Clinical trials: Chronic Hepatic
Chronic Liver Disease
Validation of the Second Generation of the Controlled Attenuation Parameter (CAP) Using the MRI-PDFF as Reference
Chronic liver diseases (CLDs) represent a major worldwide public health burden. Worldwide estimations show that 844 million people have CLDs, a lot more than other chronic diseases such as diabetes or cardiovascular diseases.
- Trial name
- NCT03704792
- Testing
- FibroScan 530 Compact
- Where
- 5 sites in France
- Volunteers
- 207 people
- Sponsor
- Echosens
Advanced Chronic Liver Disease
LSM and SSM for the Diagnosis of CSPH: a Prospective Cohort Study
The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease.
- Trial name
- NCT06181409
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hepatitis B, Chronic, Fibrosis, Liver
Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Type 2 Diabetes
An exploratory comparison of changes in liver fibrosis through glycemic control within and between groups after administration of Pioglitazone and Evogliptin in chronic hepatitis B patients with type 2 diabetes and liver fibrosis
- Conditions
- Hepatitis B, Chronic, Fibrosis, Liver, Diabetes Mellitus, Type 2
- Trial name
- NCT05473806
- Testing
- Pioglitazone 15 Mg Oral Tablet, Evogliptin 5mg
- Where
- 4 sites in South Korea
- Volunteers
- 28 people
- Sponsor
- Seung Up Kim
Acute-On-Chronic Liver Failure
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only ~2,500 performed, non-transplant options are urgently needed.
- Trial name
- NC-CHRM (NCT07075315)
- Testing
- Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment
- Where
- 3 sites in India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure, Cirrhosis, Liver
Global Coagulation Assessment in Cirrhosis and ACLF
Background: Patients with cirrhosis and acute-on-chronic liver failure (ACLF) may have bleeding complications which can lead to increased mortality.
- Trial name
- NCT04332484
- Where
- India
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Kidney Injury, Acute-On-Chronic Liver Failure
Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF).
- Trial name
- NCT04525625
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Institutul Clinic Fundeni
Chronic Liver Disease
Colesevelam Versus Placebo in Cholestatic Pruritus
38 patients with pruritus due to chronic cholestatic liver disease will be evaluated in an investigator initiated, multicenter, double-blind, placebo-controlled, 3-week study assessing the effects of colesevelam on pruritus.
- Trial name
- COPE (NCT00756171)
- Testing
- colesevelam
- Where
- 3 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- Foundation for Liver Research
Deep Vein Thrombosis, Chronic Portal Vein Thrombosis
Xarelto Versus no Treatment for the Prevention of Recurrent Thrombosis in Patients With Chronic Portal Vein Thrombosis.
Open randomized therapeutic study to assess the efficacy of Xarelto 15mg/day in the recurrence of thromboembolic event compared to an untreated group in patients with chronic portal vein thrombosis without high risk thrombophilia.
- Trial name
- RIPORT (NCT02555111)
- Testing
- Xarelto
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Chronic Liver Disease
COVID-19 in Patients With Chronic Liver Diseases
This study seeks to determine how COVID-19 affects the clinical outcome of patients with chronic liver disease, and whether the clinical course of COVID-19 is influenced by underlying chronic liver disease.
- Trial name
- COLD (NCT04439084)
- Testing
- Prospective Chart Review
- Where
- 23 sites in United States
- Volunteers
- 1,025 people
- Sponsor
- Stanford University
Chronic Liver Disease
Comparing Portal Vein Assessment by Intraoperative Doppler and Transesophageal Echocardiography
Liver transplantation is usually associated with hemodynamic instability. TEE allows for a real time monitoring of cardiac structures and has become a standard of care for liver transplant patients.
- Trial name
- NCT06909175
- Testing
- Transesophageal echocardiography
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis B Virus, Steatosis
Obeticholic Acid Among Chronic HBV Patients with Hepatic Steatosis : Clinical and Portal Doppler Outcomes
In this study, the investigators aimed to evaluate the hepatoprotective effect of OCA against HBV-induced liver injury by comparing patients demographic , laboratory date ( liver function , viremia ) , degree of hepatic steatosis…
- Trial name
- NCT06691412
- Testing
- Obeticholic Acid 5 mg
- Volunteers
- 100 people
- Sponsor
- Assiut University
Carcinoma, Hepatocellular
Risk Factors and Molecular Genomics of U.S. Patients With Chronic Liver Disease and Hepatocellular Cancer
To identify risk factors for the development and diagnosis of hepatocellular CA in patients with chronic hepatitis C and to use the data to ultimately develop an effective screening program.
- Trial name
- NCT01034865
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Stanford University
Hepatitis B, Chronic, Liver Diseases
A Single-Arm Study Evaluating the Efficacy of Liquid Acupuncture Therapeutics in Chronic Hepatitis B
Study Purpose: The purpose of this study is to assess that Liquid Acupuncture(Herb Acupoints Injection) Therapeutics could achieve permanent efficacy response in Chronic Hepatitis B.
- Conditions
- Hepatitis B, Chronic, Liver Diseases, Virus Diseases, Hepatitis
- Trial name
- CHB (NCT00815464)
- Testing
- Liquid Acupuncture (Herb Acupoint Injection)
- Volunteers
- 30 people
- Sponsor
- Yu Medical Garden
Acute-On-Chronic Liver Failure
Acute-On-Chronic Liver Failure in Zagazig University Hospitals
Rationale: To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals. The question of the research: How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals? The…
- Trial name
- ACLF (NCT03184636)
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Zagazig University
Cirrhosis, Chronic Liver Disease
The Role of Strain Elastography in Staging Liver Fibrosis
AIM: To evaluate the role of Strain Elastography in the assessment of liver fibrosis in chronic hepatopathy
- Trial name
- SELF (NCT02184000)
- Where
- 2 sites in Romania
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy Craiova
Acute Liver Failure
High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure
All the children with acute liver failure who are candidates for transplant but have constraints for transplant will be randomized either to receive standard medical therapy or high volume plasma exchange along with standard…
- Trial name
- NCT02719210
- Testing
- High Volume Plasma Exchange, Hypertonic 3% saline, Mannitol
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Liver Cirrhosis, Liver Fibrosis
Liver and Spleen Stiffness Measured by TE and 2D-SWE for Diagnosis of GOV in Patients With cACLD
A observational diagnostic study will be conducted to compare the performance of liver stiffness and spleen stiffness measured by 2D-shear wave elastography (2D-SWE) and transient elastography (TE) for diagnosing gastroesophageal…
- Conditions
- Liver Cirrhosis, Liver Fibrosis, Portal Hypertension
- Trial name
- NCT06144437
- Testing
- Transient elastography (TE) and 2D-shear wave elastography (2D-SWE)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Liver Disease
Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease
This study plans to learn more about transfusion of a human blood component called plasma in patients who have liver problems. Patients are asked to be in this study because they have liver disease and therefore may require the…
- Trial name
- NCT02366845
- Testing
- Fresh Frozen Plasma, Pre-Transfusion International Normalized Ratio (INR), Post-Transfusion International Normalized Ratio (INR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver