Clinical trials: Chronic Hepatic
Liver Disease Chronic, Fibrosis, Liver
Effectiveness of Ultrasound in Liver Stiffness and Fat Quantification
Liver stiffness is a marker for scarring of the liver, which occurs after damage from various liver conditions. Scarring prevents normal liver function and can lead to liver failure.
- Conditions
- Liver Disease Chronic, Fibrosis, Liver, Liver Steatoses, Liver Fat
- Trial name
- NCT06111859
- Testing
- Ultrasound based Elastography and fat quantification
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust
Acute-On-Chronic Liver Failure, Sepsis
Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis
This study aims to evaluate the efficacy and safety of the double plasma cytokine adsorption system with sequential low-dose plasma exchange (DPCAS+LPE) in patients with acute-on-chronic liver failure (ACLF) complicated by…
- Trial name
- NCT06562803
- Testing
- double plasma cytokine adsorption system with sequential low-dose plasma exchange, plasma exchange
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Non-alcoholic Steatohepatitis, Chronic Liver Disease
Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedures
The purpose of this study is to assess the ability of eltrombopag to elevate platelet counts thereby reducing the need for platelet transfusions in chronic liver disease patients with thrombocytopenia undergoing elective invasive…
- Conditions
- Non-alcoholic Steatohepatitis, Chronic Liver Disease, HCV, NASH - Nonalcoholic Steatohepatitis
- Trial name
- ELEVATE (NCT00678587)
- Testing
- Eltrombopag
- Where
- 107 sites in United States, Argentina and 11 more
- Volunteers
- 292 people
- Sponsor
- GlaxoSmithKline
Hepatitis C, Chronic, Sustained Virological Response
Prediction of Liver-related Outcomes After HCV Cure
Objectives: To develop and validate a predictive model, applicable to daily practice, of liver complications emergence in hepatitis C virus (HCV)-infected patients and advanced fibrosis, who have achieved sustained viral response…
- Conditions
- Hepatitis C, Chronic, Sustained Virological Response, Direct-acting Antivirals, Hepatocellular Carcinoma
- Trial name
- NCT04460157
- Where
- Spain
- Volunteers
- 1,035 people
- Sponsor
- Hospital Universitario de Valme
Acute-On-Chronic Liver Failure
Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy
Coagulation system in cirrhotics patients is a fragile state , which is rebalanced hemostasis. Standard tests (INR/aPTT) stop measuring at first stage of coagulation ,when the clot first form.
- Trial name
- NCT06831565
- Testing
- ROTEM
- Where
- India
- Volunteers
- 790 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure, Alcoholic Hepatitis
CytoSorb® in Patients With Acute on Chronic Liver Failure
The objective of this study is to assess the safety and performance of the CytoSorb® therapy in patients with Acute on Chronic Liver Failure (ACLF) grade ≥ 2 due to a severe alcohol induced hepatitis (Maddrey DF > 32) and a…
- Trial name
- HepOnFire (NCT05131230)
- Testing
- CytoSorb® treatment
- Where
- 2 sites in Germany
- Sponsor
- CytoSorbents Europe GmbH
Liver Cirrhosis, Decompensated Cirrhosis of Liver
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
The goal of this clinical trial is to determine primarily whether a combinatorial therapy based on the administration of human albumin and enoxaparin is safe and effective in patients with decompensated cirrhosis discharged from…
- Conditions
- Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)
- Trial name
- COMBAT (NCT05895136)
- Testing
- Human albumin, Enoxaparin, Standard medical treatment
- Where
- 9 sites in France, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Hypertension, Portal
Spleen-ARFI-assisted-Portal-Hypertension-Evaluation-Study (SAPHES)
This study evaluates correlation in changes of HVPG-pressure values and stiffness values (ARFI) for spleen and liver and flow-volume values in Portal vein in patients with liver cirrhosis/Portal Hypertension, respectively, after…
- Trial name
- SAPHES (NCT03315767)
- Testing
- ARFI-elastography and portal vein flow measurement, HVPG-measurement
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Ulm
Acute-On-Chronic Liver Failure
Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease
The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated…
- Trial name
- NCT03456518
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic
Ultrasound Guided Microwave Ablation of Splenomegaly in Children
Children with liver cirrhosis frequently develops portal hypertension. One of the serious complications to portal hypertension is splenomegaly, which may result in pancytopenia, especially thrombocytopenia that may cause bleeding…
- Conditions
- Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic, Portal Hypertension
- Trial name
- NCT05050994
- Testing
- Microwave ablation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Acute-On-Chronic Liver Failure
Risk Factors Affecting MSC Efficacy in ACLF Patients
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality.
- Trial name
- NCT07198854
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 446 people
- Sponsor
- Sun Yat-sen University
Acute Hepatitis, Chronic Hepatitis
Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency
Evaluate on how well the ELAD system works in treating people with liver failure.
- Trial name
- ELAD (NCT00771446)
- Testing
- ELAD plus standard of care treatment, Standard of care treatment
- Where
- 6 sites in United States
- Volunteers
- 18 people
- Sponsor
- Vital Therapies, Inc.
Chronic Hepatitis B, Chronic Hepatitis C
Assessment of Liver FIBROsis by Real-time Tissue ELASTography in Chronic Liver Disease
This is a multi-center cross-sectional study in which the Real-time Tissue Elastography® measurements will be collected prospectively from patients with chronic hepatitis B or C virus presenting for liver biopsy.
- Trial name
- FIBROELAST (NCT01360879)
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Kindai University
Gastrointestinal Microbiome, Sarcopenia
Characterization of Gut Microbiota in Chronic Liver Disease With Decreased Muscle Mass
The purpose of this study was to confirm the presence of specific gut microbiota observed in patients with sarcopenia among patients who agreed to analyze gut microbiota through stool among multi-center chronic liver disease…
- Conditions
- Gastrointestinal Microbiome, Sarcopenia, Liver Disease Chronic
- Trial name
- NCT05729269
- Testing
- Sarcopenia_CT
- Where
- South Korea
- Volunteers
- 283 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cholestatic Liver Disease, Chronic Liver Disease (CLD)
Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D Deficiency
The goal of this clinical trial is to learn whether adding calcitriol to vitamin D2 can improve vitamin D deficiency in children with cholestasis and chronic liver disease.
- Conditions
- Cholestatic Liver Disease, Chronic Liver Disease (CLD), Vitamin D Deficiency, Children
- Trial name
- VITD-CHOL (NCT07670611)
- Testing
- Vitamin D2, Calcitriol
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Chulalongkorn University
Chronic Liver Disease
Trial to Examine the Effect of Two Doses of GRI-0621 in Patients With Chronic Liver Disease
Primary objectives: To evaluate the change in serum alanine transaminase [ALT] levels from Day 0 to Day 28, following daily doses of 4.5 or 6mg of GRI-0621 compared to placebo, in patients with chronic liver disease and elevated…
- Trial name
- GRI-201 (NCT02949375)
- Testing
- Active Comparator:4.5mg GRI-0621, Active Comparator: 6.0mg GRI-0621
- Where
- South Africa
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GRI Bio Operations, Inc.
Acute Severe Viral Hepatitis, Acute on Chronic Liver Failure
Evaluation of Role of Transient Elastography (Fibroscan) in Differentiating Patients of Acute Severe Viral Hepatitis and Acute on Chronic Liver Failure
Transient elastography is novel non-invasive method for assessment of hepatic fibrosis in patients with chronic liver disease, by measuring liver stiffness.
- Trial name
- ACLF (NCT01866072)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Sir Ganga Ram Hospital
Chronic Pain
Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study
Pain is one of the most common symptoms of extreme stress in youth. Without treatment, short-term pain can last for months to years (called 'chronic pain'; CP), a problem already affecting 1 in 5 Canadian youth.
- Trial name
- NCT05894772
- Testing
- Power over Pain Portal
- Where
- 11 sites in Canada
- Volunteers
- 93 people
- Sponsor
- The Hospital for Sick Children
Attention Deficit Hyperactivity Disorder, Asthma
Using an Online Patient Monitoring System to Improve Care for Children With Chronic Conditions
TriVox Health is an online system designed to make it easy for healthcare providers to monitor patients' disease symptoms and functioning over time and in between in-person visits (http://www.youtube.com/watch?v=VR1vcbx0Ef4).
- Conditions
- Attention Deficit Hyperactivity Disorder, Asthma, Autism Spectrum Disorder, Depression
- Trial name
- TriVoxHealth (NCT02097355)
- Testing
- TriVox for clinical care
- Where
- United States
- Volunteers
- 946 people
- Sponsor
- Boston Children's Hospital