Clinical trials: Chronic Hepatic
Chronic Liver Disease and Cirrhosis
Real-World Validation of a Prognostic Prediction Model for Patients With Acute Exacerbations of Chronic Liver Disease
Our study is a multi-site, prospective, observational study including patients with acute exacerbations of CLD. Approximately 1500 patients from 24 hospitals in diverse regions in China will be enrolled and followed for 3 months.
- Trial name
- NCT06181448
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Dysplastic Nodule of Liver, Chronic Hepatitis B
Prophylactic Treatment of Hepatic Dysplastic Nodules in HBsAg Positive Patients
The aim of this study is to determine that for hepatic dysplastic nodules in patients with chronic hepatitis B, instead of enhanced follow-up, whether early minimally-invasive ablation therapy can reduce the incidence of…
- Trial name
- NCT02793791
- Testing
- minimally invasive ablation therapies
- Volunteers
- 30 people
- Sponsor
- Shandong Cancer Hospital and Institute
Cirrhosis, Acute on Chronic Hepatic Failure
Single Pass Albumin Dialysis in Patients With Cirrhosis
The aim of this study is to determine whether a simplified device of albumin dialysis also has beneficial effects.
- Conditions
- Cirrhosis, Acute on Chronic Hepatic Failure, Hepatorenal Syndrome, Encephalopathy
- Trial name
- DACAR (NCT00764049)
- Testing
- Single pass albumin dialysis
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhotic Cardiomyopathy, Left Ventricular Dysfunction
Ivabradine in Cirrhotic Cardiomyopathy
A total of 130 patients with liver cirrhosis who fulfill the criteria of the study, and who have been found to have left ventricular diastolic dysfunction on a screening 2D echocardiography, will then be randomized by Block…
- Conditions
- Cirrhotic Cardiomyopathy, Left Ventricular Dysfunction, Cirrhosis, Liver, Portal Hypertension
- Trial name
- NCT04111133
- Testing
- Betablocker + ivabradine, Betablocker
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Liver Disease
Delta Radiomics for Liver Function Evaluation
To evaluate the feasibility and efficacy of delta radiomics-derived index based on Gd-EOB-DTPA enhanced MRI as a new imaging biomarker for the quantitative assessment of liver function.
- Trial name
- NCT05296434
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Liver Disease (CLD), Liver Fibrosis
Correlation Of EUS-SWQ And Liver Fibrosis Pathology In Chronic Liver Disease
The goal of this clinical study is to learn whether the Olympus EU-ME3 endoscopic ultrasound shear wave quantification (EUS-SWQ) function can accurately diagnose and grade liver fibrosis in patients with chronic liver disease.
- Trial name
- EUS-SWQ-202601 (NCT07588854)
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Hepatitis C
Evaluating Fine Needle Aspiration to Measure Hepatic Vaniprevir (MK-7009) Concentrations in Participants With Chronic Hepatitis C (MK-7009-048)
This study will evaluate the technical feasibility of using fine needle aspiration (FNA) of liver tissue to obtain vaniprevir (MK-7009) liver pharmacokinetic (PK) data, working towards identifying a minimally invasive…
- Trial name
- NCT01678131
- Testing
- Vaniprevir 600 mg, Peg-IFN alfa-2b, Ribavirin
- Volunteers
- 31 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Liver Disease and Cirrhosis
Immunological Measurement of Aspartate/Alanine Aminotransferase
Previous reports have suggested that ALT-immunoglobulin complex was increased according to the severity of the liver disease, and high concentration of mAST and this might indicate a severely damaged liver.
- Trial name
- NCT03562585
- Testing
- with sandwich ELISA immunoassay with fluorescence labeled monoclonal antibodies
- Volunteers
- 219 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Minimal Hepatic Encephalopathy
Study of Lactulose in Children With Chronic Liver Disease
Pediatric patients with chronic liver disease may have Minimal Hepatic Encephalopathy(MHE)which can cause changes in behavior,intelligence and neurological function.By utilizing cognitive and developmental testing we will…
- Trial name
- MHE (NCT00811434)
- Testing
- Lactulose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Indiana University
Liver Disease Chronic, Hepatitis B Virus
Efficacy of HBVaxpro40© and Fendrix© in Patients With Chronic Liver Disease.
Background: Cirrhotic patients have an increased risk of infections. In these patients is important to prevent hepatitis B virus (HBV) infection, as it may cause a deterioration of liver function.
- Trial name
- NCT03459521
- Testing
- Fendrix or HBVAXPRO 40
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Corporacion Parc Tauli
Acute Liver Failure
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
The artificial liver support system (ALSS) in patients with acute on chronic liver failure - the use of combined molecular adsorption system with double plasma (DPMAS) and therapeutic plasma exchange (TPE), its effect on primary…
- Trial name
- NCT07329036
- Testing
- The artificial liver support system (ALSS) - DPMAS/TPE
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Cancer, Chronic Liver Disease (CLD)
Identification of Patients With Advanced Chronic Diseases in Need of Palliative Care
Patients with advanced chronic diseases often have complex health needs and may benefit from palliative care. However, many of these patients are not identified early enough to receive appropriate palliative care interventions.
- Conditions
- Cancer, Chronic Liver Disease (CLD), Heart Failure Chronic, Chronic Kidney Disease (Stages 4 and 5)
- Trial name
- NECPAL_HUIL (NCT07387224)
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Infanta Leonor University Hospital
Chronic Liver Disease and Cirrhosis
Impact of Liver Transplantation on Sexual Life and Function
Liver Transplantation (LT) is a lifesaving intervention with around 90% of recipients currently surviving the first postoperative year and subsequent life expectancy now exceeding 20 years.
- Trial name
- NCT07268196
- Testing
- No Treatment
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Clostridium Difficile Infection, Multi Drug Resistant Organisms
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with Clostridium Difficile (CDI), subjects affected by Multi Drug Resistant Organisms (MDRO) infection…
- Conditions
- Clostridium Difficile Infection, Multi Drug Resistant Organisms, Chronic Inflammatory Bowel Disease, Irritable Bowel Syndrome
- Trial name
- BIOMIS-Gastr (NCT04698148)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- 3 sites in Italy
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Acute Liver Failure, Acute on Chronic Liver Failure
Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF).
Blood will be collected after venepuncture from all patients for complete blood counts, Serum bilirubin (direct and indirect), aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl…
- Trial name
- NCT01946360
- Testing
- Methacetin Breath Test in ACLF and ALF patients
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Liver Disease, Cirrhosis
MBT Versus HVPG in Identifying Responders to Portal Hypertension Therapy
The purpose of this study is to determine the effect on the (carbon 13 labelled(13C)-Methacetin Breath Test (MBT) of i.v. propranolol, a non-selective beta blocker (NSBB) following initial administration and after chronic use of…
- Conditions
- Chronic Liver Disease, Cirrhosis, Esophageal Varices, Portal Hypertension
- Trial name
- NCT01851252
- Testing
- Methacetin (with Breath testing device)
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Meridian Bioscience, Inc.
Chronic Liver Disease and Cirrhosis
Effectiveness of Nurse-led Physical Therapy in Terms of Patient Competency, Patient Engagement and Physical Performance.
Due to Prolonged diseased Condition, Patients are not able to care for themselves and even avoid movement their range of motion is limited which may develop frailty among Liver disease Patients.
- Trial name
- NCT05376826
- Testing
- Nurse Led Physical Therapy
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Liver Failure
Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction
This study is aimed to assess the efficacy of Human derived Transfer factor ( T-lymphocytes homogenate that contains small molecular weight (10 kDa) molecules: various IFNs, ILs, chemokines, endorfins, heat shock proteins) in…
- Trial name
- IMUNO-HEGITO7 (NCT02837939)
- Testing
- Human derived Transfer factor, Aqua pro injectione 4ml ampules for subcutaneous injection
- Where
- Slovakia
- Sponsor
- Martin Janičko
Chronic Liver Disease and Cirrhosis
Serum Zinc and Serum Magnesium in Chronic Liver Disease Patients
The goal of this observational cross-sectional study is to assess the relationship between serum levels of magnesium and zinc in pediatric and adult patients with chronic liver disease and the clinic-laboratory variables.
- Trial name
- NCT06827769
- Testing
- serum zinc and magnesium
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have Metabolic dysfunction-Associated SteatoHepatitis (MASH).
- Trial name
- NASHGEN-2 (NCT05519475)
- Testing
- ALN-HSD
- Where
- 71 sites in United States, Japan and 2 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals