PNALT who are scheduled to receive combination therapy with pegylated…
- Trial name
- NCT00466271
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- National Taiwan University Hospital
COVID-19, Chronic Liver Failure
Evaluation of Long Haul COVID-19 and Vaccine Immunogenicity in Patients With Liver Disease
The project is essential to understand the impact of the COVID-19 pandemic in patients with Chronic Liver Disease (CLD). The impact has been felt due to direct risk of COVID infection in self, or in caregivers, lack of access to…
- Conditions
- COVID-19, Chronic Liver Failure, Cirrhosis, Liver, Portal Hypertension
- Trial name
- EvaLongCovid (NCT05107271)
- Testing
- COVID-19 serosurvey
- Where
- India
- Volunteers
- 252 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Liver Disease
Hepatic Venous Pressure Gradient and Platelet Activation in Chronic Liver Disease
Background: Thrombosis may be crucial in driving the progression of fibrosis in chronic liver disease (CLD). The potential role of platelets and platelet activation in this process is unclear.
- Trial name
- NCT02618798
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
COVID-19
Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease
To measure the frequency of persistent liver dysfunction (raised liver enzymes, serum albumin, prothrombin time, etc) in recovered COVID -19 patients.
- Trial name
- NCT04998214
- Testing
- liver function , prothrombin time , INR , US .
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Assiut University
Chronic Liver Disease
19Gauge Fine Needle Biopsy (FNB) Versus 22Gauge FNB for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB)
To determine the adequacy of EUS-LB using a 19G core needle compared to a 22G core needle in a prospective randomized study.
- Trial name
- NCT04806607
- Testing
- 19G FNB, 22G FNB
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Geisinger Clinic
Chronic Hepatitis C Infection
Assess the Antifibrotic Activity of Fuzheng Huayu in Chronic Hepatitis C Patients With Hepatic Fibrosis
Current treatment of chronic liver disease relies upon removing the primary insult to the liver (e.g., alcohol) or treating the underlying viral infection (HBV, HCV, etc.).
- Trial name
- NCT00854087
- Testing
- Fuzheng Huayu
- Where
- 8 sites in United States
- Volunteers
- 118 people
- Sponsor
- Tarek Hassanein
Depression, Chronic Liver Disease
Vitamin D Improves Depression in Liver Patients
This study evaluates the efficacy of vitamin D replacement therapy in reducing depressive symptoms in patients with chronic liver disease and vitamin D deficiency.
- Trial name
- CLDVitD (NCT02359266)
- Testing
- Vitamin D
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- Universität des Saarlandes
Liver Fibrosis
Prognosis Value of Transient Elastography and Non-invasive Markers of Fibrosis in Patients With Chronic Liver Disease
The aim of this prospective study was to compare the 5-year prognostic value of transient elastography (TE), FibroTest (FT), APRI , FIB-4, Lok, and Child-Pugh scores for predicting survival and complications of cirrhosis in…
- Trial name
- PVTE (NCT01241227)
- Where
- France
- Volunteers
- 1,830 people
- Sponsor
- Association HGE CHU Bordeaux Sud
Liver Fibrosis, Hepatic Fibrosis
A Trial of IDN-6556 in Post Orthotopic Liver Transplant for Chronic HCV
This is a double-blind, multicenter study involving patients with chronic HCV infection who had a liver transplantation; developed HCV-related liver fibrosis and/or incomplete cirrhosis; achieved a sustained virologic response…
- Conditions
- Liver Fibrosis, Hepatic Fibrosis, Liver Cirrhosis, Hepatic Cirrhosis
- Trial name
- POLT-HCV-SVR (NCT02138253)
- Testing
- IDN-6556
- Where
- 35 sites in United States
- Volunteers
- 64 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Acute Liver Failure, Acute-On-Chronic Liver Failure
Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients
This is a prospective, comparative, open label, phase 2b study designed to investigate the safety and efficacy of LifeLiver (an Extracorporeal Bio Artificial Liver).
- Trial name
- NCT03882346
- Testing
- LifeLiver
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- HLB Cell Co., Ltd.