Clinical trials: Chronic Hepatic
Chronic Liver Disease, Inflammatory Bowel Diseases
Impact of Counselling and Visual Aid on Anxiety in Endoscopic Patients
A single blind randomized controlled trial was conducted to compare the effect of counselling and visual aid on the anxiety levels in patients undergoing endoscopy and to investigate the superiority of visual aid over…
- Trial name
- NCT05241158
- Testing
- Counselling with visual aid, Counselling
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- King Edward Medical University
Chronic Liver Disease
Part A: In Patients With Chronic Liver Diseases, LAENNEC (Human Placenta Hydrolysate) is to Assess Safety and Tolerability After the Doses of Doses. Part B: Part A, it is to Determine the Optimal Dose by Evaluating Two Capacity and Placebo Groups.
Part A: In Patients With Chronic Liver Diseases, LAENNEC (Human Placenta Hydrolysate) is to Assess Safety and Tolerability After the Doses of Doses.
- Trial name
- NCT05532124
- Testing
- LAENNEC (Human Placenta Hydrolysate), normal saline
- Where
- 7 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Green Cross Wellbeing
Thrombocytopenia
Avatrombopag for the Treatment of Thrombocytopenia in Adults With Chronic Liver Disease Undergoing a Procedure
Phase 4 observational cohort study to characterize the treatment patterns and effects of avatrombopag use in patients with thrombocytopenia associated with chronic liver disease who are either undergoing, or have already…
- Trial name
- NCT03554759
- Testing
- Avatrombopag
- Where
- 41 sites in United States
- Volunteers
- 50 people
- Sponsor
- Sobi, Inc.
Acute on Chronic Hepatic Failure
Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
50 patients of Acute-on-chronic liver failure (ACLF) will be enrolled and randomized into G-CSF+EPO or Placebo arms Treatment protocol To administer G-CSF (in prefilled syringe) at a dose of 5 µg/kg s/c at days 1, 2, 3, 4, 5 and…
- Trial name
- NCT01383460
- Testing
- Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO)
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Hepatitis B, Hepatic Fibrosis
Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD
Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C.
- Conditions
- Chronic Hepatitis B, Hepatic Fibrosis, Fatty Liver
- Trial name
- NCT02031913
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Boramae Hospital
Hepatic Steatosis, Hepatic Fibrosis
Effects of Hepatic Fibrosis on Hepatic Steatosis Using the Ultrasound Attenuation Imaging in Chronic Hepatitis B
The investigator aimed to prospectively study the effect of the hepatic fibrosis on quantifying hepatic steatosis using ultrasound attenuation imaging (ATI value) in patients with chronic hepatitis B.
- Conditions
- Hepatic Steatosis, Hepatic Fibrosis, Chronic Hepatitis b
- Trial name
- NCT05871749
- Where
- 2 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- So Yeon Kim
Acute-On-Chronic Liver Failure
TRimetazidine for acUte on Chronic Liver Failure STudy
The study will assess the pharmacokinetics (PK), tolerability, and safety of oral trimetazidine administered to subjects with AD (ACLF Grade 0) or with ACLF Grade 1 or 2.
- Trial name
- TRUST (NCT03737448)
- Testing
- Trimetazidine
- Where
- 24 sites in Austria, Belgium and 3 more
- Volunteers
- 30 people
- Sponsor
- Martin Pharmaceuticals
Liver Cirrhosis, Hepatoencephalopathy, Early Fatal Progressive
Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy
Patients with cirrhosis are particularly prone to infection which is frequently a precipitant of hepatic encephalopathy, renal failure and circulatory collapse.
- Trial name
- RIFSYS (NCT02019784)
- Testing
- Rifaximin-α
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- King's College Hospital NHS Trust
Acute on Chronic Liver Failure (ACLF)
Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF
Clinical trial The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are: Does hemoadsorption plus half-dose plasma exchange provide…
- Trial name
- Phoenix (NCT07593638)
- Testing
- DPMAS plus plasma exchange
- Where
- Portugal
- Volunteers
- 240 people
- Sponsor
- Unidade Local de Saude do Nordeste
Chronic Hepatitis b, Non-alcoholic Fatty Liver Disease
Risk Factors for Hepatic Inflammation, Fibrosis and Prognosis in Patients With CHB and NAFLD
Chronic hepatitis B (CHB) affects an estimated 292 million people, and causes approximately 800,000 people deaths per year from liver-related complications including cirrhosis and hepatocellular carcinoma, remaining a major…
- Trial name
- NCT05766449
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute-on-Chronic Liver Failure, Hepatitis B, Chronic
Prediction Model Based on Computed Tomography Liver Volume for the Short-term Mortality in Hepatitis B Related Acute-on-Chronic
HBV-related acute-on-chronic liver failure (HBV-ACLF) deteriorates rapidly with a high short-term mortality. Early identification and accurate prognostic prediction was critical to improve survival rate.
- Trial name
- NCT03977857
- Where
- China
- Volunteers
- 486 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatitis, Liver Diseases
Evaluation of Orthohepevirus C Infection as an Emerging Cause of Zoonotic Origin Disease
The main objective of this study is to evaluate the prevalence and the clinical impact of Orthohepevirus C infection in different human populations, and to determine its zoonotic origin comparing the sequences obtained in both…
- Conditions
- Hepatitis, Liver Diseases, Acute Hepatitis, Chronic Hepatitis
- Trial name
- NCT05062967
- Where
- 10 sites in Spain
- Volunteers
- 3,257 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Chronic Liver Disease
Albumin Modifications as Early Biomarkers of Chronic Liver Diseases
Chronic liver diseases, affecting over 800 million people worldwide, lead to approximately 2 million annual deaths. The need for early, sensitive diagnostic strategies to prevent disease progression and reduce mortality is still…
- Trial name
- MALAHBAR (NCT06318949)
- Testing
- blood sampling
- Where
- 7 sites in France, Guadeloupe
- Volunteers
- 756 people
- Sponsor
- University Hospital, Limoges
End Stage Renal Disease, End Stage Liver Disease
Transplant Patient Registry of Liver, Kidney and/or Pancreas
This is a registry of data collected from patient records, both of those who have a condition which may require transplantation and those who have undergone transplantation of the liver, kidney and/or pancreas.
- Trial name
- NCT00238693
- Where
- United States
- Volunteers
- 13,767 people
- Sponsor
- Virginia Commonwealth University
Chronic Hepatitis C, Chronic Liver Disease
Long Term Follow-up of Hepatitis C Cured Patients
Objectives: The general objective of the present project is to gain a better understanding of disease outcome in cACLD patients treated with the new oral DAA.
- Conditions
- Chronic Hepatitis C, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT03246048
- Volunteers
- 300 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute-On-Chronic Liver Failure, Hepatic Encephalopathy
Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE
Pretransplant hepatoencephalopathy (HE) markedly impacts recipient outcomes after liver transplantation. Intraoperative CRRT showed benefits but feasibility was much concerned.
- Trial name
- LTeCRRT (NCT04317222)
- Testing
- eCRRT
- Volunteers
- 250 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Purpura, Thrombocytopenic, Idiopathic, Acute Idiopathic Thrombocytopenic Purpura
Subject Variability in Two Lots of E5501 Administered to Fed and Fasted Healthy Subjects
This will be a randomized, open-label, four-group, two-period, replicate design study to evaluate the effect of food on within and between subject variability in second generation formulation 20-mg tablet strengths, Lots…
- Conditions
- Purpura, Thrombocytopenic, Idiopathic, Acute Idiopathic Thrombocytopenic Purpura, Chronic Thrombocytopenia
- Trial name
- NCT01327872
- Testing
- E5501 40 mg 2 x 20-mg tablets, orally, fasted, E5501 40 mg 2 x 20-mg tablets, orally, with food, E5501 40mg 2 x 20-mg tablets, orally, fasted
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Liver Failure, Acute on Chronic
Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure
Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure
- Trial name
- NCT03863002
- Testing
- Mesenchymal Stem Cell
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Tianjin Weikai Bioeng., Ltd.
Steatohepatitis, Nonalcoholic, Steatosis of Liver
Ketogenic Diet in MASLD-related cACLD
The investigators hypothesize that very low ketogenic diet could represent a new therapeutic option in the management of patients with MASLD and cACLD.
- Conditions
- Steatohepatitis, Nonalcoholic, Steatosis of Liver, Cirrhosis, Liver
- Trial name
- NCT06537466
- Testing
- Mediterranean diet, Very Low Ketogenic Diet
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Chronic Liver Disease
Non-invasive Evaluation of Portal Pressure by MRI
The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.
- Trial name
- ENIP (NCT02530567)
- Testing
- Intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse