Clinical trials: Chronic Hepatitis B Infections
Hepatitis B, Chronic
Sequential PEG-IFN for HBV After Ending RNA-targeted Regimens
The goal of this clinical trial is to compare sequential PEG-IFNα therapy strategies in chronic hepatitis B (CHB) patients previously treated with ASO/siRNA. The main questions it aims to answer are: 1.
- Trial name
- NCT06923280
- Testing
- Pegylated Interferon-alpha (IFN)
- Where
- 2 sites in China
- Volunteers
- 72 people
- Sponsor
- Huashan Hospital
Hepatitis B
Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody (The SAMBA Study)
Hepatitis B virus (HBV) remains a major global health problem with an estimated 257 million people living with the infection worldwide. Chronic HBV (CHB) is a major cause of liver cirrhosis and hepatocellular carcinoma.
- Trial name
- SAMBA (NCT06668727)
- Testing
- HepB mAb19
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Hepatitis B, Chronic
A Study Evaluating AL-3778 in Combination With Peginterferon Alpha-2a in Chronic Hepatitis B Subjects
This is a Phase 2a, multi-center, randomized, double-blind, placebo-controlled study evaluating the safety, efficacy, and pharmacokinetics (PK) of AL-3778 in combination with Peg-IFN in subjects with Hepatitis B e antigen (HBeAg)…
- Trial name
- NCT03125213
- Testing
- AL-3778, Peginterferon Alfa-2A
- Sponsor
- Alios Biopharma Inc.
Hepatitis B
A Phase IIIb: Long-Term Outcomes for Hepatitis B (HepB) Patients in Some Previous Entecavir (ETV) Trials
The purpose of this study is to follow patients treated in entecavir Phase III and rollover studies for safety experience and Hepatitis B virus (HBV)-related complications.
- Trial name
- NCT01337479
- Volunteers
- 1,097 people
- Sponsor
- Bristol-Myers Squibb
Cancer, Hepatitis B
Widespread vs. Selective Screening for Hepatitis B Infection Prior to Chemotherapy
This trial studies hepatitis B screening strategies of new cancer patients scheduled to undergo chemotherapy. Patients with cancer and hepatitis B virus infection are at risk of reactivation of infection after chemotherapy.
- Conditions
- Cancer, Hepatitis B, HBV, Hepatitis B Infection
- Trial name
- NCT01970254
- Testing
- Hepatitis B Screening, Survey Administration
- Where
- United States
- Volunteers
- 2,206 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Hepatitis B, Steatosis of Liver
Quantitative CT Imaging Parameters for Assessing Hepatic Steatosis in CHB
This study aims to evaluate diagnostic performance of CT attenuation parameters acquired using deep learning algorithm in assessing hepatic steatosis and fibrosis.
- Conditions
- Chronic Hepatitis B, Steatosis of Liver, Fibrosis and Cirrhosis of Liver
- Trial name
- NCT06616103
- Testing
- computerized tomography
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Seoul National University Hospital
Chronic Hepatitis B
Follow Up of Patients Chronic Hepatitis B (CHB) Treated With Sebivo Using the 13C Methacetin Breath Test
Patients with HBeAg negative chronic HBV and evidence of hepatic disease (elevated liver enzymes or evidence of cirrhosis) who have significant viremia are treated with anti HBV therapy.
- Trial name
- NCT01204827
- Testing
- 13C Methacetin Breath Test (BreathID)
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Hepatitis B, HIV
French HIV-HBV Cohort
The overarching purpose of this study is to further understand the reasons for and clinical implications of persistent HBV infection in patients co-infected with HIV and HBV in the era of highly effective antiviral treatment…
- Conditions
- Hepatitis B, HIV, Liver Cirrhosis, End Stage Liver Disease
- Trial name
- COVViB (NCT02889094)
- Testing
- Routine care
- Where
- 4 sites in France
- Volunteers
- 152 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Chronic Hepatitis B
Adefovir Dipivoxil Tablets (10mg) In Chinese Subjects With HBe Antigen Negative Chronic Hepatitis B
This is a phase IV, 2-year, multi-center, single arm and open-label study, evaluating the efficacy and safety with using local manufactured adefovir dipivoxil in Chinese subjects with HBeAg negative chronic hepatitis B
- Trial name
- NCT00324961
- Testing
- adefovir dipivoxil tablets
- Where
- 18 sites in China
- Volunteers
- 533 people
- Sponsor
- GlaxoSmithKline
Hepatitis B, Chronic
Patients With Chronic Hepatitis B and Low Viremia Not Receiving Antiviral Therapy
This observational long-term follow-up study will evaluate demographic, clinical, histological, biochemical, and virological parameters of patients with chronic hepatitis B and low viremia who do not require antiviral therapy…
- Trial name
- NCT01090531
- Where
- 6 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Hepatitis D, Chronic, Hepatitis B Chronic Infection
Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody: a Phase 1b, Open-label Trial in Individuals With Chronic Hepatitis D Infection
Hepatitis D virus (HDV) is a major global health issue, with an estimated 12 million people living with the infection worldwide.
- Trial name
- NCT07610772
- Testing
- HepB mAb19
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 15 people
- Sponsor
- Aarhus University Hospital
Hepatitis B, Chronic Hepatitis B Atypical
Safety, Tolerability, Pharmacokinetics and Antiviral Activity of IONIS-HBVRx in Treatment-Naïve Patients With Chronic HBV Infection
To examine the safety and tolerability of IONIS-HBVRx administration to treatment-naive patients with chronic hepatitis B virus infection
- Trial name
- NCT02981602
- Testing
- IONIS-HBVRx
- Where
- 7 sites in Hong Kong, South Korea
- Volunteers
- 31 people
- Sponsor
- GlaxoSmithKline
Acute-On-Chronic Liver Failure
Platelet Transfusion in HBV-related acute-on Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is a syndrome that has recently been recognized as encompassing acute deterioration of liver function in patients with pre-existing chronic liver disease.
- Trial name
- NCT03713489
- Testing
- platelet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Hepatitis B
Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically Suppressed
The primary objectives of this study are to evaluate the efficacy, safety, and tolerability of switching to tenofovir alafenamide (TAF) versus continuing tenofovir disoproxil fumarate (TDF) in virologically suppressed adults with…
- Trial name
- NCT02979613
- Testing
- TAF, TDF
- Where
- 39 sites in United States, Canada and 6 more
- Volunteers
- 490 people
- Sponsor
- Gilead Sciences
Chronic Hepatitis B
HBsAg Clearance in Inactive Chronic HBsAg Carriers After Interferon Treated
Hepatitis B surface antigen loss/seroconversion, considered to be the ideal outcome of chronic hepatitis B virus (HBV) infection, occurs spontaneously at a low rate in inactive carriers.
- Trial name
- NCT01471535
- Testing
- Pegylated interferon alfa-2a
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Ditan Hospital
Hepatitis B, Chronic
Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection
The purpose of this clinical research study is to learn if the study drug entecavir will prevent the recurrence of hepatitis B virus (HBV) in participants who receive an orthotopic liver transplant (OLT) due to HBV infection.
- Trial name
- NCT00395018
- Testing
- entecavir
- Where
- 32 sites in United States, Argentina and 7 more
- Volunteers
- 109 people
- Sponsor
- Bristol-Myers Squibb
Chronic Hepatitis B
Treatment Prioritisation and Cost-Effectiveness Analysis for HBV Cure - Real-World Evidence from a Territory-Wide Cohort
A number of hepatitis B virus (HBV) cure regimens including antisense oligonucleotide (ASO) and small interfering RNA (siRNA) are under vigorous clinical development and the efficacy and safety will soon be available for…
- Trial name
- NCT06627608
- Volunteers
- 10,000 people
- Sponsor
- Chinese University of Hong Kong
Hepatitis B, Chronic
Influence of Antiviral Treatment to the Long-Term Prognosis of Patients With Chronic HBV Infection
Influence of antiviral treatment to the long term prognosis of patients with chronic HBV infection. The aim of antiviral treatment for HBV is to reduce the long term severe complications.
- Trial name
- NCT00810524
- Testing
- lamivudine, Telbivudine, Enticavir
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Sun Yat-sen University
Hepatitis B, Chronic
Tenofovir Alafenamide With Fine Needle Aspiration Biopsy in Chronic Hepatitis B:
The objective of this study is to identify immunological mechanisms that contribute to normalization of liver inflammation in chronic hepatitis B (CHB) patients starting the antiviral nucleoside analogue, Tenofovir alafenamide…
- Trial name
- NCT04070079
- Testing
- Tenofovir Alafenamide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Chronic Hepatitis B
Telbivudine or Tenofovir Treatment in HBeAg-negative Chronic Hepatitis B Patients Based on the Roadmap Concept
The purpose of this study is to evaluate the efficacy and safety following the Roadmap Concept strategy with an initial monotherapy using either telbivudine or tenofovir in HBeAg negative CHB patients.
- Trial name
- NCT01379508
- Testing
- telbivudine, tenofovir disoproxil fumarate
- Where
- 34 sites in Austria, Bulgaria and 6 more
- Volunteers
- 241 people
- Sponsor
- Novartis Pharmaceuticals