Clinical trials: Chronic Hypercapnic Respiratory Failure
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation.
- Trial name
- NCT01523470
- Testing
- BIPAP Synchrony
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- United Christian Hospital
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Helmet Ventilation in Acute Hypercapnic Respiratory Failure
Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead…
- Trial name
- NCT01645358
- Testing
- Helmet (Starmed), Total Face mask (Respironics)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD, Severe Early-Onset, Ventilatory Failure
Customized Masks in Non-Invasive Mechanical Ventilation
In non-invasive mechanical ventilation (NIMV), the interface is the primary determinant of success, as adherence and quality of therapy mainly depend on it.
- Conditions
- COPD, Severe Early-Onset, Ventilatory Failure, Als, Non Invasive Ventilation
- Trial name
- NCT06215391
- Testing
- 3d printed mask
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario 12 de Octubre
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD)
The investigators hypothesize that continuation of non-invasive ventilation (NIV) at home after an episode of acute hypercapnic respiratory failure (AHRF) treated by NIV in COPD patients would reduce the likelihood of death and…
- Trial name
- NCT00429156
- Testing
- Home non-invasive ventilation
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- United Christian Hospital
COPD
High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent a leading cause of hospital admissions and respiratory intensive care unit (RICU) stays worldwide.
- Trial name
- NCT07381686
- Testing
- Non-Invasive Ventilation (NIV), High-Flow Nasal Cannula (HFNC)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD
Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnic Respiratory Failure, COPD
- Trial name
- NIV-ICU (NCT06888180)
- Testing
- Non interventional study
- Volunteers
- 976 people
- Sponsor
- University Hospital, Caen
Chronic Hypercapnic Respiratory Failure
Monitoring of Patients With Chronic Respiratory Failure Treated With Non-invasive Home Ventilation: Contribution of New Monitoring Tools
Single-center retrospective study conducted on a population of patients with chronic hypercapnic respiratory failure treated by non-invasive ventilation at home, followed at the CHRU of Nancy.
- Trial name
- NCT04872062
- Testing
- NIV cards, Medical file
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure
HFNC and Acute Hypercapnic Respiratory Failure
High-flow nasal cannula (HFNC) enables delivering humidified gas at high-flow rates controlling the oxygen inspired fraction (FiO2). Its efficacy has been demonstrated in hypoxemic acute respiratory failure.
- Conditions
- High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure, COPD Exacerbation
- Trial name
- NCT04109560
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Argentinian Intensive Care Society
Acute on Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome (OHS)
"Post-acute Pickwick Study" (Postacute-Pick-2020)
We propose to carry out a large multicentric, multinational, randomized controlled trial with two phases (two sequential randomized controled trials) to answer two questions: 1) Should hospitalized patients with recently…
- Trial name
- NCT04317326
- Testing
- "Lifestyle modifications" group (Control), Automatic NIV, CPAP treatment group
- Sponsor
- Juan F. Masa
COPD
Sleep Ventilation for Patients With Advanced Hypercapnic COPD
Despite growing evidence showing benefit (in both clinical and cost standpoints), only a small percentage of COPD patients with chronic hypercapnic respiratory failure are managed with nocturnal ventilatory support.
- Trial name
- NCT04210050
- Testing
- Home noninvasive nocturnal ventilation with Breas VIVO 50 home ventilator or newer model as available, Breas Medical., Arterial blood gas (ABG) and serum bicarbonate level, Overnight home oximetry and transcutaneous CO2 monitoring
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center