Clinical trials: Chronic Hepatic
Chronic Liver Disease
Liver and Splenic Stiffness in Predicting Esophageal Varices Needing Treatment in MASLD Related Compensated Advanced Chronic Liver Disease.
Patients with chronic liver disease (CLD) are at risk of developing clinically significant portal hypertension (CSPH). In the Baveno VI consensus a new term "compensated advanced chronic liver disease (cACLD)'' has been proposed…
- Trial name
- NCT05044663
- Testing
- No intervention
- Where
- India
- Volunteers
- 325 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Liver Disease, Acute Derangement of Liver Function
Clinical Features and Natural History of Acute-on-Chronic Liver Failure in Korean Patients With Chronic Liver Disease
Chronic liver disease including liver cirrhosis is still associated with high mortality, although advancement of medical management and transplantation.
- Trial name
- NCT02650011
- Testing
- Acute deterioration of liver function
- Where
- South Korea
- Volunteers
- 1,520 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Acute on Chronic Liver Failure
Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)
SIRS in ACLF exacerbate adverse effects of ammonia - sarcopenia, infections, immune dysfunction, HE and organ dysfunction Persistent or incident hyperammonemia during first week of hospitalization in patients with ACLF is…
- Trial name
- NCT06808009
- Testing
- Lactulose, Rifaximin, Standard Medical treatment
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatic Encephalopathy
Correlation Between Serum Albumin Level and Severity of Hepatic Encephalopathy in Patients With Chronic Liver Disease in Sohag University Hospital
assess the correlation between serum albumin levels and the severity of hepatic encephalopathy in patients with chronic liver disease. assess the impact of albumin level on clinical course and outcomes of HE.
- Trial name
- NCT06953921
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Liver Disease Chronic, End Stage Liver DIsease
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
The goal of this clinical trial is to evaluate whether early integration of palliative care in the care of hospitalized patients with advanced liver disease (AdvLD) can improve patients' quality of life, physical symptoms, mood…
- Conditions
- Liver Disease Chronic, End Stage Liver DIsease, Cirrhosis, Cirrhosis, Liver
- Trial name
- LiverPAL (NCT05998330)
- Testing
- LiverPAL
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Massachusetts General Hospital
Drug Induced Liver Injury, Chronic Liver Disease
Efficacy of Plasmapheresis in Patients of Drug-Induced Liver Injury (DILI) With Underlying Chronic Liver Disease
DILI is an underdiagnosed and under appreciated causal or contributing factor to liver injury. DILI can mimics features of the entire spectrum of acute and chronic liver disease.
- Trial name
- NCT06797011
- Testing
- High volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Carcinoma, Hepatocellular, Cirrhosis
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver.
- Trial name
- PREMIUM (NCT05486572)
- Testing
- Abbreviated Magnetic Resonance Imaging with serum AFP, Abdominal Ultrasound Screening with serum AFP
- Where
- 34 sites in United States
- Volunteers
- 4,700 people
- Sponsor
- VA Office of Research and Development
Thrombocytopenia Associated With Liver Disease
Treatment of Thrombocytopenia in Patients With Chronic Liver DiseaseUndergoing an Elective Procedure
This is a global, multicenter, randomized, double-blind, placebo-controlled, parallel group study using avatrombopag to treat adults with thrombocytopenia associated with liver disease.
- Trial name
- NCT01972529
- Testing
- avatrombopag (lower baseline platelet count), avatrombopag (higher baseline platelet count)
- Where
- 109 sites in United States, Argentina and 18 more
- Volunteers
- 231 people
- Sponsor
- Eisai Inc.
Cirrhosis, Liver
Acute-On-Chronic Liver Failure In Cirrhotic Patients
Cirrhosis is a condition characterized by diffuse fibrosis, severe disruption of the intrahepatic arterial and venous flow, portal hypertension and, ultimately, liver cell failure.
- Trial name
- NCT04790435
- Where
- Egypt
- Volunteers
- 109 people
- Sponsor
- Sohag University
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04454424
- Testing
- BAY1817080, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Bayer
Renal Insufficiency, Kidney Diseases
A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
This is a multicenter, open-label, parallel-group study to evaluate INCB054707 in participants with varying levels of renal function or impairment.
- Trial name
- NCT05624710
- Testing
- INCB054707
- Where
- 4 sites in United States, Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Chronic Liver Disease and Cirrhosis
Different Regimens of Vitamin D in Treatment of Children With Chronic Liver Disease
The primary aim is to assess the efficacy of two different Vitamin D regimes in the treatment of vitamin D deficiency in children with chronic liver disease.
- Trial name
- NCT05717569
- Testing
- Vitamin D
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Portal Hypertension
Clinical,Endoscopic and Radiological Assessment of Portal Hypertension in Children With Chronic Liver Diseases
Portal hypertension is a significant cause of morbidity and mortality in children with chronic liver disease and portal vein obstruction.
- Trial name
- NCT06097715
- Testing
- upper gastrointestinal endoscopy, 1- Complete blood count 2- Coagulation profile
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hepatocellular Carcinoma, Chronic Liver Disease
Preoperative Oral Supplementation With Branched-Chain Amino Acids (BCAA) Improves Postoperative Quality of Life
The aims of this study are (1) to study the benefit of branched-chain amino acids enriched nutrient-mixture by analyzing a variety of clinical parameter, including laboratory data, the duration of hospitalization after the…
- Trial name
- KMS (NCT00945568)
- Testing
- Aminoleban EN
- Where
- 2 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Kochi University
Hepatitis C Virus, Chronic Liver Disease
Different PEG-interferon and Ribavirin Schedules for Chronic Hepatitis C in the Real Clinical Practice.
Hepatitis C virus (HCV) infection provokes thousands of deaths every year all over the world, being the major cause of progressive liver disease, primary hepatic cancer and liver transplantation.
- Conditions
- Hepatitis C Virus, Chronic Liver Disease, Viral Hepatitis, Therapeutic Uses
- Trial name
- NCT01195181
- Testing
- peginterferon plus ribavirin
- Where
- Italy
- Volunteers
- 506 people
- Sponsor
- Azienda Ospedaliera di Padova
Hepatitis C, Hepatitis C, Chronic
Gradual Withdrawal of Immune System Suppressing Drugs in Patients Receiving a Liver Transplant
In order to prevent organ rejection, patients receiving liver transplants currently require life-long treatment with immune system-suppressing medications to prevent the rejection of the transplanted liver.
- Conditions
- Hepatitis C, Hepatitis C, Chronic, Nonimmune Nonviral Causes of Liver Failure
- Trial name
- A-WISH (NCT00135694)
- Testing
- calcineurin inhibitor-based immunosuppression, liver transplant, corticosteroids
- Where
- 8 sites in United States
- Volunteers
- 275 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Liver Disease
Efficacy and Safety of Sodium Benzoate in the Management of Hyperammonemia in Infants, Children and Adolescent With Chronic Liver Disease.
Subject will be randomize in two groups. Group A will receive drug packets containing 2.5 gm sodium benzoate and 5 gm powdered table sugar for 5days.Since the dosage of Sodium Benzoate is Sta t250mg/Kg and then 250mg/Kg in next…
- Trial name
- NCT04022941
- Testing
- Sodium Benzoate, Powdered table sugar as palcebo
- Where
- India
- Volunteers
- 108 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis
Study Of Bacterial/Fungal Infections in Hospitalized Patients With Liver Cirrhosis in China
This is a national, investigator-initiated, multicenter, prospective, observational, web-based registry in hospitalized patients with cirrhosis across China.
- Trial name
- SONIC (NCT03676777)
- Where
- 23 sites in China
- Volunteers
- 1,232 people
- Sponsor
- Ruijin Hospital
Acute and Chronic Hepatic Failure With Developing Coma
Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development…
- Trial name
- NCT01582087
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute on Chronic Liver Failure
Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is a syndrome associated with a high short- term mortality. Early identification of patients at high risk is important to determine emergency for transplantation and prioritize the need for…
- Trial name
- NCT06069284
- Testing
- No intervention
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Institute of Liver and Biliary Sciences, India